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Staging for Intrahepatic Cholangiocarcinoma

Staging for Intrahepatic Cholangiocarcinoma Staging for Intrahepatic Cholangiocarcinoma Invited Commentary Invited Commentary Are We Getting Close to Understanding the True Tumor Biology? Koji Tomiyama, MD; Roberto Hernandez-Alejandro, MD; David C. Linehan, MD The worldwide incidence of intrahepatic cholangiocar- Despite previous evidence of margin status as a prognos- cinoma (ICC) is increasing, and the oncological outcomes are tic factor for ICC, it was not included in this proposal. Unfortu- far from satisfactory. Lack of both an understanding of its tu- nately, lymph node status was also not fully evaluated because mor biology and a distinct staging system that gives us accu- only 44% of the included patients had a lymphadenectomy. In- rate prognostic value could be stead, the authors identified 2 new factors as negative predic- the reason for this disappoint- tors, older age and poor tumor differentiation, that were not al- Related article ing outcome. Therefore, there ways incorporated in previously reported staging systems. The is a need to develop a solid authors present evidence that their new prognostic score pro- staging system that provides integrated guidance for the treat- vides better stage-based outcome discrimination compared with ment of ICC. Historically, the hepatocellular carcinoma stag- AJCC Seventh Edition on the validation analysis using http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Surgery American Medical Association

Staging for Intrahepatic Cholangiocarcinoma

Staging for Intrahepatic Cholangiocarcinoma

Abstract

Staging for Intrahepatic Cholangiocarcinoma Invited Commentary Invited Commentary Are We Getting Close to Understanding the True Tumor Biology? Koji Tomiyama, MD; Roberto Hernandez-Alejandro, MD; David C. Linehan, MD The worldwide incidence of intrahepatic cholangiocar- Despite previous evidence of margin status as a prognos- cinoma (ICC) is increasing, and the oncological outcomes are tic factor for ICC, it was not included in this proposal. Unfortu- far from satisfactory. Lack of both an...
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Publisher
American Medical Association
Copyright
Copyright 2017 American Medical Association. All Rights Reserved.
ISSN
2168-6254
eISSN
2168-6262
DOI
10.1001/jamasurg.2017.0108
Publisher site
See Article on Publisher Site

Abstract

Staging for Intrahepatic Cholangiocarcinoma Invited Commentary Invited Commentary Are We Getting Close to Understanding the True Tumor Biology? Koji Tomiyama, MD; Roberto Hernandez-Alejandro, MD; David C. Linehan, MD The worldwide incidence of intrahepatic cholangiocar- Despite previous evidence of margin status as a prognos- cinoma (ICC) is increasing, and the oncological outcomes are tic factor for ICC, it was not included in this proposal. Unfortu- far from satisfactory. Lack of both an understanding of its tu- nately, lymph node status was also not fully evaluated because mor biology and a distinct staging system that gives us accu- only 44% of the included patients had a lymphadenectomy. In- rate prognostic value could be stead, the authors identified 2 new factors as negative predic- the reason for this disappoint- tors, older age and poor tumor differentiation, that were not al- Related article ing outcome. Therefore, there ways incorporated in previously reported staging systems. The is a need to develop a solid authors present evidence that their new prognostic score pro- staging system that provides integrated guidance for the treat- vides better stage-based outcome discrimination compared with ment of ICC. Historically, the hepatocellular carcinoma stag- AJCC Seventh Edition on the validation analysis using

Journal

JAMA SurgeryAmerican Medical Association

Published: May 15, 2017

References

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