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- Publisher
- American Medical Association
- Copyright
- Copyright © 1929 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
- ISSN
- 0098-7484
- eISSN
- 1538-3598
- DOI
- 10.1001/jama.1929.02710260015006
- Publisher site
- See Article on Publisher Site
Abstract
The picture of the sequelae of epidemic encephalitis is well known. The disease is usually followed for a period of a few months to several years by seemingly complete recovery, often to be interrupted by one of the many variations of the parkinsonian syndrome, varying combinations of the symptoms of tremor, muscular rigidity, propulsion, bradykinesia, mental retardation, fatigability, myalgia, dysphagia, ptyalism, hyperhidrosis, the assumption of postures resembling catatonia, and, in some cases, pareses. Every physician is aware of the devastating influence of these sequelae, both with and without treatment. Except for the limited value of scopolamine in diminishing tremor, no remedial or alleviating agents have been in general use. Many therapeutic agents have been advocated as beneficial, including malarial inoculation,1 nicotine,2 sodium salicylate3 and others, all with only slight, or no benefit. Not until the various alkaloids of the Solanaceae were used was any noteworthy benefit observed.
Journal
JAMA – American Medical Association
Published: Dec 28, 1929