Abstract In patients having primary and secondary syphilis, adequately treated, the Treponema pallidum immobilization (TPI) test and other serologic tests for syphilis (STS) may be reactive or nonreactive.* The test results to some extent depend on the length of time after treatment the blood was drawn, the individual's response to treatment, and the stage of his treatment. It has been observed that the TPI test generally remains reactive for longer periods of time after treatment than the commonly used STS.† This study of patients with treated early symptomatic syphilis was undertaken to compare the reactivity of the TPI test, as modified,5 with the VDRL slide test quantitative. Also, attempts were made to ascertain temporal relationships of results of the TPI test and the VDRL slide test to adequate treatment for the disease in its dark-field positive stages. CLINICAL MATERIAL One hundred eighty-eight patients, who had been References 1. References 1 to 3. 2. References 2 and 4. 3. Supplied by Becton-Dickinson Company, Rutherford, N. J. (tube types S-3204, S-3208.) 4. Nelson, R. A., Jr., and Mayer, M. M.: Immobilization of Treponema Pallidum in Vitro by Antibody Produced in Syphilitic Infection , J. Exper. Med. 89:369-393 ( (April 1) ) 1949.Crossref 5. Magnuson, H. J., and Thompson, F. A., Jr.: Treponemal Immobilization Test of Normal and Syphilitic Serums , J. Ven. Dis. Inform. 30:309-320 ( (Nov.) ) 1949. 6. Miller, J. L.; Slatkin, M. H.; Feiner, R. R.; Portnoy, J., and Cannon, A. B.: Treponemal Immobilization Test: Reliability of Results for the Diagnosis of Syphilis , J. A. M. A. 149:987-991 ( (July 12) ) 1952.Crossref 7. Zellman, H. E., and Nelson, R. A., Jr.: The Effect of Penicillin Therapy on the Titer of Treponemal Immobilizing Antibody in Human Syphilitic Patients, presented before the Symposium on Recent Advances in the Study of Venereal Diseases , Washington, D. C., (April 24) -25, 1951. 8. Portnoy, J.; Harris, A., and Olansky, S.: Studies of the Treponema Pallidum Immobilization (TPI) Test: I. The Effect of Increased Sodium Thioglycollate and Complement , Am. J. Syph. 37: 101-105 ( (March) ) 1953. 9. Manual of Serologic Tests for Syphilis , J. Ven. Dis. Inform. , (Supp. 22) , 1949. 10. Edmundson, W. F.; Ackerman, J. H.; Gutierrez-Salinas, E., and Olansky, S.: Study of the TPI Test in Clinical Syphilis: I. Untreated Early Symptomatic Syphilis , A. M. A. Arch. Dermat. & Syph. 70:298-301 ( (Sept.) ) 1954.
A.M.A. Archives of Dermatology – American Medical Association
Published: Mar 1, 1955