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Studies of the Bone Marrow in Immunological Granulocytopenia: Following Administration of Salicylazosulfapyridine

Studies of the Bone Marrow in Immunological Granulocytopenia: Following Administration of... Abstract Severe granulocytopenia associated with a decreased resistance to infections was recognized as a new disease syndrome in 1922.1 Nine years later Kracke directed attention to the causal relationship of drugs.2,3 Shortly thereafter, Madison and Squier4 collected evidence that, of all drugs then in use, aminopyrine was most clearly implicated. These authors were also the first to reproduce granulocytopenia by the administration of aminopyrine to patients who had recovered from previous episodes associated with the use of an aminopyrine barbiturate preparation. A dose of 0.3 gm. by mouth was followed within hours by fever, malaise, and a precipitous fall in granulocytes in one patient. The second exhibited only a sharp drop in granulocyte count following the medication. These clinical experiments were repeated and confirmed by others.5,6 Plum's 7 studies of the bone marrow during the administration of aminopyrine to three sensitive patients are of particular interest. He noted a decrease in References 1. Schultz, W.: Über eigenartige Halserkrankungen , Deutsche med. Wchnschr. 48:1495, 1922. 2. Kracke, R. R.: Recurrent Agranulocytosis: Report of an Unusual Case , Am. J. Clin. Path. 1:385, 1931. 3. Kracke, R. R.: The Experimental Production of Agranulocytosis , Am. J. Clin. Path. 2:11, 1932. 4. Madison, F. W., and Squier, T. L.: The Etiology of Primary Granulocytopenia (Agranulocytic Angina) , J. A. M. A. 102:755, 1934.Crossref 5. Benjamin, J. E., and Biederman, J. B.: Agranulocytic Leukopenia: Report of Case Successfully Treated with X-Rays and Some Observations on Effect of Amidopyrine , J. A. M. A. 103: 161, 1934.Crossref 6. Dameshek, W., and Colmes, A.: The Effects of Drugs in the Production of Agranulocytosis with Particular Reference to Amidopyrine Hypersensitivity , J. Clin. Invest. 15:85, 1936.Crossref 7. Plum, P.: Clinical and Experimental Investigations in Agranulocytosis , London, H. K. Lewis & Co., Ltd., 1937. 8. Dameshek, W.: Agranulocytosis, in Oxford Loose-Leaf Medicine , edited by H. A. Christian, New York, Oxford University Press, 1944, Vol. 2, Pt. 2. 9. Long, P. H.; Haviland, J. W.; Edwards, L. B., and Bliss, E. A.: The Toxic Manifestations of Sulfanilamide and Its Derivatives, with Reference to Their Importance in Course of Therapy , J. A. M. A. 115:364, 1940.Crossref 10. Moeschlin, S., and Wagner, K.: Agranulocytosis Due to the Occurrence of Leukocyte-Agglutinins (Pyramidon and Cold Agglutinins) , Acta haemat. 8:29, 1952.Crossref 11. Moeschlin, S.: Immunological Granulocytopenia and Agranulocytosis (Clinical Aspects) , Sang 26:32, 1955. 12. Svartz, N.: Salazopyrin, a New Sulfanilamide Preparation , Acta med. scandinav. 110:577, 1942.Crossref 13. Levy, C. W. D.: Agranulocytose ved salazopyrinbruk: Meddeldse om et tilfelle , Tidsskr. norske lægefor. 69:255, 1949. 14. Dausset, J.; Nenna, A., and Brecy, H.: Leukoagglutinins: V. Leukoagglutinins in Chronic Idiopathic or Symptomatic Pancytopenia and in Paroxysmal Nocturnal Hemoglobinuria , Blood 9:696, 1954. 15. Craddock, C. G., Jr.; Perry, S., and Lawrence, J. L.: The Dynamics of Leukopoiesis and Leukocytosis as Studied by Leukophoresis and Isotopic Techniques , J. Clin. Invest. 35:285, 1956.Crossref 16. Koszewski, B. J., and Hubbard, T. F.: Immunologic Agranulocytosis Due to Mercurial Diuretics , Am. J. Med. 20:958, 1956.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Internal Medicine American Medical Association

Studies of the Bone Marrow in Immunological Granulocytopenia: Following Administration of Salicylazosulfapyridine

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Publisher
American Medical Association
Copyright
Copyright © 1958 American Medical Association. All Rights Reserved.
ISSN
0888-2479
DOI
10.1001/archinte.1958.00260140076012
Publisher site
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Abstract

Abstract Severe granulocytopenia associated with a decreased resistance to infections was recognized as a new disease syndrome in 1922.1 Nine years later Kracke directed attention to the causal relationship of drugs.2,3 Shortly thereafter, Madison and Squier4 collected evidence that, of all drugs then in use, aminopyrine was most clearly implicated. These authors were also the first to reproduce granulocytopenia by the administration of aminopyrine to patients who had recovered from previous episodes associated with the use of an aminopyrine barbiturate preparation. A dose of 0.3 gm. by mouth was followed within hours by fever, malaise, and a precipitous fall in granulocytes in one patient. The second exhibited only a sharp drop in granulocyte count following the medication. These clinical experiments were repeated and confirmed by others.5,6 Plum's 7 studies of the bone marrow during the administration of aminopyrine to three sensitive patients are of particular interest. He noted a decrease in References 1. Schultz, W.: Über eigenartige Halserkrankungen , Deutsche med. Wchnschr. 48:1495, 1922. 2. Kracke, R. R.: Recurrent Agranulocytosis: Report of an Unusual Case , Am. J. Clin. Path. 1:385, 1931. 3. Kracke, R. R.: The Experimental Production of Agranulocytosis , Am. J. Clin. Path. 2:11, 1932. 4. Madison, F. W., and Squier, T. L.: The Etiology of Primary Granulocytopenia (Agranulocytic Angina) , J. A. M. A. 102:755, 1934.Crossref 5. Benjamin, J. E., and Biederman, J. B.: Agranulocytic Leukopenia: Report of Case Successfully Treated with X-Rays and Some Observations on Effect of Amidopyrine , J. A. M. A. 103: 161, 1934.Crossref 6. Dameshek, W., and Colmes, A.: The Effects of Drugs in the Production of Agranulocytosis with Particular Reference to Amidopyrine Hypersensitivity , J. Clin. Invest. 15:85, 1936.Crossref 7. Plum, P.: Clinical and Experimental Investigations in Agranulocytosis , London, H. K. Lewis & Co., Ltd., 1937. 8. Dameshek, W.: Agranulocytosis, in Oxford Loose-Leaf Medicine , edited by H. A. Christian, New York, Oxford University Press, 1944, Vol. 2, Pt. 2. 9. Long, P. H.; Haviland, J. W.; Edwards, L. B., and Bliss, E. A.: The Toxic Manifestations of Sulfanilamide and Its Derivatives, with Reference to Their Importance in Course of Therapy , J. A. M. A. 115:364, 1940.Crossref 10. Moeschlin, S., and Wagner, K.: Agranulocytosis Due to the Occurrence of Leukocyte-Agglutinins (Pyramidon and Cold Agglutinins) , Acta haemat. 8:29, 1952.Crossref 11. Moeschlin, S.: Immunological Granulocytopenia and Agranulocytosis (Clinical Aspects) , Sang 26:32, 1955. 12. Svartz, N.: Salazopyrin, a New Sulfanilamide Preparation , Acta med. scandinav. 110:577, 1942.Crossref 13. Levy, C. W. D.: Agranulocytose ved salazopyrinbruk: Meddeldse om et tilfelle , Tidsskr. norske lægefor. 69:255, 1949. 14. Dausset, J.; Nenna, A., and Brecy, H.: Leukoagglutinins: V. Leukoagglutinins in Chronic Idiopathic or Symptomatic Pancytopenia and in Paroxysmal Nocturnal Hemoglobinuria , Blood 9:696, 1954. 15. Craddock, C. G., Jr.; Perry, S., and Lawrence, J. L.: The Dynamics of Leukopoiesis and Leukocytosis as Studied by Leukophoresis and Isotopic Techniques , J. Clin. Invest. 35:285, 1956.Crossref 16. Koszewski, B. J., and Hubbard, T. F.: Immunologic Agranulocytosis Due to Mercurial Diuretics , Am. J. Med. 20:958, 1956.Crossref

Journal

A.M.A. Archives of Internal MedicineAmerican Medical Association

Published: Feb 1, 1958

References