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Studies with Live Attenuated Measles-Virus Vaccine: II. Clinical and Immunologic Response of Children in an Open Community

Studies with Live Attenuated Measles-Virus Vaccine: II. Clinical and Immunologic Response of... Abstract Introduction Evaluation of a live attenuated measles-virus vaccine propagated in canine renal cell culture revealed this antigen to be highly immunogenic in man when administered by various routes.1 However, reactions to this and other attenuated measles vaccines2-4 were not invariably mild when the virus was administered by a parenteral route. Aerosolization and intranasal instillation of dog kidney measles vaccine resulted in a more benign vaccine-induced infection. Therefore, we were encouraged to pursue the evaluation of these methods of immunization. In addition, the theoretical possibility of controlling reactions to vaccine with gamma globulin without jeopardizing immunogenicity was sufficiently attractive to justify investigation of this procedure. Accordingly, normal children in an open community were immunized with attenuated measles vaccine by these methods. Results of the first of a series of studies conducted in the public and parochial schools of St. Joseph, Mo. between December, 1959, and November, 1960, are presented References 1. McCrumb, F. R., Jr.; Kress, S.; Saunders, E.; Snyder, M. J., and Schluederberg, A. E.: Studies with Live Attenuated Measles-Virus Vaccine: I. Clinical and Immunologic Responses in Institutionalized Children, this issue, p. 689. 2. Katz, S. L.; Kempe, C. H.; Black, F. L.; Lepow, M. L.; Krugman, S.; Haggerty, R. J., and Enders, J. F.: Studies on an Attenuated Measles-Virus Vaccine: VIII. General Summary and Evaluation of the Results of Vaccination , New Engl. J. Med. 263:27-31 ( (July 28) ) 1960. 3. Hoekenga, M. T.; Schwarz, A. J. F.; Palma, H. C., and Boyer, P. A.: Experimental Vaccination Against Measles: II. Tests of Live Measles and Live Distemper Vaccine in Human Volunteers During a Measles Epidemic in Panama , J.A.M.A. 173:868-872 ( (June 25) ) 1960.Crossref 4. Smorodintsev, A. A.; Boichuk, L. M.; Shikina, E. S.; Batanova, T. B.; Bystryakova, L. V., and Peradze, T. V.: Clinical and Immunological Response to Live Tissue Culture Vaccine Against Measles , Acta Virol. 4:201-214 ( (July) ) 1960. 5. Musser, S. J., and Slater, E. A.: Studies with Live Attenuated Measles-Virus Vaccine: Preparation of Vaccine and Preliminary Studies in Human Beings, to be published. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Studies with Live Attenuated Measles-Virus Vaccine: II. Clinical and Immunologic Response of Children in an Open Community

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References (4)

Publisher
American Medical Association
Copyright
Copyright © 1961 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1961.04020070015004
Publisher site
See Article on Publisher Site

Abstract

Abstract Introduction Evaluation of a live attenuated measles-virus vaccine propagated in canine renal cell culture revealed this antigen to be highly immunogenic in man when administered by various routes.1 However, reactions to this and other attenuated measles vaccines2-4 were not invariably mild when the virus was administered by a parenteral route. Aerosolization and intranasal instillation of dog kidney measles vaccine resulted in a more benign vaccine-induced infection. Therefore, we were encouraged to pursue the evaluation of these methods of immunization. In addition, the theoretical possibility of controlling reactions to vaccine with gamma globulin without jeopardizing immunogenicity was sufficiently attractive to justify investigation of this procedure. Accordingly, normal children in an open community were immunized with attenuated measles vaccine by these methods. Results of the first of a series of studies conducted in the public and parochial schools of St. Joseph, Mo. between December, 1959, and November, 1960, are presented References 1. McCrumb, F. R., Jr.; Kress, S.; Saunders, E.; Snyder, M. J., and Schluederberg, A. E.: Studies with Live Attenuated Measles-Virus Vaccine: I. Clinical and Immunologic Responses in Institutionalized Children, this issue, p. 689. 2. Katz, S. L.; Kempe, C. H.; Black, F. L.; Lepow, M. L.; Krugman, S.; Haggerty, R. J., and Enders, J. F.: Studies on an Attenuated Measles-Virus Vaccine: VIII. General Summary and Evaluation of the Results of Vaccination , New Engl. J. Med. 263:27-31 ( (July 28) ) 1960. 3. Hoekenga, M. T.; Schwarz, A. J. F.; Palma, H. C., and Boyer, P. A.: Experimental Vaccination Against Measles: II. Tests of Live Measles and Live Distemper Vaccine in Human Volunteers During a Measles Epidemic in Panama , J.A.M.A. 173:868-872 ( (June 25) ) 1960.Crossref 4. Smorodintsev, A. A.; Boichuk, L. M.; Shikina, E. S.; Batanova, T. B.; Bystryakova, L. V., and Peradze, T. V.: Clinical and Immunological Response to Live Tissue Culture Vaccine Against Measles , Acta Virol. 4:201-214 ( (July) ) 1960. 5. Musser, S. J., and Slater, E. A.: Studies with Live Attenuated Measles-Virus Vaccine: Preparation of Vaccine and Preliminary Studies in Human Beings, to be published.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Jun 1, 1961

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