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STERILITY AFTER RADIOIODINE THERAPY FOR METASTATIC THYROID CARCINOMA

STERILITY AFTER RADIOIODINE THERAPY FOR METASTATIC THYROID CARCINOMA Radioiodine (I131) has been used in the treatment of thyroid cancer metastases since 1943. The harmful radiation effects of this agent on the blood-forming organs are well recognized, but other body structures are seldom injured. Reports of permanent damage to the reproductive organs by I131 are exceedingly rare. The case we are reporting seems to represent a clear instance of injury to the testes from radioiodine administered as treatment for metastatic thyroid carcinoma. Report of a Case A 24-year-old man was found during the course of a routine x-ray examination of the chest in March, 1952, to have widespread diffuse nodular densities in both lung fields (fig. 1). He felt entirely well at this time, had lost no weight, and had no respiratory symptoms whatever. It was known that a roentgenogram of the chest in 1949 had shown no abnormalities. Physical examination was entirely negative except for a http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

STERILITY AFTER RADIOIODINE THERAPY FOR METASTATIC THYROID CARCINOMA

JAMA , Volume 171 (14) – Dec 5, 1959

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Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1959.73010320001013
Publisher site
See Article on Publisher Site

Abstract

Radioiodine (I131) has been used in the treatment of thyroid cancer metastases since 1943. The harmful radiation effects of this agent on the blood-forming organs are well recognized, but other body structures are seldom injured. Reports of permanent damage to the reproductive organs by I131 are exceedingly rare. The case we are reporting seems to represent a clear instance of injury to the testes from radioiodine administered as treatment for metastatic thyroid carcinoma. Report of a Case A 24-year-old man was found during the course of a routine x-ray examination of the chest in March, 1952, to have widespread diffuse nodular densities in both lung fields (fig. 1). He felt entirely well at this time, had lost no weight, and had no respiratory symptoms whatever. It was known that a roentgenogram of the chest in 1949 had shown no abnormalities. Physical examination was entirely negative except for a

Journal

JAMAAmerican Medical Association

Published: Dec 5, 1959

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