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Studies on the Metabolism of the Regenerating Rabbit Lens

Studies on the Metabolism of the Regenerating Rabbit Lens Abstract According to Chanturishvili,1 the possibility of lenticular regeneration was first suggested over 100 years ago. However, it was not until 1956 that Sicharulidze2 reported on the apparently successful regeneration of lens fibers in the rabbit. He employed epidermis from the upper and lower lid commissures of the rabbit embryo and transplanted this tissue into the anterior chamber of the rabbit eye after an extracapsular lens extraction had been performed. Chanturishvili1 essentially corroborated these results with mouse experiments in 1958. In 1959, Stewart and 'Espinase3 also reported that the implantation of the fetal tissue resulted in apparently full regeneration of the rabbit lens approximately ten months after surgery. In all of these studies cytolyzing fetal ectoderm was employed and no significant lens regeneration was observed without this tissue. Recent reports4,5 would indicate that in the rabbit eye a similar degree of lens regeneration can be obtained References 1. Chanturishvili, P.S.: The Role of Ectoderm in Development of the Crystalline Lens , Trans Ophthal Soc UK 78:411, 1958. 2. Sicharulidze, T.A.: Substitution of Embryonal Skin Ectoderm for the Lens of a Rabbit , Bull Acad Sci Georg SSR 14:337, 1956. 3. Stewart, D.S., and 'Espinase, P.G.: Regeneration of the Lens of the Eye in the Rabbit , Nature 183:1815, 1959.Crossref 4. Binder, H.F., et al: Influence of Embryonic Implants Upon Lens Regeneration in Rabbits , Brit J Ophthal 46:416, 1962.Crossref 5. Pettit, T.H.: A Study of Lens Regeneration in the Rabbit , Invest Ophthal 2:243, 1963. 6. Lerman, S.; Devi, A.; and Banerjee, R.: Effect of Ionizing Radiation on Protein and Carbohydrate Metabolism in the Rat Lens , Invest Ophthal 1:95, 1962. 7. Schneider, W.C.: Phosphorous Compounds in Animal Tissues. I. Extraction and Estimation of Desoxypentose Nucleic Acid and of Pentose Nucleic Acid , J Biol Chem 161:293, 1945. 8. Mejbaum, W.: Ueber die Bestimmung Kleiner Pentosemengen Insbesondere in Derivation der Adenylsaure , Z Physiol Chem 258:117, 1939.Crossref 9. Lowry, O.H., et al: Protein Measurement With Folin Phenol Reagent , J Biol Chem 193:256, 1951. 10. Zigman, S., et al: Nucleic Acid Metabolism in the Lens. II. Ribonuclease Activity and RNA Turnover Invest Ophthal 2:621, 1963. 11. Lerman, S., and Zigman, S.: Nucleic Acid Metabolism in the Lens. III . Invest Ophthal 2:626, 1963. 12. Strehler, B.L., and Totter, J.R.: Firefly Luminescence in the Study of Energy Transfer Mechanisms. I. Substrate and Enzyme Determination , Arch Biochem 40:28, 1952.Crossref 13. Allen, E.H., and Schweet, R.S.: Synthesis of Hemoglobin in a Cell-Free System. I. Properties of Complete System , J Biol Chem 237:760, 1962. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Studies on the Metabolism of the Regenerating Rabbit Lens

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Publisher
American Medical Association
Copyright
Copyright © 1965 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1965.00970040246023
Publisher site
See Article on Publisher Site

Abstract

Abstract According to Chanturishvili,1 the possibility of lenticular regeneration was first suggested over 100 years ago. However, it was not until 1956 that Sicharulidze2 reported on the apparently successful regeneration of lens fibers in the rabbit. He employed epidermis from the upper and lower lid commissures of the rabbit embryo and transplanted this tissue into the anterior chamber of the rabbit eye after an extracapsular lens extraction had been performed. Chanturishvili1 essentially corroborated these results with mouse experiments in 1958. In 1959, Stewart and 'Espinase3 also reported that the implantation of the fetal tissue resulted in apparently full regeneration of the rabbit lens approximately ten months after surgery. In all of these studies cytolyzing fetal ectoderm was employed and no significant lens regeneration was observed without this tissue. Recent reports4,5 would indicate that in the rabbit eye a similar degree of lens regeneration can be obtained References 1. Chanturishvili, P.S.: The Role of Ectoderm in Development of the Crystalline Lens , Trans Ophthal Soc UK 78:411, 1958. 2. Sicharulidze, T.A.: Substitution of Embryonal Skin Ectoderm for the Lens of a Rabbit , Bull Acad Sci Georg SSR 14:337, 1956. 3. Stewart, D.S., and 'Espinase, P.G.: Regeneration of the Lens of the Eye in the Rabbit , Nature 183:1815, 1959.Crossref 4. Binder, H.F., et al: Influence of Embryonic Implants Upon Lens Regeneration in Rabbits , Brit J Ophthal 46:416, 1962.Crossref 5. Pettit, T.H.: A Study of Lens Regeneration in the Rabbit , Invest Ophthal 2:243, 1963. 6. Lerman, S.; Devi, A.; and Banerjee, R.: Effect of Ionizing Radiation on Protein and Carbohydrate Metabolism in the Rat Lens , Invest Ophthal 1:95, 1962. 7. Schneider, W.C.: Phosphorous Compounds in Animal Tissues. I. Extraction and Estimation of Desoxypentose Nucleic Acid and of Pentose Nucleic Acid , J Biol Chem 161:293, 1945. 8. Mejbaum, W.: Ueber die Bestimmung Kleiner Pentosemengen Insbesondere in Derivation der Adenylsaure , Z Physiol Chem 258:117, 1939.Crossref 9. Lowry, O.H., et al: Protein Measurement With Folin Phenol Reagent , J Biol Chem 193:256, 1951. 10. Zigman, S., et al: Nucleic Acid Metabolism in the Lens. II. Ribonuclease Activity and RNA Turnover Invest Ophthal 2:621, 1963. 11. Lerman, S., and Zigman, S.: Nucleic Acid Metabolism in the Lens. III . Invest Ophthal 2:626, 1963. 12. Strehler, B.L., and Totter, J.R.: Firefly Luminescence in the Study of Energy Transfer Mechanisms. I. Substrate and Enzyme Determination , Arch Biochem 40:28, 1952.Crossref 13. Allen, E.H., and Schweet, R.S.: Synthesis of Hemoglobin in a Cell-Free System. I. Properties of Complete System , J Biol Chem 237:760, 1962.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Aug 1, 1965

References

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