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Spontaneous Closure of Small Ventricular Septal Defects: Probability Rates in the First Five Years of Life

Spontaneous Closure of Small Ventricular Septal Defects: Probability Rates in the First Five... Abstract Infants with a clinical diagnosis of small ventricular septal defect made between 1967 and 1969 have been reviewed; recent physical examination data was obtained for 52 of the 55 children. Spontaneous closure of the ventricular defect occurred in 30 patients (58%). The incidence of closure was considered separately for muscular (65%) and membranous defects (25%), as well as for those defects where the anatomic position could not be determined clinically (58%). Age at closure, duration and intensity of the murmur, and the number of months of follow-up in nonclosures were all analyzed. As a practical index, the probabilities of closure by 5 years of age were calculated for patients theoretically presenting at birth, 1 year, and 2 years of age. These were, respectively, 58%, 48%, and 35%. References 1. Carlgren LE: The third Edgar Mannheimer memorial lecture: The incidence of congenital heart disease in Gothenburg . Proc Assoc Europ Paediatr Cardiol 5:2-8, 1969. 2. Evans JR, Rowe RD, Keith JD: Spontaneous closure of ventricular septal defects . Circulation 22:1044-1054, 1960.Crossref 3. Hoffman J, Rudolph A: The natural history of ventricular septal defects in infancy . Am J Cardiol 16:634-653, 1965.Crossref 4. Pieroni DR, et al: Auscultatory recognition of aneurysm of the membranous ventricular septum associated with small ventricular septal defect . Circulation 44:733-739, 1971.Crossref 5. Varghese PJ, et al: Aneurysm of the membranous ventricular septum . Am J Cardiol 24:531-536, 1969.Crossref 6. Varghese PJ, Rowe RD: Spontaneous closure of ventricular septal defects by aneurysmal formation of the membranous septum . J Pediat 75:700-703, 1969.Crossref 7. Li MD, et al: Spontaneous closure of ventricular septal defect . Can Med Assoc J 100:737-743, 1969. 8. Hoffman JE: Natural history of congenital heart disease: Problems in its assessment with special reference to ventricular septal defects . Circulation 37:97-125, 1968.Crossref 9. Li MD, Keith JD: Spontaneous closure of ventricular septal defect . Am Heart J 80:432-433, 1970.Crossref 10. Mitchell SC, et al: Congenital heart disease in 56,109 births: Incidence and natural history . Circulation 43:323-332, 1971.Crossref 11. Nadas AS, et al: Spontaneous functional closing of ventricular septal defects . N Engl J Med 264:309-316, 1961.Crossref 12. Wade G, Wright J: Spontaneous closure of ventricular septal defects . Lancet 1:737-740, 1963.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Spontaneous Closure of Small Ventricular Septal Defects: Probability Rates in the First Five Years of Life

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References (12)

Publisher
American Medical Association
Copyright
Copyright © 1973 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1973.04160020028005
Publisher site
See Article on Publisher Site

Abstract

Abstract Infants with a clinical diagnosis of small ventricular septal defect made between 1967 and 1969 have been reviewed; recent physical examination data was obtained for 52 of the 55 children. Spontaneous closure of the ventricular defect occurred in 30 patients (58%). The incidence of closure was considered separately for muscular (65%) and membranous defects (25%), as well as for those defects where the anatomic position could not be determined clinically (58%). Age at closure, duration and intensity of the murmur, and the number of months of follow-up in nonclosures were all analyzed. As a practical index, the probabilities of closure by 5 years of age were calculated for patients theoretically presenting at birth, 1 year, and 2 years of age. These were, respectively, 58%, 48%, and 35%. References 1. Carlgren LE: The third Edgar Mannheimer memorial lecture: The incidence of congenital heart disease in Gothenburg . Proc Assoc Europ Paediatr Cardiol 5:2-8, 1969. 2. Evans JR, Rowe RD, Keith JD: Spontaneous closure of ventricular septal defects . Circulation 22:1044-1054, 1960.Crossref 3. Hoffman J, Rudolph A: The natural history of ventricular septal defects in infancy . Am J Cardiol 16:634-653, 1965.Crossref 4. Pieroni DR, et al: Auscultatory recognition of aneurysm of the membranous ventricular septum associated with small ventricular septal defect . Circulation 44:733-739, 1971.Crossref 5. Varghese PJ, et al: Aneurysm of the membranous ventricular septum . Am J Cardiol 24:531-536, 1969.Crossref 6. Varghese PJ, Rowe RD: Spontaneous closure of ventricular septal defects by aneurysmal formation of the membranous septum . J Pediat 75:700-703, 1969.Crossref 7. Li MD, et al: Spontaneous closure of ventricular septal defect . Can Med Assoc J 100:737-743, 1969. 8. Hoffman JE: Natural history of congenital heart disease: Problems in its assessment with special reference to ventricular septal defects . Circulation 37:97-125, 1968.Crossref 9. Li MD, Keith JD: Spontaneous closure of ventricular septal defect . Am Heart J 80:432-433, 1970.Crossref 10. Mitchell SC, et al: Congenital heart disease in 56,109 births: Incidence and natural history . Circulation 43:323-332, 1971.Crossref 11. Nadas AS, et al: Spontaneous functional closing of ventricular septal defects . N Engl J Med 264:309-316, 1961.Crossref 12. Wade G, Wright J: Spontaneous closure of ventricular septal defects . Lancet 1:737-740, 1963.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Feb 1, 1973

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