Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Studies in Hyperbilirubinemia: III. Separate Metabolic Defects in Premature Infants Reflected in the Partition of Serum Bilirubin

Studies in Hyperbilirubinemia: III. Separate Metabolic Defects in Premature Infants Reflected in... Abstract The ability of the fetal and neonatal liver to form glucuronide conjugates with endogenous and exogenous metabolites has been shown to be poor.1-3 Accordingly, current theory holds that inadequate hepatic conjugation of bilirubin is the essential, if not the sole, mechanism responsible for the bilirubinemia of physiologic icterus. This view does not take account of the possible role of extrahepatic processes of conjugation in the metabolism of bilirubin, and, by implication, places the burden of forming bilirubin glucuronides entirely on the liver. It implies further that the neonatal liver has an adequate capacity for the excretion of such quantities of bilirubin as it is able to conjugate. Both premises derive in a large measure from the prevailing concept of the nature of the pigment which accumulates in the body fluids and tissues of the newborn infant. It is more or less explicitly assumed that this pigment is solely or References 1. Dutton, G. J.: Foetal and Gastro-Intestinal Glucuronide Synthesis , Abstract, Biochem. J. 69: 39P ( (July) ) 1958. 2. Lathe, G. H., and Walker, M.: An Enzyme Defect in Human Neonatal Jaundice and in Gunn's Strain of Jaundiced Rats , Biochem. J. 67:9P ( (Sept.) ) 1957. 3. Brown, A. K., and Zuelzer, W. W.: Studies on the Neonatal Development of the Glucuronide Conjugating System , J. Clin. Invest. 37:332-340 ( (March) ) 1958.Crossref 4. Billing, B. H., and Lathe, G. H.: The Excretion of Bilirubin as an Ester Glucuronide, Giving the Direct van den Bergh Reaction , Abstract, Biochem. J. 63:6P ( (May) ) 1956. 5. Zuelzer, W. W., and Brown, A. K.: Neonatal Jaundice: A Review , Amer. J. Dis. Child. 101: 87-127 ( (Jan.) ) 1961.Crossref 6. Hoffman, M. N., II; Whitcomb, F. F., Jr.; Butt, H. R., and Bollman, J. L.: Bile Pigments of Jaundice , J. Clin. Invest. 39:132-142 ( (Jan.) ) 1960.Crossref 7. Schoenfield, L. J.; Grindlay, J. H.; Foulk, W. T., and Bollman, J. L.: Identification of Extrahepatic Bilirubin Monoglucuronide and Its Conversion to Pigment 2 by Isolated Liver , Proc. Soc. Exp. Biol. Med. 106:438-441 ( (Feb.) ) 1961.Crossref 8. Billing, B. H., and Lathe, G. H.: Bilirubin Metabolism in Jaundice , Amer. J. Med. 24:111-121 ( (Jan.) ) 1958.Crossref 9. Eberlein, W. R.: A Simple Solvent-Partition Method for Measurement of Free and Conjugated Bilirubin in Serum , Pediatrics 25:878-885 ( (May) ) 1960. 10. Brown, A. K., and Zuelzer, W. W.: Studies in Hyperbilirubinemia: I. Hyperbilirubinemia of the Newborn Unrelated to Isoimmunization , A.M.A. J. Dis. Child. 93:263-274 ( (March) ) 1957.Crossref 11. Miller, C. A., and Reed, H. R.: The Relation of Serum Concentrations of Bilirubin to Respiratory Function of Premature Infants , Pediatrics 21:362-369 ( (March) ) 1958. 12. Powell, W. N.: A Method for the Quantitative Determination of Serum Bilirubin with the Photoelectric Colorimeter , Amer. J. Clin. Path., Tech. Sect. 8:55, 1944 13. with Amer. J. Clin. Path. 1944, Vol. 14. 14. Brown, A. K.; Zuelzer, W. W., and Robinson, A. R.: Studies in Hyperbilirubinemia: II. Clearance of Bilirubin from Plasma and Extravascular Space in Newborn Infants During Exchange Transfusion , A.M.A. J. Dis. Child. 93: 274-286 ( (March) ) 1957.Crossref 15. Mott, J. C.: The Ability of Young Mammals to Withstand Total Oxygen Lack , Brit. Med. Bull. 17:144-148 ( (May) ) 1961. 16. Waters, W. J., and Bowen, W. R.: Bilirubin Encephalopathy: Studies Related to Cellular Respiration , Abstract, A.M.A. Amer. J. Dis. Child. 90:603 ( (Nov.) ) 1955. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Studies in Hyperbilirubinemia: III. Separate Metabolic Defects in Premature Infants Reflected in the Partition of Serum Bilirubin

Download PDF
28 pages

Loading next page...
 
/lp/american-medical-association/studies-in-hyperbilirubinemia-iii-separate-metabolic-defects-in-LYJPmgFIVq

References (14)

Publisher
American Medical Association
Copyright
Copyright © 1961 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1961.02080010817005
Publisher site
See Article on Publisher Site

Abstract

Abstract The ability of the fetal and neonatal liver to form glucuronide conjugates with endogenous and exogenous metabolites has been shown to be poor.1-3 Accordingly, current theory holds that inadequate hepatic conjugation of bilirubin is the essential, if not the sole, mechanism responsible for the bilirubinemia of physiologic icterus. This view does not take account of the possible role of extrahepatic processes of conjugation in the metabolism of bilirubin, and, by implication, places the burden of forming bilirubin glucuronides entirely on the liver. It implies further that the neonatal liver has an adequate capacity for the excretion of such quantities of bilirubin as it is able to conjugate. Both premises derive in a large measure from the prevailing concept of the nature of the pigment which accumulates in the body fluids and tissues of the newborn infant. It is more or less explicitly assumed that this pigment is solely or References 1. Dutton, G. J.: Foetal and Gastro-Intestinal Glucuronide Synthesis , Abstract, Biochem. J. 69: 39P ( (July) ) 1958. 2. Lathe, G. H., and Walker, M.: An Enzyme Defect in Human Neonatal Jaundice and in Gunn's Strain of Jaundiced Rats , Biochem. J. 67:9P ( (Sept.) ) 1957. 3. Brown, A. K., and Zuelzer, W. W.: Studies on the Neonatal Development of the Glucuronide Conjugating System , J. Clin. Invest. 37:332-340 ( (March) ) 1958.Crossref 4. Billing, B. H., and Lathe, G. H.: The Excretion of Bilirubin as an Ester Glucuronide, Giving the Direct van den Bergh Reaction , Abstract, Biochem. J. 63:6P ( (May) ) 1956. 5. Zuelzer, W. W., and Brown, A. K.: Neonatal Jaundice: A Review , Amer. J. Dis. Child. 101: 87-127 ( (Jan.) ) 1961.Crossref 6. Hoffman, M. N., II; Whitcomb, F. F., Jr.; Butt, H. R., and Bollman, J. L.: Bile Pigments of Jaundice , J. Clin. Invest. 39:132-142 ( (Jan.) ) 1960.Crossref 7. Schoenfield, L. J.; Grindlay, J. H.; Foulk, W. T., and Bollman, J. L.: Identification of Extrahepatic Bilirubin Monoglucuronide and Its Conversion to Pigment 2 by Isolated Liver , Proc. Soc. Exp. Biol. Med. 106:438-441 ( (Feb.) ) 1961.Crossref 8. Billing, B. H., and Lathe, G. H.: Bilirubin Metabolism in Jaundice , Amer. J. Med. 24:111-121 ( (Jan.) ) 1958.Crossref 9. Eberlein, W. R.: A Simple Solvent-Partition Method for Measurement of Free and Conjugated Bilirubin in Serum , Pediatrics 25:878-885 ( (May) ) 1960. 10. Brown, A. K., and Zuelzer, W. W.: Studies in Hyperbilirubinemia: I. Hyperbilirubinemia of the Newborn Unrelated to Isoimmunization , A.M.A. J. Dis. Child. 93:263-274 ( (March) ) 1957.Crossref 11. Miller, C. A., and Reed, H. R.: The Relation of Serum Concentrations of Bilirubin to Respiratory Function of Premature Infants , Pediatrics 21:362-369 ( (March) ) 1958. 12. Powell, W. N.: A Method for the Quantitative Determination of Serum Bilirubin with the Photoelectric Colorimeter , Amer. J. Clin. Path., Tech. Sect. 8:55, 1944 13. with Amer. J. Clin. Path. 1944, Vol. 14. 14. Brown, A. K.; Zuelzer, W. W., and Robinson, A. R.: Studies in Hyperbilirubinemia: II. Clearance of Bilirubin from Plasma and Extravascular Space in Newborn Infants During Exchange Transfusion , A.M.A. J. Dis. Child. 93: 274-286 ( (March) ) 1957.Crossref 15. Mott, J. C.: The Ability of Young Mammals to Withstand Total Oxygen Lack , Brit. Med. Bull. 17:144-148 ( (May) ) 1961. 16. Waters, W. J., and Bowen, W. R.: Bilirubin Encephalopathy: Studies Related to Cellular Respiration , Abstract, A.M.A. Amer. J. Dis. Child. 90:603 ( (Nov.) ) 1955.

Journal

American Journal of Diseases of Children – American Medical Association

Published: Dec 1, 1961

There are no references for this article.