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STUDIES IN EXHAUSTION: VII. AUTOINTOXICATION

STUDIES IN EXHAUSTION: VII. AUTOINTOXICATION Abstract A state of autointoxication may result (a) from the retention of waste products; (b) from arrested catabolism, especially of proteins; (c) from the formation of certain complex substances as the result of faulty action on the part of some organ; (d) from toxic substances, presumably produced by intestinal bacteria, which are absorbed when normal elimination is completely arrested as in acute intestinal obstruction. Whatever its apparent cause, however, the outstanding symptoms in each case are the same, lassitude, increasing debility, and psychic disturbances which vary from nervous irritability to delirium, headache, and slight fever. Why any of these causes should produce these symptoms has not been clear. In this connection, a recent writer on this subject makes the following statements:1 "We are still uncertain concerning the precise cause of the symptoms in prolonged anuria... The possibility of an autointoxication from the absorption of injurious compounds in the large intestines References 1. Hewlett, A. W.: The Oxford Medicine , London, Oxford University Press 1:60-66, 1920. 2. Crile, G. W.: Anemia and Resuscitation , New York, D. Appleton & Co., 1914, pp. 150-194. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

STUDIES IN EXHAUSTION: VII. AUTOINTOXICATION

Archives of Surgery , Volume 9 (2) – Sep 1, 1924

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Publisher
American Medical Association
Copyright
Copyright © 1924 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1924.01120080059005
Publisher site
See Article on Publisher Site

Abstract

Abstract A state of autointoxication may result (a) from the retention of waste products; (b) from arrested catabolism, especially of proteins; (c) from the formation of certain complex substances as the result of faulty action on the part of some organ; (d) from toxic substances, presumably produced by intestinal bacteria, which are absorbed when normal elimination is completely arrested as in acute intestinal obstruction. Whatever its apparent cause, however, the outstanding symptoms in each case are the same, lassitude, increasing debility, and psychic disturbances which vary from nervous irritability to delirium, headache, and slight fever. Why any of these causes should produce these symptoms has not been clear. In this connection, a recent writer on this subject makes the following statements:1 "We are still uncertain concerning the precise cause of the symptoms in prolonged anuria... The possibility of an autointoxication from the absorption of injurious compounds in the large intestines References 1. Hewlett, A. W.: The Oxford Medicine , London, Oxford University Press 1:60-66, 1920. 2. Crile, G. W.: Anemia and Resuscitation , New York, D. Appleton & Co., 1914, pp. 150-194.

Journal

Archives of SurgeryAmerican Medical Association

Published: Sep 1, 1924

References