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Statistical Indiscretion-Reply

Statistical Indiscretion-Reply In Reply.— The study referred to in the previous letter is the first double-blind investigation of these drugs for the treatment of status epilepticus, and we are pleased that Dr Lee found only a minor statement that displeased him. Diazepam attained wide use for treatment of status without any controlled trials, and our study was designed to determine if lorazepam was as effective and safe as current treatment. The favorable outcome of our study has permitted other trials designed to determine the duration of action of lorazepam to proceed. Thus, while our study did not demonstrate a statistically significant difference between the two drugs, we believe, as does Dr Relman,1 that "there is need also for preliminary but provocative new data" to be reported. The readers of The Journal, we believe, are aware of the implications of trends that have not achieved statistical significance and will be anticipating further http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Statistical Indiscretion-Reply

Leppik, Ilo E.; Derivan, Albert T.
JAMA , Volume 250 (18) – Nov 11, 1983
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Statistical Indiscretion-Reply

Abstract



In Reply.—
The study referred to in the previous letter is the first double-blind investigation of these drugs for the treatment of status epilepticus, and we are pleased that Dr Lee found only a minor statement that displeased him. Diazepam attained wide use for treatment of status without any controlled trials, and our study was designed to determine if lorazepam was as effective and safe as current treatment. The favorable outcome of our study has permitted other trials designed to...
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References (1)

Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1983.03340180032014
Publisher site
See Article on Publisher Site

Abstract

In Reply.— The study referred to in the previous letter is the first double-blind investigation of these drugs for the treatment of status epilepticus, and we are pleased that Dr Lee found only a minor statement that displeased him. Diazepam attained wide use for treatment of status without any controlled trials, and our study was designed to determine if lorazepam was as effective and safe as current treatment. The favorable outcome of our study has permitted other trials designed to determine the duration of action of lorazepam to proceed. Thus, while our study did not demonstrate a statistically significant difference between the two drugs, we believe, as does Dr Relman,1 that "there is need also for preliminary but provocative new data" to be reported. The readers of The Journal, we believe, are aware of the implications of trends that have not achieved statistical significance and will be anticipating further

Journal

JAMA – American Medical Association

Published: Nov 11, 1983

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