Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Statins’ Link to Diabetes Risk Revealed

Statins’ Link to Diabetes Risk Revealed News & Analysis Lab Reports Statins’ Link to Diabetes Risk Revealed have yet to determine the mechanisms in- In research that may help explain the link be- volved in cell injury and the development of tweentheuseofstatinsandanincreasedrisk arrhythmias. for type 2 diabetes, investigators from The newly discovered molecule— McMaster University, in Ontario, Canada, namedSB216763—reducedtheextentofcell have discovered that the drugs activate an injury and cell death and also appeared to re- immune response pathway that interferes verse abnormal electrophysiology in ze- with insulin signaling (Henrikbo BD et al. Dia- brafish cardiac muscle cells. Similar find- betes. doi:10.2337/db13-1398 [published on- ings were observed in rat cells with an ACM line June 10, 2014]). mutationaswellasincardiacmusclecellsde- Experiments in mice revealed that sev- rived from human induced pluripotent stem eral different statins activate a multiprotein cells from 2 patients with ACM. complex—called the NLRP3/caspase-1 in- The treatment involved redistribution of flammasome—known to promote inflam- desmosome proteins within cells, suggest- mation and insulin resistance. ing that ACM mutations lead to defects in Although statin treatment of obese mice desmosome protein trafficking. Lipids known as eicosanoids link 2 impaired insulin signaling and reduced insu- In addition to pointing to a potential new counterregulatory cytokines that affect the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Statins’ Link to Diabetes Risk Revealed

JAMA , Volume 312 (5) – Aug 6, 2014

Statins’ Link to Diabetes Risk Revealed

Abstract

News & Analysis Lab Reports Statins’ Link to Diabetes Risk Revealed have yet to determine the mechanisms in- In research that may help explain the link be- volved in cell injury and the development of tweentheuseofstatinsandanincreasedrisk arrhythmias. for type 2 diabetes, investigators from The newly discovered molecule— McMaster University, in Ontario, Canada, namedSB216763—reducedtheextentofcell have discovered that the drugs activate an injury and cell death and also...
Loading next page...
 
/lp/american-medical-association/statins-link-to-diabetes-risk-revealed-XO4NSF9c9a
Publisher
American Medical Association
Copyright
Copyright 2014 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2014.9731
Publisher site
See Article on Publisher Site

Abstract

News & Analysis Lab Reports Statins’ Link to Diabetes Risk Revealed have yet to determine the mechanisms in- In research that may help explain the link be- volved in cell injury and the development of tweentheuseofstatinsandanincreasedrisk arrhythmias. for type 2 diabetes, investigators from The newly discovered molecule— McMaster University, in Ontario, Canada, namedSB216763—reducedtheextentofcell have discovered that the drugs activate an injury and cell death and also appeared to re- immune response pathway that interferes verse abnormal electrophysiology in ze- with insulin signaling (Henrikbo BD et al. Dia- brafish cardiac muscle cells. Similar find- betes. doi:10.2337/db13-1398 [published on- ings were observed in rat cells with an ACM line June 10, 2014]). mutationaswellasincardiacmusclecellsde- Experiments in mice revealed that sev- rived from human induced pluripotent stem eral different statins activate a multiprotein cells from 2 patients with ACM. complex—called the NLRP3/caspase-1 in- The treatment involved redistribution of flammasome—known to promote inflam- desmosome proteins within cells, suggest- mation and insulin resistance. ing that ACM mutations lead to defects in Although statin treatment of obese mice desmosome protein trafficking. Lipids known as eicosanoids link 2 impaired insulin signaling and reduced insu- In addition to pointing to a potential new counterregulatory cytokines that affect the

Journal

JAMAAmerican Medical Association

Published: Aug 6, 2014

There are no references for this article.