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STEVENS-JOHNSON SYNDROME: Report of Nine Patients Treated with Sulfonamide Drugs or Penicillin

STEVENS-JOHNSON SYNDROME: Report of Nine Patients Treated with Sulfonamide Drugs or Penicillin Abstract STEVENS and Johnson1 in 1922 described a "new" eruptive fever associated with stomatitis, ophthalmia, cutaneous eruption and constitutional symptoms. This syndrome is usually considered uncommon; we have seen but 15 patients with it out of 115,000 patients admitted to the hospital since September 1942, 6 of whom had only simple catarrhal conjunctivitis and are not included in this report. This syndrome deserves more emphasis because tragic complications of the eyes, consisting of corneal ulceration or panophthalmitis with partial or complete loss of vision, have been frequent in reported cases. Since these severe complications of the eyes did not occur in our 9 patients treated with sulfonamide drugs and/or penicillin, we feel that their cases should be reported. Stevens-Johnson syndrome has been referred to as erythema multiforme bullosum with involvement of the mucous membranes of the eyes and mouth,2 erythema exudativum multiforme with opthalmia and stomatitis3 or severe References 1. Stevens, A. M., and Johnson, F. C.: New Eruptive Fever Associated with Stomatitis and Ophthalmia , Am. J. Dis. Child. 24:526 ( (Dec.) ) 1922.Crossref 2. Ageloff, H.: Erythema Multiforme Bullosum with Involvement of Mucous Membranes of Eyes and Mouth (Stevens-Johnson's Disease): Report of a Case , New England J. Med. 223:217 ( (Aug. 8) ) 1940.Crossref 3. Edgar, K. J., and Syverton, J. T.: Erythema Exudativum Multiforme with Ophthalmia and Stomatitis: Report on Two cases in Children with Certain Observations on Histopathology and Animal Inoculation , J. Pediat. 12:151 ( (Feb.) ) 1938.Crossref 4. Lever, W. F.: Severe Erythema Multiforme: Report of Two Cases of the Type Ectodermosis Erosiva Pluriorificialis, with Development of Cicatricial Conjunctivitis and Keratitis in One case , Arch. Dermat. & Syph. 49:47 ( (Jan.) ) 1944. 5. Bailey, J. H.: Lesions of Cornea and Conjunctiva in Erythema Exudativum Multiforme (Hebra): Report of Three Cases with Grave Ocular Sequelae , Arch. Ophth 6:362 ( (Sept.) ) 1931. 6. Ginandes, G. J.: Eruptive Fever with Stomatitis and Ophthalmia: Atypical Erythema Exudativum Multiforme (Stevens-Johnson Syndrome) , Am. J. Dis. Child. 49:1148 ( (May) ) 1935. 7. Klauder, J. V.: Ectodermosis Erosiva Pluriorificialis: Its Resemblance to the Human Form of Foot and Mouth Disease and Its Relation to Erythema Exudativum Multiforme , Arch. Dermat. & Syph. 36:1067 ( (Nov.) ) 1937. 8. Givner, I., and Ageloff, H.: Stevens-Johnson Disease with Complete Visual Recovery , New York State J. Med. 41:1762 ( (Sept. 1) ) 1941. 9. Erger, B. D.: Erythema Multiforme Pluriorificialis (Stevens-Johnson Disease) , Mil. Surgeon 95:308 ( (Oct.) ) 1944. 10. Kove, S.: Stevens-Johnson Syndrome (Eruptive Fever with Stomatitis and Conjunctivitis) , Am. J. M. Sc. 210:611 ( (Nov.) ) 1945. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

STEVENS-JOHNSON SYNDROME: Report of Nine Patients Treated with Sulfonamide Drugs or Penicillin

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American Medical Association
Copyright
Copyright © 1947 American Medical Association. All Rights Reserved.
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0730-188X
DOI
10.1001/archinte.1947.00220110050003
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Abstract

Abstract STEVENS and Johnson1 in 1922 described a "new" eruptive fever associated with stomatitis, ophthalmia, cutaneous eruption and constitutional symptoms. This syndrome is usually considered uncommon; we have seen but 15 patients with it out of 115,000 patients admitted to the hospital since September 1942, 6 of whom had only simple catarrhal conjunctivitis and are not included in this report. This syndrome deserves more emphasis because tragic complications of the eyes, consisting of corneal ulceration or panophthalmitis with partial or complete loss of vision, have been frequent in reported cases. Since these severe complications of the eyes did not occur in our 9 patients treated with sulfonamide drugs and/or penicillin, we feel that their cases should be reported. Stevens-Johnson syndrome has been referred to as erythema multiforme bullosum with involvement of the mucous membranes of the eyes and mouth,2 erythema exudativum multiforme with opthalmia and stomatitis3 or severe References 1. Stevens, A. M., and Johnson, F. C.: New Eruptive Fever Associated with Stomatitis and Ophthalmia , Am. J. Dis. Child. 24:526 ( (Dec.) ) 1922.Crossref 2. Ageloff, H.: Erythema Multiforme Bullosum with Involvement of Mucous Membranes of Eyes and Mouth (Stevens-Johnson's Disease): Report of a Case , New England J. Med. 223:217 ( (Aug. 8) ) 1940.Crossref 3. Edgar, K. J., and Syverton, J. T.: Erythema Exudativum Multiforme with Ophthalmia and Stomatitis: Report on Two cases in Children with Certain Observations on Histopathology and Animal Inoculation , J. Pediat. 12:151 ( (Feb.) ) 1938.Crossref 4. Lever, W. F.: Severe Erythema Multiforme: Report of Two Cases of the Type Ectodermosis Erosiva Pluriorificialis, with Development of Cicatricial Conjunctivitis and Keratitis in One case , Arch. Dermat. & Syph. 49:47 ( (Jan.) ) 1944. 5. Bailey, J. H.: Lesions of Cornea and Conjunctiva in Erythema Exudativum Multiforme (Hebra): Report of Three Cases with Grave Ocular Sequelae , Arch. Ophth 6:362 ( (Sept.) ) 1931. 6. Ginandes, G. J.: Eruptive Fever with Stomatitis and Ophthalmia: Atypical Erythema Exudativum Multiforme (Stevens-Johnson Syndrome) , Am. J. Dis. Child. 49:1148 ( (May) ) 1935. 7. Klauder, J. V.: Ectodermosis Erosiva Pluriorificialis: Its Resemblance to the Human Form of Foot and Mouth Disease and Its Relation to Erythema Exudativum Multiforme , Arch. Dermat. & Syph. 36:1067 ( (Nov.) ) 1937. 8. Givner, I., and Ageloff, H.: Stevens-Johnson Disease with Complete Visual Recovery , New York State J. Med. 41:1762 ( (Sept. 1) ) 1941. 9. Erger, B. D.: Erythema Multiforme Pluriorificialis (Stevens-Johnson Disease) , Mil. Surgeon 95:308 ( (Oct.) ) 1944. 10. Kove, S.: Stevens-Johnson Syndrome (Eruptive Fever with Stomatitis and Conjunctivitis) , Am. J. M. Sc. 210:611 ( (Nov.) ) 1945.

Journal

Archives of Internal Medicine – American Medical Association

Published: May 1, 1947

References

  • New Eruptive Fever Associated with Stomatitis and Ophthalmia
    Stevens , A. M., and Johnson, F. C.
  • Erythema Multiforme Bullosum with Involvement of Mucous Membranes of Eyes and Mouth (Stevens-Johnson's Disease): Report of a Case
    Ageloff , H.
  • Erythema Exudativum Multiforme with Ophthalmia and Stomatitis: Report on Two cases in Children with Certain Observations on Histopathology and Animal Inoculation
    Edgar , K. J., and Syverton, J. T.
  • Severe Erythema Multiforme: Report of Two Cases of the Type Ectodermosis Erosiva Pluriorificialis, with Development of Cicatricial Conjunctivitis and Keratitis in One case
    Lever , W. F.
  • Lesions of Cornea and Conjunctiva in Erythema Exudativum Multiforme (Hebra): Report of Three Cases with Grave Ocular Sequelae
    Bailey , J. H.
  • Eruptive Fever with Stomatitis and Ophthalmia: Atypical Erythema Exudativum Multiforme (Stevens-Johnson Syndrome)
    Ginandes , G. J.
  • Ectodermosis Erosiva Pluriorificialis: Its Resemblance to the Human Form of Foot and Mouth Disease and Its Relation to Erythema Exudativum Multiforme
    Klauder , J. V.
  • Stevens-Johnson Disease with Complete Visual Recovery
    Givner , I., and Ageloff, H.
  • Erythema Multiforme Pluriorificialis (Stevens-Johnson Disease)
    Erger , B. D.
  • Stevens-Johnson Syndrome (Eruptive Fever with Stomatitis and Conjunctivitis)
    Kove , S.