Abstract Immunologic aspects of human cancer have been of intermittent interest for several decades, and the Immunologic approach to the study of malignant disease has been regarded alternately with optimism and skepticism. Recently, autoimmune responses to specific tumor antigens in patients with malignant neoplasms have been investigated by several groups of workers. For example, in 1958 Grace and Kondo reported local inflammatory reactions surrounding tumors in eight patiients.1 Sera from these eight patients gave positive complement fixation reactions with alcoholic extracts of the malignant tissue. Graham and Graham have used the complement fixation test to demonstrate the presence of circulating antibodies in 12 of 48 patients with malignant disease.2 In a later study, they prepared autogenous vaccines from tumors of 232 patients in the hope of increasing resistance to malignant tumors.3 Failure to show local reaction to the vaccine was regarded as an unfavorable clinical sign, apparently indicative References 1. Grace, J.T., Jr., and Kondo, T.: Investigations of Host Resistance in Cancer Patients , Ann Surg 148:633, 1958.Crossref 2. Graham, J.B., and Graham, R.M.: Antibodies Elicited by Cancer in Patients , Cancer 8:409, 1955.Crossref 3. Graham, J.B., and Graham, R.M.: Autogenous Vaccine in Cancer Patients , Surg Gynec Obstet 114: 1, 1962. 4. Wilson, R.H., et al: Clinical and Immunochemical Evidence for Host Resistance to Tumor , abstracted, J Lab Clin Med 58:973, 1961. 5. Hallett, J.W., et al: Autoimmune Complement Fixation Test in Endogenous Uveitis , Arch Ophthal 68:168, 1962.Crossref 6. Aronson, S.B., et al: The Occurrence of an Autoantiuveal Antibody in Human Uveitis , Arch Ophthal 72:621, 1964.Crossref 7. Potts, A.M.: The Reaction of Uveal Pigment in Vitro with Polycyclic Compounds , Invest Ophthal 3: 405, 1964. 8. Ouchterlony, O.: In Vitro Method for Testing the Toxin-Producing Capacity of Diphtheria Bacteria , Acta Path Microbiol Scand 25:186, 1948.Crossref 9. Boyden, S.V.: The Adsorption of Proteins on Erythrocytes Treated With Tannic Acid and Subsequent Hemagglutination by Antiprotein Sera , J Exp Med 93:107, 1951.Crossref 10. Kolmer, J.A.; Spaulding, E.H.; and Robinson, H.W.: Approved Laboratory Technique , ed 5, New York: Appleton-Century-Crofts, 1951. 11. Aronson, S.B.; Schnellmann, D.C.; and Yamamoto, E.A.: Uveal Autoantibody in Ocular Disease, JAMA, to be published.
Archives of Ophthalmology – American Medical Association
Published: Sep 1, 1966
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