Abstract • Two patients had staphylococcal scalded skin syndrome (SSSS) with typical clinical and histopathologic findings. In both cases, the disease was reproduced by injections of staphylococci into mice. The adult patient, who had no other physical or laboratory abnormalities, showed intact humoral and cellular immunity; her uneventful clinical course was clearly different from the eight previously reported cases in adults. To our knowledge, the child represents the first case report of SSSS as a result of infection by a non-group 2 Staphylococcus. (Arch Dermatol 112:1275-1279, 1976) References 1. Levine G, Norden CW: Staphylococcal scalded-skin syndrome in an adult . N Engl J Med 287:1339-1340, 1972.Crossref 2. Hawley HB, Aronson MD: Scalded-skin syndrome in adults . N Engl J Med 288:1130, 1973. 3. Rothenberg R, Renna FS, Drew TM, et al: Staphyloccocal scalded skin syndrome in an adult . Arch Dermatol 108:408-410, 1973.Crossref 4. Reid LH, Weston WL, Humbert JR: Staphylococcal scalded skin syndrome . Arch Dermatol 109:239-241, 1974.Crossref 5. Norden CW, Mendelow H: Staphylococcal scalded skin syndrome in adults . N Engl J Med 290:577, 1974. 6. Epstein EH, Flynn P, Davis RS: Adult toxic epidermal necrolysis with fatal staphylococcal septicemia . JAMA 229:425-427, 1974.Crossref 7. Trentham DE, Silverman HA, Townes AS: Cause of adult toxic epidermal necrolysis . N Engl J Med 292:870, 1975. 8. Lyell A: Toxic epidermal necrolysis: An eruption resembling scalding of the skin . Br J Dermatol 68:355-361, 1956.Crossref 9. Kondo I, Sakurai S, Sarai Y: Purification of exfoliatin produced by Staphylococcus aureus of bacteriophage group 2 and its physiochemical properties . Infect Immun 8:156-163, 1973. 10. Melish ME, Glasgow LA: The staphylococcal scalded-skin syndrome: Development of an experimental model . N Engl J Med 282:1114-1119, 1970.Crossref 11. Ritter von Rittershain G: Die exfoliative Dermatitis jüngerer Sauglinge , Cent Kinderheilkd 2:3-23, 1878. 12. Lillibridge CB, Melish ME, Glasgow LA: Site of action of exfoliative toxin in the staphylococcal scalded-skin syndrome . Pediatrics 50:728-738, 1972. 13. Elias P, Fritsch P, Tappeiner G, et al: Experimental staphylococcal toxic epidermal necrolysis in adult humans and mice . J Lab Clin Med 84:414-423, 1974. 14. Melish ME, Glasgow LA, Turner MD: Staphylococcal scalded-skin syndrome (SSSS): Experimental model and isolation of a new exfoliative toxin (ET) . Pediatr Res 4:378-379, 1970. 15. Kapral FA, Miller MM: Product of Staphylococcus aureus responsible for the scalded-skin syndrome . Infect Immun 4:541-545, 1971. 16. Arbuthnott JP, Kent J, Lyell A, et al: Toxic epidermal necrolysis produced by an extracellular product of staphylococcus aureus . Br J Dermatol 85:145-149, 1971.Crossref 17. Melish ME, Glasgow LA, Turner MD: The staphylococcal scalded-skin syndrome: Isolation and partial characterization of the exfoliative toxin . J Infect Dis 125:129-139, 1972.Crossref 18. Arbuthnott JP, Kent J, Lyell A, et al: Studies of staphylococcal toxin in relation to toxic epidermal necrolysis (the scalded skin syndrome) . Br J Dermatol 86( (suppl) ):35-39, 1972.Crossref 19. Dick HM, Baird JE: An animal model for staphylococcal toxic epidermal necrolysis . Br J Dermatol 86( (suppl) ):28-34, 1972.Crossref 20. Kondo I, Sakurai S, Sarai Y: New type of exfoliatin obtained from staphylococcal strains, belonging to phage groups other than group II, isolated from patients with impetigo and Ritter's disease . Infect Immun 10:851-861, 1974. 21. Wiley BB, Allman S, Rogolsky M, et al: Staphylococcal scalded skin syndrome: Potentiation by immunosuppression in mice: Toxinmediated exfoliation in a healthy adult . Infect Immun 9:636-647, 1974.
Archives of Dermatology – American Medical Association
Published: Sep 1, 1976