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STANDARDIZATION AND EFFICACY OF BCG VACCINATION AGAINST TUBERCULOSIS

STANDARDIZATION AND EFFICACY OF BCG VACCINATION AGAINST TUBERCULOSIS In evaluating BCG vaccination, one must first define its potentialities. BCG vaccine, properly administered, will increase the resistance of both animal and man to virulent tubercle bacilli. This resistance is not absolute. The degree of resistance that it is possible to develop against tuberculosis may not be as great as for some other disease. Yet it should be borne in mind that there is no disease against which absolute immunity can be achieved. This fact was sharply brought into focus with the report of an epidemic of smallpox among our armed forces in Korea.1 This experience showed that adequate exposure could break down resistance even after multiple vaccinations against smallpox. The potency of the vaccine and the methods of administration were also taken into consideration. In evaluating BCG vaccination, all of these factors must be considered: (1) the vaccine itself, (2) the method of administration, and (3) the degree http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

STANDARDIZATION AND EFFICACY OF BCG VACCINATION AGAINST TUBERCULOSIS

Rosenthal, Sol Roy
JAMA , Volume 157 (10) – Mar 5, 1955
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References (10)

Publisher
American Medical Association
Copyright
Copyright © 1955 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1955.02950270019006
Publisher site
See Article on Publisher Site

Abstract

In evaluating BCG vaccination, one must first define its potentialities. BCG vaccine, properly administered, will increase the resistance of both animal and man to virulent tubercle bacilli. This resistance is not absolute. The degree of resistance that it is possible to develop against tuberculosis may not be as great as for some other disease. Yet it should be borne in mind that there is no disease against which absolute immunity can be achieved. This fact was sharply brought into focus with the report of an epidemic of smallpox among our armed forces in Korea.1 This experience showed that adequate exposure could break down resistance even after multiple vaccinations against smallpox. The potency of the vaccine and the methods of administration were also taken into consideration. In evaluating BCG vaccination, all of these factors must be considered: (1) the vaccine itself, (2) the method of administration, and (3) the degree

Journal

JAMA – American Medical Association

Published: Mar 5, 1955

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