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STUDIES ON SENSITIVITY TO SULFONAMIDE OINTMENTS

STUDIES ON SENSITIVITY TO SULFONAMIDE OINTMENTS Abstract MANY reports in the literature emphasize the frequent occurrence of cutaneous sensitivity following the topical application of the sulfonamide group of drugs. Darke1 treated 218 patients with injuries of a minor surgical nature with a 5 per cent sulfathiazole cream and observed 12 instances in which sensitivity developed (5.5 per cent). Inges2 treated 300 patients with sulfathiazole and sulfadiazine in salves, powders and lotions. Sensitivity reactions were observed in 10 patients (3.3 per cent). Robert3 observed 4 cases of hypersensitivity to sulfathiazole ointment when making patch tests on 200 patients who had never been treated with sulfathiazole. Cole,4 in the report for the Council on Pharmacy and Chemistry of the American Medical Association, reviewed the literature on the local use of the sulfonamide compounds in dermatology. He advised that sulfonamide drugs should not be applied locally for more than five days because of the danger of References 1. Darke, R. A.: Sensitivity to Topical Application of Sulfathiazole Ointment , J. A. M. A. 124:403-404 ( (Feb. 12) ) 1944.Crossref 2. Inges, A. E.: Dermatoses: Local Treatment with Sulfathiazole and Sulfadiazine , California & West. Med. 58:269-272 ( (May) ) 1943. 3. Robert, P.: Uses of Sulfonamides in Dermatology , Schweiz. med. Wchnschr. 73:627-632 ( (May 8) ) 1943. 4. Cole, H. N.: Chemotherapy in Dermatology , J. A. M. A. 123:411-417 ( (Oct. 16) ) 1943. 5. Information supplied to us indicated that at a pH of 7 to 7.5 only minute amounts of the sodium salts of sulfathiazole or sulfadiazine would be available. 6. Schwartz, L., and Peck, S. M.: The Patch Test in Contact Dermatitis , Pub. Health Rep. 59:546-557 ( (April 28) ) 1944. 7. One plus was a reaction of erythema, 2 plus erythema and edema, 3 plus erythema, papules and a few vesicles and 4 plus erythema, edema, many vesicles and, in some cases, ulceration. 8. Darke.1 Inges.2 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

STUDIES ON SENSITIVITY TO SULFONAMIDE OINTMENTS

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Publisher
American Medical Association
Copyright
Copyright © 1947 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1947.01520120063006
Publisher site
See Article on Publisher Site

Abstract

Abstract MANY reports in the literature emphasize the frequent occurrence of cutaneous sensitivity following the topical application of the sulfonamide group of drugs. Darke1 treated 218 patients with injuries of a minor surgical nature with a 5 per cent sulfathiazole cream and observed 12 instances in which sensitivity developed (5.5 per cent). Inges2 treated 300 patients with sulfathiazole and sulfadiazine in salves, powders and lotions. Sensitivity reactions were observed in 10 patients (3.3 per cent). Robert3 observed 4 cases of hypersensitivity to sulfathiazole ointment when making patch tests on 200 patients who had never been treated with sulfathiazole. Cole,4 in the report for the Council on Pharmacy and Chemistry of the American Medical Association, reviewed the literature on the local use of the sulfonamide compounds in dermatology. He advised that sulfonamide drugs should not be applied locally for more than five days because of the danger of References 1. Darke, R. A.: Sensitivity to Topical Application of Sulfathiazole Ointment , J. A. M. A. 124:403-404 ( (Feb. 12) ) 1944.Crossref 2. Inges, A. E.: Dermatoses: Local Treatment with Sulfathiazole and Sulfadiazine , California & West. Med. 58:269-272 ( (May) ) 1943. 3. Robert, P.: Uses of Sulfonamides in Dermatology , Schweiz. med. Wchnschr. 73:627-632 ( (May 8) ) 1943. 4. Cole, H. N.: Chemotherapy in Dermatology , J. A. M. A. 123:411-417 ( (Oct. 16) ) 1943. 5. Information supplied to us indicated that at a pH of 7 to 7.5 only minute amounts of the sodium salts of sulfathiazole or sulfadiazine would be available. 6. Schwartz, L., and Peck, S. M.: The Patch Test in Contact Dermatitis , Pub. Health Rep. 59:546-557 ( (April 28) ) 1944. 7. One plus was a reaction of erythema, 2 plus erythema and edema, 3 plus erythema, papules and a few vesicles and 4 plus erythema, edema, many vesicles and, in some cases, ulceration. 8. Darke.1 Inges.2

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Dec 1, 1947

References