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STUDIES ON THE INTRAOCULAR PENETRATION AND TOXICITY OF TERRAMYCIN

STUDIES ON THE INTRAOCULAR PENETRATION AND TOXICITY OF TERRAMYCIN Abstract TERRAMYCIN, an antibiotic with a broad antibacterial spectrum, is an elaboration product of the actinomycete Streptomyces rimosus.1 Investigators2 have reported on the effectiveness of terramycin in the treatment of bacterial, viral, rickettsial, and protozoan diseases. Welch and associates3 have reported on the absorption, distribution, and excretion of this antibiotic after systemic administration to man and the experimental animal. The toxic properties have been investigated by Schoenbach, Bryer, and Long.4 The present study was undertaken to evaluate the penetrability of terramycin into the ocular fluids and tissues after local and systemic administration. Additional experiments were devised to study the toxic effects of terramycin on ocular tissues. Since this study was undertaken, reports on the intraocular penetration of terramycin and its clinical effectiveness have appeared.5 GENERAL PROCEDURE Local Administration. —Solutions: Drops of terramycin hydrochloride in aqueous solution in concentrations of 5 and 25 mg. per cubic centimeter References 1. Finlay, A. C., and others: Terramycin, A New Antibiotic , Science 111:85, 1950.Crossref 2. Finland, M.; Gocke, T. M.; Jackson, G. G.; Womack, C. R., and Kass, E. H.: Clinical Studies on Terramycin , Ann. New York Acad. Sc. 53:290, 1950.Crossref 3. Hobby, G. L.; Dougherty, N.; Lenert, T. F.; Hudders, E., and Kiseluk, M.: Antimicrobial Action of Terramycin in Vitro and in Vivo , Proc. Soc. Exper. Biol. & Med. 73:503, 1950. 4. Welch, H.; Hendricks, F. D.; Price, C. W., and Randall, W. A.: Comparative Studies on Terramycin and Aureomycin: Antibacterial Spectrum, Serum Concentrations and Urinary Excretion , J. Am. Pharm. A. 39:185, 1950. 5. Schoenbach, E. B.; Bryer, M. S., and Long, P. H.: Pharmacology of Terramycin in Animals and Man with Reference to Its Clinical Trial , Ann. New York Acad. Sc. 53:245, 1950. 6. Douvas, N. G.; Featherstone, R. M., and Braley, A. E.: Role of Terramycin in Ophthalmology , A. M. A. Arch. Ophth. 46:57 ( (July) ) 1951. 7. Town, A. E.: Ophthalmic Use of Terramycin , Am. J. Ophth. 34:723, 1951. 8. Thygeson, P.: Terramycin in Ocular Infections, presented at the 87th Annual Meeting of the American Ophthalmological Society, White Sulphur Springs, W. Va., June 7-9, 1951. 9. Mitsui, Y., and others: Terramycin in the Treatment of Trachoma , A. M. A. Arch. Ophth. 46:235 ( (Sept.) ) 1951. 10. "Veterinary nembutal® sodium" contains per cubic centimeter 60 mg. of pentobarbital sodium, 10% alcohol, and 20% propylene glycol in water. 11. Marr, W. G.; Wood, R., and Storck, M.: Regeneration of Corneal Epithelium , Am. J. Ophth. 34:609, 1951. 12. Leopold, I. H., and LaMotte, W. O., Jr.: Penetration of Penicillin in Rabbit Eyes with Normal, Inflamed and Abraded Corneas , Arch. Ophth. 33:43 ( (Jan.) ) 1945. 13. Leopold, I. H., and Nichols, A.: Intraocular Penetration of Streptomycin Following Systemic and Local Administration , Arch. Ophth. 35:33 ( (Jan.) ) 1946. 14. Bellows, J. G., and Farmer, C. J.: Use of Bacitracin in Ocular Infections: Tolerance and Permeability in Rabbit Eye , Am. J. Ophth. 31:1070, 1948. 15. Bellows, J. G.; Richardson, V. M., and Farmer, C. J.: Aureomycin in Ophthalmology , Am. J. Ophth. 33:273, 1950. 16. Leopold, I. H.; Nichols, A., and Vogel, A. W.: Penetration of Chloramphenicol into the Eye , Arch. Ophth. 44:22 ( (July) ) 1950. 17. Vogel, A. W.; Nichols, A., and Leopold, I. H.: Ocular Tolerance and Penetration of Locally Applied Neomycin , Am. J. Ophth. 34:1357, 1951. 18. Leopold and LaMotte.7 Leopold and Nichols.8 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Ophthalmology American Medical Association

STUDIES ON THE INTRAOCULAR PENETRATION AND TOXICITY OF TERRAMYCIN

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Publisher
American Medical Association
Copyright
Copyright © 1952 American Medical Association. All Rights Reserved.
ISSN
0096-6339
DOI
10.1001/archopht.1952.01700030352008
Publisher site
See Article on Publisher Site

Abstract

Abstract TERRAMYCIN, an antibiotic with a broad antibacterial spectrum, is an elaboration product of the actinomycete Streptomyces rimosus.1 Investigators2 have reported on the effectiveness of terramycin in the treatment of bacterial, viral, rickettsial, and protozoan diseases. Welch and associates3 have reported on the absorption, distribution, and excretion of this antibiotic after systemic administration to man and the experimental animal. The toxic properties have been investigated by Schoenbach, Bryer, and Long.4 The present study was undertaken to evaluate the penetrability of terramycin into the ocular fluids and tissues after local and systemic administration. Additional experiments were devised to study the toxic effects of terramycin on ocular tissues. Since this study was undertaken, reports on the intraocular penetration of terramycin and its clinical effectiveness have appeared.5 GENERAL PROCEDURE Local Administration. —Solutions: Drops of terramycin hydrochloride in aqueous solution in concentrations of 5 and 25 mg. per cubic centimeter References 1. Finlay, A. C., and others: Terramycin, A New Antibiotic , Science 111:85, 1950.Crossref 2. Finland, M.; Gocke, T. M.; Jackson, G. G.; Womack, C. R., and Kass, E. H.: Clinical Studies on Terramycin , Ann. New York Acad. Sc. 53:290, 1950.Crossref 3. Hobby, G. L.; Dougherty, N.; Lenert, T. F.; Hudders, E., and Kiseluk, M.: Antimicrobial Action of Terramycin in Vitro and in Vivo , Proc. Soc. Exper. Biol. & Med. 73:503, 1950. 4. Welch, H.; Hendricks, F. D.; Price, C. W., and Randall, W. A.: Comparative Studies on Terramycin and Aureomycin: Antibacterial Spectrum, Serum Concentrations and Urinary Excretion , J. Am. Pharm. A. 39:185, 1950. 5. Schoenbach, E. B.; Bryer, M. S., and Long, P. H.: Pharmacology of Terramycin in Animals and Man with Reference to Its Clinical Trial , Ann. New York Acad. Sc. 53:245, 1950. 6. Douvas, N. G.; Featherstone, R. M., and Braley, A. E.: Role of Terramycin in Ophthalmology , A. M. A. Arch. Ophth. 46:57 ( (July) ) 1951. 7. Town, A. E.: Ophthalmic Use of Terramycin , Am. J. Ophth. 34:723, 1951. 8. Thygeson, P.: Terramycin in Ocular Infections, presented at the 87th Annual Meeting of the American Ophthalmological Society, White Sulphur Springs, W. Va., June 7-9, 1951. 9. Mitsui, Y., and others: Terramycin in the Treatment of Trachoma , A. M. A. Arch. Ophth. 46:235 ( (Sept.) ) 1951. 10. "Veterinary nembutal® sodium" contains per cubic centimeter 60 mg. of pentobarbital sodium, 10% alcohol, and 20% propylene glycol in water. 11. Marr, W. G.; Wood, R., and Storck, M.: Regeneration of Corneal Epithelium , Am. J. Ophth. 34:609, 1951. 12. Leopold, I. H., and LaMotte, W. O., Jr.: Penetration of Penicillin in Rabbit Eyes with Normal, Inflamed and Abraded Corneas , Arch. Ophth. 33:43 ( (Jan.) ) 1945. 13. Leopold, I. H., and Nichols, A.: Intraocular Penetration of Streptomycin Following Systemic and Local Administration , Arch. Ophth. 35:33 ( (Jan.) ) 1946. 14. Bellows, J. G., and Farmer, C. J.: Use of Bacitracin in Ocular Infections: Tolerance and Permeability in Rabbit Eye , Am. J. Ophth. 31:1070, 1948. 15. Bellows, J. G.; Richardson, V. M., and Farmer, C. J.: Aureomycin in Ophthalmology , Am. J. Ophth. 33:273, 1950. 16. Leopold, I. H.; Nichols, A., and Vogel, A. W.: Penetration of Chloramphenicol into the Eye , Arch. Ophth. 44:22 ( (July) ) 1950. 17. Vogel, A. W.; Nichols, A., and Leopold, I. H.: Ocular Tolerance and Penetration of Locally Applied Neomycin , Am. J. Ophth. 34:1357, 1951. 18. Leopold and LaMotte.7 Leopold and Nichols.8

Journal

A.M.A. Archives of OphthalmologyAmerican Medical Association

Published: Mar 1, 1952

References

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