Abstract Results of cephalexin monohydrate and potassium phenoxymethyl penicillin were compared in children with pharyngitis and group A streptococci in two consecutive studies, 1968 to 1969 and 1969 to 1970. Ampicillin anhydrous was included in the first study. The patients were assigned randomly to one of the antibiotics, 0.5 gm daily for ten days. Recurrences, detected by routine weekly cultures, of the original group A streptococcal types within three weeks after end of treatment were classified as failures. The failure rates in the first study were 11% (4/38) for cephalexin, 26% (10/39) for phenoxymethyl penicillin, and 27% (10/27) for ampicillin. The failure rates in the second study were 9% (4/46) for cephalexin and 20% (10/50) for potassium phenoxymethyl penicillin. In the combined studies cephalexin was more effective than potassium phenoxymethyl penicillin (P <.05). References 1. Wick WE: Cephalexin, a new orally absorbed cephalosporin antibiotic . Appl Microbiol 15:765-769, 1967. 2. Leiderman E, Stowe FR, Mogabgab WJ: Cephaloglycin and cephalexin in betahemolytic streptococcal pharyngitis . Clin Med 77:27-32, 1970. 3. Stillerman M: Comparison of cephaloglycin and penicillin in streptococcal pharyngitis . Clin Pharmacol Ther 11:205-213, 1970. 4. Breese BB, Disney FA, Talpey WB: Betahemolytic streptococcal illness: Comparison of lincomycin, ampicillin and potassium penicillin G in treatment . Amer J Dis Child 112:21-27, 1966. 5. Stillerman M, Isenberg HD: Streptococcal pharyngitis therapy: Comparison of cyclacillin, cephalexin, and K penicillin V . Antimicrob Agents Chemother , 270-276, 1970. 6. Muggleton PW, O'Callaghan CH, Foord RD, et al: Laboratory appraisal of cephalexin . Antimicrob Agents Chemother , 353-360, 1968. 7. Griffith RS, Black HR: Cephalexin: A new antibiotic . Clin Med 75:14-22, 1968. 8. Kind AC, Kestle DG, Standiford HC, et al: Laboratory and clinical experience with cephalexin . Antimicrob Agents Chemother , 361-365, 1968. 9. Kunin CM: Clinical significance of protein binding of the penicillins . Ann NY Acad Sci 145:282-290, 1967.Crossref 10. Stillerman M, Bernstein SH: Streptococcal pharyngitis: Evaluation of clinical syndromes in diagnosis . Amer J Dis Child 101:476-489, 1961. 11. Moody MD, Padula J, Lizana D, et al: Epidemiologic characterization of group A streptococci by T-agglutination and M-precipitation tests in the public health laboratory . Health Lab Sci 2:149-162, 1965. 12. Stillerman M, Bernstein SH: Streptococcal pharyngitis therapy . Amer J Dis Child 107:35-46, 1964. 13. Isenberg HD: Tube dilution susceptibility response of clinically isolated staphylococci from several countries to three penicillins and triacetyloleandomycin . Antimicrob Agents Chemother , 377-383, 1964. 14. Levine BB: Immunologic manifestations of penicillin allergy: A haptogenic model system for the study of allergic diseases of man . New Eng J Med 275:1115-1125, 1966.Crossref 15. Stewart GT: Macromolecular residues contributing to the allergenicity of penicillins and cephalosporins . Antimicrob Agents Chemother , 543-549, 1967. 16. Shapiro S, Siskind V, Slome D, et al: Drug rash with ampicillin and other penicillins . Lancet 2:969-972, 1969.Crossref 17. Disney FA, Breese BB, Green JL, et al: Cephalexin and penicillin therapy of childhood beta-hemolytic streptococcal infections . Postgrad Med J 47 ( (suppl) ):47-51, 1971.
American Journal of Diseases of Children – American Medical Association
Published: May 1, 1972