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Starling's Law and Albumin Therapy-Reply

Starling's Law and Albumin Therapy-Reply The ongoing controversy over the relative merits of albumin vs large volumes of crystalloid solution as replacement for effective plasma volume has raged for many decades. Evidence can be cited by proponents of each type of solution. Indeed, the symposium which served as the basis for my communication, carefully presented both sides of this controversy. Although Starling's law of fluid movement across a semipermeable membrane does not fit all experimental conditions, it still remains the keystone for the consideration of movement in and out of the vascular space in isolated organs or extremities. In addition to these interrelating hydrostatic and colloid osmotic pressures on the two sides of a membrane, it is necessary to invoke multiple additional forces. As clearly outlined in the review, these include tissue compliance, rates of lymph flow, changes in capillary permeability, and an intrinsic elastic recoil mechanism of connectivetissue mucopolysaccharides that exhibit inhibition http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Starling's Law and Albumin Therapy-Reply

Tullis, James L.
JAMA , Volume 238 (9) – Aug 29, 1977
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Starling's Law and Albumin Therapy-Reply

Abstract


The ongoing controversy over the relative merits of albumin vs large volumes of crystalloid solution as replacement for effective plasma volume has raged for many decades. Evidence can be cited by proponents of each type of solution. Indeed, the symposium which served as the basis for my communication, carefully presented both sides of this controversy.
Although Starling's law of fluid movement across a semipermeable membrane does not fit all experimental conditions, it still remains...
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Publisher
American Medical Association
Copyright
Copyright © 1977 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1977.03280100020004
Publisher site
See Article on Publisher Site

Abstract

The ongoing controversy over the relative merits of albumin vs large volumes of crystalloid solution as replacement for effective plasma volume has raged for many decades. Evidence can be cited by proponents of each type of solution. Indeed, the symposium which served as the basis for my communication, carefully presented both sides of this controversy. Although Starling's law of fluid movement across a semipermeable membrane does not fit all experimental conditions, it still remains the keystone for the consideration of movement in and out of the vascular space in isolated organs or extremities. In addition to these interrelating hydrostatic and colloid osmotic pressures on the two sides of a membrane, it is necessary to invoke multiple additional forces. As clearly outlined in the review, these include tissue compliance, rates of lymph flow, changes in capillary permeability, and an intrinsic elastic recoil mechanism of connectivetissue mucopolysaccharides that exhibit inhibition

Journal

JAMA – American Medical Association

Published: Aug 29, 1977

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