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STUDIES IN EXPERIMENTAL TRAUMATIC SHOCK: VIII. THE INFLUENCE OF MORPHIN ON THE BLOOD PRESSURE AND ALKALI RESERVE IN TRAUMATIC SHOCK

STUDIES IN EXPERIMENTAL TRAUMATIC SHOCK: VIII. THE INFLUENCE OF MORPHIN ON THE BLOOD PRESSURE AND... Abstract Morphin was used extensively in the treatment of the wounded during the recent war, and at the present time it is almost routinely employed by many surgeons preparatory to operative procedures in civilian practice. The experiments herein reported were made in an attempt to determine the influence of morphin on the development of shock. The problem was studied from the point of view of a possible influence on the blood pressure and on the carbon dioxid capacity of the blood. Most of the observations were made at the Central Medical Department Laboratory, Dijon, France, during the summer of 1918. Preliminary reports1 have already been published, since which time a number of other articles have been added to the literature on the subject, and it seems worth while to present the results of these experiments in more detail. THE EFFECT OF MORPHIN ON THE BLOOD PRESSURE Literature. —The early work References 1. Cattell, McKeen: Am. J. Physiol. 51:197, 1920. 2. Cannon, W. B., and Cattell, McKeen: Experimental Traumatic Shock , Arch. Surg. 4:316 ( (March) ) 1922. 3. Witkowski: Arch. f. exper. Path. u. Pharmakol. 7:47, 1877.Crossref 4. Cushny, A. R.: Textbook of Pharmacology and Therapeutics , Ed. 7. Philadelphia, Lea & Febiger, 1918, p. 247. 5. Macht, D. I.: J. of Pharm. & Exper. Therap. 11:389 ( (June) ) 1918. 6. Okamoto, S.: Acta scholae med. univ. imp., Kioto 2:307 ( (March) ) 1918. 7. Geschleiden: Unters. auf dem physiol. Lab. 2:1, 1869. 8. Anders: Arch. f. exper. Path. u. Pharmakol. 72:331, 1913. 9. Van Egmond: Arch. f. exper. Path. u. Pharmakol. 65:197, 1911. 10. Guinard: Thèse de Lyon, 1898. 11. Einthoven, W., and Weiringa, J. H.: Arch. f. d. ges. Physiol. 149:48, 1912. 12. Eyster and Meek: J. Pharmacol. & Exper. Therap. 3:468, 1912. 13. Vinci: Arch. internat. de pharmacol. 17:5, 1907. 14. Snyder, C. D., and Andrus, E. C.: J. Pharmacol. & Exper. Therap. 14:1 ( (Sept.) ) 1919. 15. Hanzlik, P. J.: J. Pharmacol. & Exper. Therap. 17:445 ( (July) ) 1921. 16. Christeller: Ztschr. f. Klin. Med. 3:33, 1881. 17. Frenkel: Deutsch. Arch. f. klin. Med. 46:542, 1890. 18. Capps, J. A., and Matthews, S. A.: Venous Blood Pressure as Influenced by the Drugs Employed in Cardiovascular Therapy , J. A. M. A. 61:388 ( (Aug. 9) ) 1913. 19. Cannon, W. B., and Cattell, McKeen (Footnote 1, second reference). 20. Filehne and Kionka: Arch. f. d. ges. Physiol. 62:201, 1895. 21. Barbour, Maurer and von Glahn: J. Pharm. & Exper. Therap. 8:124, 1916. 22. Underhill, Blatherwick and Goldschmidt: Proc. Soc. Exper. Biol. & Med. 14:83, 1917. 23. Henderson, L. J., and Haggard, H. W.: J. Biol. Chem. 33:333 ( (Feb.) ) 1918. 24. Hjort, A. M., and Taylor, F. A.: J. Pharmcol. & Exper. Therap. 13:407 ( (Aug.) ) 1919. 25. Gauss, H.: J. Pharmacol. & Exper. Therap. 16:475 ( (Jan.) ) 1921. 26. Stehle, R. L., Bourne, W. and Barbour, H. G.: J. Biol. Chem. 53:341 ( (Aug.) ) 1922. 27. Van Slyke, D. D.: J. Biol. Chem. 30:347 ( (June) ) 1917. 28. Boeck and Bauer: Ztschr. f. Biol. 10:336, 1874. 29. Voit, Carl: Handbuch der Physiologie , Leipzig, F. C. W. Vogel, 1881, p. 178. 30. Fubini: Untersuch. z. Naturl. d. Mensch. u. d. Thiere 12:563, 1881. 31. Gréhant: Comp. rend. Soc. de Biol. 110:221, 1882. 32. Impens: Arch. f. d. ges. Physiol. 78:527, 1899. 33. Dreser: Arch. f. d. ges. Physiol. 72:72, 1898. 34. Tangl and Versar: Biochem. Ztschr. 92:318, 1918. 35. Loewy: Berl. klin. Wchnschr. 28:434, 1891. 36. Higgins, H. L., and Means, J. H.: J. Pharm. & Exper. Therap. 7:1, 1915. 37. Chanutin, A., and Lusk, G.: J. Pharm. Exper. & Therap. 19:359 ( (June) ) 1922. 38. Aub, J. C.: Am. J. Physiol. 54:388 ( (Dec.) ) 1920. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

STUDIES IN EXPERIMENTAL TRAUMATIC SHOCK: VIII. THE INFLUENCE OF MORPHIN ON THE BLOOD PRESSURE AND ALKALI RESERVE IN TRAUMATIC SHOCK

Archives of Surgery , Volume 7 (1) – Jul 1, 1923

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Publisher
American Medical Association
Copyright
Copyright © 1923 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1923.01120010099006
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Abstract

Abstract Morphin was used extensively in the treatment of the wounded during the recent war, and at the present time it is almost routinely employed by many surgeons preparatory to operative procedures in civilian practice. The experiments herein reported were made in an attempt to determine the influence of morphin on the development of shock. The problem was studied from the point of view of a possible influence on the blood pressure and on the carbon dioxid capacity of the blood. Most of the observations were made at the Central Medical Department Laboratory, Dijon, France, during the summer of 1918. Preliminary reports1 have already been published, since which time a number of other articles have been added to the literature on the subject, and it seems worth while to present the results of these experiments in more detail. THE EFFECT OF MORPHIN ON THE BLOOD PRESSURE Literature. —The early work References 1. Cattell, McKeen: Am. J. Physiol. 51:197, 1920. 2. Cannon, W. B., and Cattell, McKeen: Experimental Traumatic Shock , Arch. Surg. 4:316 ( (March) ) 1922. 3. Witkowski: Arch. f. exper. Path. u. Pharmakol. 7:47, 1877.Crossref 4. Cushny, A. R.: Textbook of Pharmacology and Therapeutics , Ed. 7. Philadelphia, Lea & Febiger, 1918, p. 247. 5. Macht, D. I.: J. of Pharm. & Exper. Therap. 11:389 ( (June) ) 1918. 6. Okamoto, S.: Acta scholae med. univ. imp., Kioto 2:307 ( (March) ) 1918. 7. Geschleiden: Unters. auf dem physiol. Lab. 2:1, 1869. 8. Anders: Arch. f. exper. Path. u. Pharmakol. 72:331, 1913. 9. Van Egmond: Arch. f. exper. Path. u. Pharmakol. 65:197, 1911. 10. Guinard: Thèse de Lyon, 1898. 11. Einthoven, W., and Weiringa, J. H.: Arch. f. d. ges. Physiol. 149:48, 1912. 12. Eyster and Meek: J. Pharmacol. & Exper. Therap. 3:468, 1912. 13. Vinci: Arch. internat. de pharmacol. 17:5, 1907. 14. Snyder, C. D., and Andrus, E. C.: J. Pharmacol. & Exper. Therap. 14:1 ( (Sept.) ) 1919. 15. Hanzlik, P. J.: J. Pharmacol. & Exper. Therap. 17:445 ( (July) ) 1921. 16. Christeller: Ztschr. f. Klin. Med. 3:33, 1881. 17. Frenkel: Deutsch. Arch. f. klin. Med. 46:542, 1890. 18. Capps, J. A., and Matthews, S. A.: Venous Blood Pressure as Influenced by the Drugs Employed in Cardiovascular Therapy , J. A. M. A. 61:388 ( (Aug. 9) ) 1913. 19. Cannon, W. B., and Cattell, McKeen (Footnote 1, second reference). 20. Filehne and Kionka: Arch. f. d. ges. Physiol. 62:201, 1895. 21. Barbour, Maurer and von Glahn: J. Pharm. & Exper. Therap. 8:124, 1916. 22. Underhill, Blatherwick and Goldschmidt: Proc. Soc. Exper. Biol. & Med. 14:83, 1917. 23. Henderson, L. J., and Haggard, H. W.: J. Biol. Chem. 33:333 ( (Feb.) ) 1918. 24. Hjort, A. M., and Taylor, F. A.: J. Pharmcol. & Exper. Therap. 13:407 ( (Aug.) ) 1919. 25. Gauss, H.: J. Pharmacol. & Exper. Therap. 16:475 ( (Jan.) ) 1921. 26. Stehle, R. L., Bourne, W. and Barbour, H. G.: J. Biol. Chem. 53:341 ( (Aug.) ) 1922. 27. Van Slyke, D. D.: J. Biol. Chem. 30:347 ( (June) ) 1917. 28. Boeck and Bauer: Ztschr. f. Biol. 10:336, 1874. 29. Voit, Carl: Handbuch der Physiologie , Leipzig, F. C. W. Vogel, 1881, p. 178. 30. Fubini: Untersuch. z. Naturl. d. Mensch. u. d. Thiere 12:563, 1881. 31. Gréhant: Comp. rend. Soc. de Biol. 110:221, 1882. 32. Impens: Arch. f. d. ges. Physiol. 78:527, 1899. 33. Dreser: Arch. f. d. ges. Physiol. 72:72, 1898. 34. Tangl and Versar: Biochem. Ztschr. 92:318, 1918. 35. Loewy: Berl. klin. Wchnschr. 28:434, 1891. 36. Higgins, H. L., and Means, J. H.: J. Pharm. & Exper. Therap. 7:1, 1915. 37. Chanutin, A., and Lusk, G.: J. Pharm. Exper. & Therap. 19:359 ( (June) ) 1922. 38. Aub, J. C.: Am. J. Physiol. 54:388 ( (Dec.) ) 1920.

Journal

Archives of SurgeryAmerican Medical Association

Published: Jul 1, 1923

References