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Staging for Intrahepatic Cholangiocarcinoma

Staging for Intrahepatic Cholangiocarcinoma Staging for Intrahepatic Cholangiocarcinoma Invited Commentary Invited Commentary Are We Getting Close to Understanding the True Tumor Biology? Koji Tomiyama, MD; Roberto Hernandez-Alejandro, MD; David C. Linehan, MD The worldwide incidence of intrahepatic cholangiocar- Despite previous evidence of margin status as a prognos- cinoma (ICC) is increasing, and the oncological outcomes are tic factor for ICC, it was not included in this proposal. Unfortu- far from satisfactory. Lack of both an understanding of its tu- nately, lymph node status was also not fully evaluated because mor biology and a distinct staging system that gives us accu- only 44% of the included patients had a lymphadenectomy. In- rate prognostic value could be stead, the authors identified 2 new factors as negative predic- the reason for this disappoint- tors, older age and poor tumor differentiation, that were not al- Related article ing outcome. Therefore, there ways incorporated in previously reported staging systems. The is a need to develop a solid authors present evidence that their new prognostic score pro- staging system that provides integrated guidance for the treat- vides better stage-based outcome discrimination compared with ment of ICC. Historically, the hepatocellular carcinoma stag- AJCC Seventh Edition on the validation analysis using http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Surgery American Medical Association

Staging for Intrahepatic Cholangiocarcinoma

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Staging for Intrahepatic Cholangiocarcinoma

Abstract

Staging for Intrahepatic Cholangiocarcinoma Invited Commentary Invited Commentary Are We Getting Close to Understanding the True Tumor Biology? Koji Tomiyama, MD; Roberto Hernandez-Alejandro, MD; David C. Linehan, MD The worldwide incidence of intrahepatic cholangiocar- Despite previous evidence of margin status as a prognos- cinoma (ICC) is increasing, and the oncological outcomes are tic factor for ICC, it was not included in this proposal. Unfortu- far from satisfactory. Lack of both an...
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Publisher
American Medical Association
Copyright
Copyright 2017 American Medical Association. All Rights Reserved.
ISSN
2168-6254
eISSN
2168-6262
DOI
10.1001/jamasurg.2017.0108
Publisher site
See Article on Publisher Site

Abstract

Staging for Intrahepatic Cholangiocarcinoma Invited Commentary Invited Commentary Are We Getting Close to Understanding the True Tumor Biology? Koji Tomiyama, MD; Roberto Hernandez-Alejandro, MD; David C. Linehan, MD The worldwide incidence of intrahepatic cholangiocar- Despite previous evidence of margin status as a prognos- cinoma (ICC) is increasing, and the oncological outcomes are tic factor for ICC, it was not included in this proposal. Unfortu- far from satisfactory. Lack of both an understanding of its tu- nately, lymph node status was also not fully evaluated because mor biology and a distinct staging system that gives us accu- only 44% of the included patients had a lymphadenectomy. In- rate prognostic value could be stead, the authors identified 2 new factors as negative predic- the reason for this disappoint- tors, older age and poor tumor differentiation, that were not al- Related article ing outcome. Therefore, there ways incorporated in previously reported staging systems. The is a need to develop a solid authors present evidence that their new prognostic score pro- staging system that provides integrated guidance for the treat- vides better stage-based outcome discrimination compared with ment of ICC. Historically, the hepatocellular carcinoma stag- AJCC Seventh Edition on the validation analysis using

Journal

JAMA Surgery – American Medical Association

Published: May 15, 2017

References

  • AJCC 7th edition of TNM staging accurately discriminates outcomes of patients with resectable intrahepatic cholangiocarcinoma: by the AFC-IHCC-2009 study group
    Farges, O; Fuks, D; Le Treut, YP
  • Proposal of a new staging system for intrahepatic cholangiocarcinoma: analysis of surgical patients from a nationwide survey of the Liver Cancer Study Group of Japan
    Sakamoto, Y; Kokudo, N; Matsuyama, Y
  • Outcomes after resection of intrahepatic cholangiocarcinoma: external validation and comparison of prognostic models
    Doussot, A; Groot-Koerkamp, B; Wiggers, JK
  • A nomogram to predict long-term survival after resection for intrahepatic cholangiocarcinoma: an Eastern and Western experience
    Hyder, O; Marques, H; Pulitano, C
  • Prognostic nomogram for intrahepatic cholangiocarcinoma after partial hepatectomy
    Wang, Y; Li, J; Xia, Y
  • A prognostic scoring system based on clinical features of intrahepatic cholangiocarcinoma: the Fudan score
    Jiang, W; Zeng, ZC; Tang, ZY
  • Development and validation of a prognostic score for intrahepatic cholangiocarcinoma [published online March 15, 2017]
    Raoof, M; Dumitra, S; Ituarte, PHG
  • Treatment and prognosis for patients with intrahepatic cholangiocarcinoma: systematic review and meta-analysis
    Mavros, MN; Economopoulos, KP; Alexiou, VG; Pawlik, TM

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