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Staphylococcus epidermidis in CSF Infections

Staphylococcus epidermidis in CSF Infections Abstract To the Editor. —The recent article of Trump et al, published in the Archives (1982;142:583-586), showed the importance of Staphylococcus epidermidis in CSF infections in patients with subcutaneous reservoirs and ventricular catheters.It was stated that "the pattern of antibiotic sensitivity using a standard in vitro disk method provided useful information regarding the clinical importance of an S epidermidis isolate." Did they indeed use a disk diffusion test and read minimal inhibitory concentrations (MICs) from an interpretive chart or, more likely, did they use a broth dilution technique for MICs?They changed their prophylactic coverage from cephalothin sodium and cephalexin monohydrate therapy to nafcillin sodium therapy because they wanted to use a drug to which the S epidermidis isolates were sensitive. A dose of 2 g of nafcillin sodium intravenously at the time of preparation of the skin for surgery and 1 g every four hours for 24 hours after References 1. Fossieck BE Jr, Kane JG, Diaz CR, et al: Nafcillin entry into human cerebrospinal fluid. Antimicrob Agent Chemother 1977;11:965-967.Crossref 2. Archer GL: Antimicrobial susceptibility and selection of resistance among Staphylococcus epidermidis isolates recovered from patients with infections of indwelling foreign devices. Antimicrob Agent Chemother 1978;14:353-359.Crossref 3. Moellering RC, Krogstad DJ, Greenblatt DJ: Pharmacokinetics of vancomycin in normal subjects and in patients with reduced renal function. Rev Infect Dis 1981;3( (suppl) ):S230-S235.Crossref 4. Gevaci JE, Heilman FR, Nichols DR, et al: Some laboratory and clinical experience with a new antibiotic, vancomycin. Proc Staff Mayo Clinic 1956;31:564-582. 5. Gombert ME, Landesman SH, Corrado ML, et al: Vancomycin and rifampin therapy for Staphylococcus epidermidis meningitis associated with CSF shunts. J Neurosurg 1981;55:633-636.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Staphylococcus epidermidis in CSF Infections

Staphylococcus epidermidis in CSF Infections

Abstract

Abstract To the Editor. —The recent article of Trump et al, published in the Archives (1982;142:583-586), showed the importance of Staphylococcus epidermidis in CSF infections in patients with subcutaneous reservoirs and ventricular catheters.It was stated that "the pattern of antibiotic sensitivity using a standard in vitro disk method provided useful information regarding the clinical importance of an S epidermidis isolate." Did they indeed use a disk diffusion test and read...
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Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1982.00340220184037
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor. —The recent article of Trump et al, published in the Archives (1982;142:583-586), showed the importance of Staphylococcus epidermidis in CSF infections in patients with subcutaneous reservoirs and ventricular catheters.It was stated that "the pattern of antibiotic sensitivity using a standard in vitro disk method provided useful information regarding the clinical importance of an S epidermidis isolate." Did they indeed use a disk diffusion test and read minimal inhibitory concentrations (MICs) from an interpretive chart or, more likely, did they use a broth dilution technique for MICs?They changed their prophylactic coverage from cephalothin sodium and cephalexin monohydrate therapy to nafcillin sodium therapy because they wanted to use a drug to which the S epidermidis isolates were sensitive. A dose of 2 g of nafcillin sodium intravenously at the time of preparation of the skin for surgery and 1 g every four hours for 24 hours after References 1. Fossieck BE Jr, Kane JG, Diaz CR, et al: Nafcillin entry into human cerebrospinal fluid. Antimicrob Agent Chemother 1977;11:965-967.Crossref 2. Archer GL: Antimicrobial susceptibility and selection of resistance among Staphylococcus epidermidis isolates recovered from patients with infections of indwelling foreign devices. Antimicrob Agent Chemother 1978;14:353-359.Crossref 3. Moellering RC, Krogstad DJ, Greenblatt DJ: Pharmacokinetics of vancomycin in normal subjects and in patients with reduced renal function. Rev Infect Dis 1981;3( (suppl) ):S230-S235.Crossref 4. Gevaci JE, Heilman FR, Nichols DR, et al: Some laboratory and clinical experience with a new antibiotic, vancomycin. Proc Staff Mayo Clinic 1956;31:564-582. 5. Gombert ME, Landesman SH, Corrado ML, et al: Vancomycin and rifampin therapy for Staphylococcus epidermidis meningitis associated with CSF shunts. J Neurosurg 1981;55:633-636.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Sep 1, 1982

References