Abstract Mechanical trauma to the valves of the heart has long been known to be the most reliable experimental method of production of bacterial endocarditis.1 The first attempt by this method is attributed to Rosenbach (1878),2 who in dogs and rabbits succeeded in producing a bacterial endocarditis by injuring the aortic cusps with a nonsterile rod passed through the carotid artery. As the traumatizing agent, Ribbert (1885)3 used suspensions of staphylococci and starch granules from potato cultures; Fulci (1908),4 bacteria in carbon suspension; Panichi and Guelfi (1909),5 bacteria and carcinoma cells; Viti (1912),6 a medium composed of sterile flour and bacteria. Regardless of the nature of the traumatizing agent, a bacterial endocarditis ensued in the injured valves upon implantation of the bacteria. Equally successful was an experiment by Kinsella and Hayes (1927),7 who induced bacterial endocarditis in dogs by injuring the aortic valves with References 1. Blahd, M.; Fran, I., and Saphir, O.: Experimental Endocarditis in Dogs , Arch. Path. 27:424, 1939. 2. Rosenbach, O.: Über artificielle Herzklappenfehler , Arch. exper. Path. u. Pharmakol. 9:1, 1878.Crossref 3. Ribbert, J.: Beiträge zur Localisation der Infectionskrankheiten , Deutsche med. Wchnschr. 11:717, 1885.Crossref 4. Fulci, F.: Experimentelle Versuche über die Existenz einer Endocarditis durch bakterielle Toxine , Beitr. path. Anat. 44:349, 1908. 5. Panichi, L., and Guelfi, C.: Beeinflussung des Endokards durch krebsiges Material , Arch. path. Anat. 198:449, 1909.Crossref 6. Lissauer, M.: Beitrag zur Frage der experimentellen Endocarditis , Zentralbl. allg. Path. 23:243, 1912. 7. Kinsella, R., and Hayes, C.: Further Study of the Bacteremia of Experimental Streptococcus Endocarditis , Proc. Soc. Exper. Biol. & Med. 24:887, 1927. 8. Powers, J. H.: Experimental Production of Mitral Stenosis , Arch. Surg. 18:1945, 1929. 9. Harken, D.: Experiments in Intracardiac Surgery: I. Bacterial Endocarditis , J. Thoracic Surg. 11:656, 1942. 10. Hurst, W. W.; Gleason, A. L., and Schemm, F. R.: Subacute Bacterial Endocarditis After Operation for Tetralogy of Fallot , Northwest Med. 48:763, 1949. 11. Jones, H. E., and Dolton, E. G.: Bacterial Endocarditis After a Taussig-Blalock Operation in a Case of Unusual Pathology , Arch. Dis. Childhood 27:157, 1952. 12. Brunsdon, D. F. V.; Enticknap, J. B., and Milstein, B. B.: Case of Subacute Bacterial Endocarditis Due to Pseudomonas Pyocyanea Complicating Valvotomy for Advanced Mitral Stenosis , Guy's Hosp. Rep. 102:303, 1953. 13. Bondi, A.; Pfaff, F.; Free, E., and Swerlick, R.: Public Health Aspects of the Development of Antibiotic-Resistant Staphylococci , Am. J. Pub. Health 44:789, 1954. 14. Chapman, G. H.; Berens, C.; Nilson, E. L., and Curcio, L. G.: Differentiation of Pathogenic Staphylococci from Nonpathogenic Type , J. Bact. 35:311, 1938. 15. Cobb, C. C.: Bacterial Endocarditis Caused by Coagulase-Negative Staph. Albus , Brit. M. J. 1:90, 1952. 16. Fisher, A. M.; Wagner, H. N., and Ross, R. S.: Staphylococcal Endocarditis , A. M. A. Arch. Int. Med. 95:427, 1955. 17. Finland, M.: Medical Progress: Treatment of Bacterial Endocarditis , New England J. Med. 250:419, 1954. 18. Palmer, H. D., and Kempf, M.: Streptococcus Viridans Bacteremia Following Extraction of Teeth: Case of Multiple Mycotic Aneurysms in Pulmonary Arteries: Report of Cases and Necropsies , J. A. M. A. 113:1788, 1939.
A.M.A. Archives Surgery – American Medical Association
Published: Aug 1, 1956
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