Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Spontaneous Canine Keratoconjunctivitis Sicca: A Useful Model for Human Keratoconjunctivitis Sicca: Treatment With Cyclosporine Eye Drops

Spontaneous Canine Keratoconjunctivitis Sicca: A Useful Model for Human Keratoconjunctivitis... Abstract • Thirty-six sequential cases of canine keratoconjunctivitis sicca (KCS) were treated with ophthalmic cyclosporine. The effects of topical cyclosporine were twofold: (1) cyclosporine increased tear production by 5 mm/min or greater in all cases of spontaneous KCS having an initial Schirmer's Tear Test value greater than 2 mm /min and in 59% of eyes with an initial Schirmer's Tear Test value of 0 to 2 mm/min, and (2) cyclosporine caused marked regression of chronic corneal neovascularization and granulation even in eyes in which lacrimation failed to improve. Additional benefits of topical cyclosporine were reduced mucopurulent conjunctivitis, rapid healing of nonhealing corneal ulcers, and reduced dependence on frequent topical treatments of KCS. Twelve normal beagles treated with topical cyclosporine also had a reversible increase in lacrimation compared with baseline or placebo control-treated dogs. References 1. Kaswan RL, Martin CL, Chapman WL. Keratoconjunctivitis sicca: histopathologic study of nictitating membrane and lacrimal glands from 28 canine cases . Am J Vet Res . 1984;45:112-118. 2. Kaswan RL, Martin CL, Dawe DL. Rheumatoid factor determination in 50 dogs with keratoconjunctivitis sicca . J Am Vet Med Assoc . 1983;183:1073-1075. 3. Kaswan RL, Martin CL, Dawe DL. Keratoconjunctivitis sicca: immunological evaluation of 62 canine cases . Am J Vet Res . 1985;46:376-383. 4. Quimby FW, Schwartz RS, Poskitt T, Lewis RM. A disorder of dogs resembling Sjögren's syndrome . Clin Immunol Immunopathol . 1979;12:471-476.Crossref 5. Hoffman RW, Walker S. Animal models of Sjögren's syndrome . In: Talal N, ed. Sjögren's Syndrome . New York, NY: Springer-Verlag NY Inc; 1987:226-290. 6. Pflugfelder SC, Wilhelmus KR, Osato MS. The autoimmune nature of aqueous tear deficiency . Ophthalmology . 1986;93:1513-1517.Crossref 7. Wieczorek R, Jakobiec FA, Sacks EH, Knowles DM. The immunoarchitecture of the normal human lacrimal gland: relevancy for understanding pathologic conditions . Ophthalmology . 1988;95:100-109.Crossref 8. Jabs DA, Prendergast RA. Ocular autoimmunity in MRL/Mp-Ipr/Ipr mice . Proc Int Soc Eye Res . 1988;29:1437-1443. 9. Jabs, DA, Prendergrast RA. Reactive lymphocytes in lacrimal gland and vasculitic renal lesions of autoimmune MRL/Ipr mice express L3T4 . J Exp Med . 1987;166:1198-1203.Crossref 10. Kaswan RL, Salisbury MA, Ward DL. Topical application of cyclosporine in the management of keratoconjunctivitis sicca in dogs. J Am Anim Hosp Assoc. In press. 11. Leuenberger PM, Miescher PA. Syndrome de Sjögren: traitement par la ciclosporine: communication preliminaire . Klin Monatsbl Augenheilkd . 1987;190:290-292.Crossref 12. Drosos AA, Skopouli FN, Costopoulos JS, Papadimitriou CS, Moutsopoulos HM. Cyclosporin A (Cy A) in primary Sjögren's syndrome: a double blind study . Ann Rheum Dis . 1986;45:732-735.Crossref 13. Dalavanga YA, Detrick B, Hooks JJ, Drosos AA, Moutsopoulos HM. Effect of cyclosporin A (Cy A) on the immunopathological lesion of the labial minor salivary glands from patients with Sjögren's syndrome . Ann Rheum Dis . 1987;46:89-92.Crossref 14. Holloway M. A teary saga of dry eye, cyclosporine . Med Tribune . 1988;29:14. 15. Kaswan RL. Intraocular penetration of topically applied cyclosporine . Transplant Proc . 1988;209:650-655. 16. Ray WA, O'Day DM, Head WS, Robinson R. Statistical analysis for experimental models of ocular disease: continuous response measures . Curr Eye Res . 1985;4:585-597.Crossref 17. Martin CL, Kaswan RL. Distemper-associated keratoconjunctivitis sicca . J Am Anim Hosp Assoc . 1985;21:355-359. 18. Aquirre GD, Rubin LF, Harvey CE. Keratoconjunctivitis sicca in dogs . J Am Vet Med Assoc . 1971;158:1566-1579. 19. Moore CP, Collier LL. Mucin deficient external eye disease in dogs . Trans Am Coll Vet Ophthalmol . 1985;16:152-167. 20. Carrington SD, Bedford PGC, Guillon JP, Woodward EG. Polarized light biomicroscopic observations on the pre-corneal tear film, II: keratoconjunctivitis sicca in the dog . J Small Anim Pract . 1987;28:671-679.Crossref 21. Roberts SR, Erickson OF. Dog tear secretion and tear proteins . J Small Anim Pract . 1962;3:1-5.Crossref 22. Kaswan RL, Fischer CA, Ward DA, Martin C, Ramsey J. Clinical trials of ophthalmic cyclosporine in chronic keratitis . Trans Am Coll Vet Ophthalmol . 1987;18:276-295. 23. Hoffman RW, Alspaugh MA, Waggie KS, Durham JB, Walker SE. Sjögren's syndrome in MRL/1 and MRL/n mice . Arthritis Rheum . 1984;27:157-165.Crossref 24. Gilbard JP, Hanninen LA, Rothman RC, Kenyon KR. Lacrimal gland, cornea, and tear film in the NZB/NZW F, hybrid mouse . Curr Eye Res . 1987;6:1237-1248.Crossref 25. Williamson J, Gibson AAM, Wilson T, Forrester JV. Histology of the lacrimal gland in keratoconjunctivitis sicca . Br J Ophthalmol . 1973;57:852-858.Crossref 26. Bachrach A, Scagliotti R. Topical cyclosporine for KCS . Adv SAM . 1988;1:1-2. 27. Gudmundsson OG, Benediktsson H, Olafsdottir K. T-lymphocyte subsets in the human lacrimal gland . Acta Ophthalmol (Copenh) . 1988;66:19-23.Crossref 28. Hodgkin PD, Hapel AJ, Johnson RM, Young IG, Lafferty KJ. Blocking of delivery of the antigen mediated signal to the nucleus of T-cells by cyclosporine . Transplantation . 1987;43:685-691.Crossref 29. Kaswan RL, Kaplan HJ. Comparison of the efficacy of unilateral, bilateral, and oral cyclosporine in experimental immunogenic uveitis in rabbits . Trans Proc . 1988;20( (suppl 4) ):149-157. 30. Koletsky AJ, Harding MW, Handshumacker RE. Cyclophilin: distribution and variant properties in normal and neoplastic tissues . J Immunol . 1986;137:1054-1059. 31. Russell DH, Kibler R, Martrisian L, Larson DF, Poulos B. Prolactin receptors on human T and B lymphocytes: antagonism of prolactin binding by cyclosporine . J Immunol . 1985;134:3027-3031. 32. Frey WH, Nelson JD, Frick ML, Elde RP. Prolactin immunoreactivity human tears and lacrimal gland: possible implications for tear production . In: Holly FJ, ed. The Preocular Tear Film in Health, Disease and Contact Lens Wear . Lubbock, Tex: Dry Eye Institute; 1986:798-807. 33. Sullivan DA. Hormonal modulation of tear volume in the rat . Exp Eye Res . 1986;42:131-139.Crossref 34. Furue M, Gospori AA, Katz SI. The effect of cyclosporin A inhibits proliferation of normal and transformed keratinocytes . J Invest Dermatol . 1988;90:796-800.Crossref 35. Nickoloff BJ, Fisher GJ, Mitra RS, Voorhees JJ. Direct cytopathic effects of cyclosporine A on rapidly proliferating cultured keratinocytes and dermal fibroblasts . Trans Proc . 1988;20:85-90. 36. Nickoloff B, Fisher GJ, Mitra RS. Additive and synergistic antiproliferative effects of cyclosporin A and gamma interferon on cultured human keratinocytes . Am J Pathol . 1988;131:12-18. 37. Kossendrup D, Wiederholt M, Hoffman F. Influence of cyclosporin A, dexamethasone and benzalkonium chloride on corneal epithelial wound healing in the rabbit and guinea pig eye . Cornea . 1986;4:177-181. 38. Nussenblatt RB, Dinning WJ, Fujikawa LS, Chan C-C, Palestine AG. Local cyclosporine therapy for experimental autoimmune uveitis in rats . Arch Ophthalmol . 1985;103:1559-1562.Crossref 39. Woods AC. Clinical and experimental observation on the use of ACTH and cortisone in ocular inflammatory disease . Am J Ophthalmol . 1950;33:1325-1349. 40. Foets B, Missotten L, Vanderveeren P, Goossens W. Prolonged survival of allogenic corneal grafts in rabbits treated with topically applied cyclosporin A: systemic absorption and local immunosuppressive effect . Br J Ophthalmol . 1985;69:600-603.Crossref 41. Goichot-Bonnat L, DeBeauregard C, Saragoussi JJ, Pouliquen Y. Usage de la cyclosporine A collyre dans la prevention du reject de greffe de cornee chezl'homme . J Fr Ophthalmol . 1987;10:207-211. 42. Goichot-Bonnat L, Chemla P, Pouliquen Y. Cyclosporine A collyre dans la prevention du reject de greffe de cornee a haut risque, II: resultats cliniques post-operatoires . J Fr Ophthalmol . 1987;10:213-217. 43. Hoffman F, Wiederholt M. Topical cyclosporin A in the treatment of corneal graft reaction . Cornea . 1986;5:129.Crossref 44. Hoffman F, Wiederholt M. Local treatment of necrotizing scleritis with cyclosporin A . Cornea . 1985;4:3-7.Crossref 45. BenEzra D, Pe'er J, Brodsky M, Cohen E. Cyclosporine eyedrops for the treatment of severe vernal keratoconjunctivitis . Am J Ophthalmol . 1986;101:278-282. 46. Aldridge RD, Sewell HF, King G, Thomson AW. Topical cyclosporin A in nickel contact hypersensitivity: results of a preliminary clinical and immunohistochemical investigation . Clin Exp Immunol . 1986;66:582-584. 47. Halliday GM, Knight BA, Muller HK. Reduction in murine Langerhans cell ATPase staining following topical but not systemic treatment with steroid and nonsteroid immunosuppressants . Br J Dermatol . 1986;114:83.Crossref 48. Lai CS, Wesseler TA, Alex JW, Babcock GF. Long term survival of skin allografts in rats treated with topical cyclosporine . Trans Proc . 1987;44:83. 49. Tabbara KF, Frayha RA. Alternate day steroid therapy for patients with Sjögren's syndrome . Ann Ophthalmol . 1983;15:358-361. 50. Lemp MA. Recent developments in dry eye management . Ophthalmology . 1987;94:1299-1304.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Spontaneous Canine Keratoconjunctivitis Sicca: A Useful Model for Human Keratoconjunctivitis Sicca: Treatment With Cyclosporine Eye Drops

Loading next page...
 
/lp/american-medical-association/spontaneous-canine-keratoconjunctivitis-sicca-a-useful-model-for-human-iG3BJ3vrgb
Publisher
American Medical Association
Copyright
Copyright © 1989 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1989.01070020276038
Publisher site
See Article on Publisher Site

Abstract

Abstract • Thirty-six sequential cases of canine keratoconjunctivitis sicca (KCS) were treated with ophthalmic cyclosporine. The effects of topical cyclosporine were twofold: (1) cyclosporine increased tear production by 5 mm/min or greater in all cases of spontaneous KCS having an initial Schirmer's Tear Test value greater than 2 mm /min and in 59% of eyes with an initial Schirmer's Tear Test value of 0 to 2 mm/min, and (2) cyclosporine caused marked regression of chronic corneal neovascularization and granulation even in eyes in which lacrimation failed to improve. Additional benefits of topical cyclosporine were reduced mucopurulent conjunctivitis, rapid healing of nonhealing corneal ulcers, and reduced dependence on frequent topical treatments of KCS. Twelve normal beagles treated with topical cyclosporine also had a reversible increase in lacrimation compared with baseline or placebo control-treated dogs. References 1. Kaswan RL, Martin CL, Chapman WL. Keratoconjunctivitis sicca: histopathologic study of nictitating membrane and lacrimal glands from 28 canine cases . Am J Vet Res . 1984;45:112-118. 2. Kaswan RL, Martin CL, Dawe DL. Rheumatoid factor determination in 50 dogs with keratoconjunctivitis sicca . J Am Vet Med Assoc . 1983;183:1073-1075. 3. Kaswan RL, Martin CL, Dawe DL. Keratoconjunctivitis sicca: immunological evaluation of 62 canine cases . Am J Vet Res . 1985;46:376-383. 4. Quimby FW, Schwartz RS, Poskitt T, Lewis RM. A disorder of dogs resembling Sjögren's syndrome . Clin Immunol Immunopathol . 1979;12:471-476.Crossref 5. Hoffman RW, Walker S. Animal models of Sjögren's syndrome . In: Talal N, ed. Sjögren's Syndrome . New York, NY: Springer-Verlag NY Inc; 1987:226-290. 6. Pflugfelder SC, Wilhelmus KR, Osato MS. The autoimmune nature of aqueous tear deficiency . Ophthalmology . 1986;93:1513-1517.Crossref 7. Wieczorek R, Jakobiec FA, Sacks EH, Knowles DM. The immunoarchitecture of the normal human lacrimal gland: relevancy for understanding pathologic conditions . Ophthalmology . 1988;95:100-109.Crossref 8. Jabs DA, Prendergast RA. Ocular autoimmunity in MRL/Mp-Ipr/Ipr mice . Proc Int Soc Eye Res . 1988;29:1437-1443. 9. Jabs, DA, Prendergrast RA. Reactive lymphocytes in lacrimal gland and vasculitic renal lesions of autoimmune MRL/Ipr mice express L3T4 . J Exp Med . 1987;166:1198-1203.Crossref 10. Kaswan RL, Salisbury MA, Ward DL. Topical application of cyclosporine in the management of keratoconjunctivitis sicca in dogs. J Am Anim Hosp Assoc. In press. 11. Leuenberger PM, Miescher PA. Syndrome de Sjögren: traitement par la ciclosporine: communication preliminaire . Klin Monatsbl Augenheilkd . 1987;190:290-292.Crossref 12. Drosos AA, Skopouli FN, Costopoulos JS, Papadimitriou CS, Moutsopoulos HM. Cyclosporin A (Cy A) in primary Sjögren's syndrome: a double blind study . Ann Rheum Dis . 1986;45:732-735.Crossref 13. Dalavanga YA, Detrick B, Hooks JJ, Drosos AA, Moutsopoulos HM. Effect of cyclosporin A (Cy A) on the immunopathological lesion of the labial minor salivary glands from patients with Sjögren's syndrome . Ann Rheum Dis . 1987;46:89-92.Crossref 14. Holloway M. A teary saga of dry eye, cyclosporine . Med Tribune . 1988;29:14. 15. Kaswan RL. Intraocular penetration of topically applied cyclosporine . Transplant Proc . 1988;209:650-655. 16. Ray WA, O'Day DM, Head WS, Robinson R. Statistical analysis for experimental models of ocular disease: continuous response measures . Curr Eye Res . 1985;4:585-597.Crossref 17. Martin CL, Kaswan RL. Distemper-associated keratoconjunctivitis sicca . J Am Anim Hosp Assoc . 1985;21:355-359. 18. Aquirre GD, Rubin LF, Harvey CE. Keratoconjunctivitis sicca in dogs . J Am Vet Med Assoc . 1971;158:1566-1579. 19. Moore CP, Collier LL. Mucin deficient external eye disease in dogs . Trans Am Coll Vet Ophthalmol . 1985;16:152-167. 20. Carrington SD, Bedford PGC, Guillon JP, Woodward EG. Polarized light biomicroscopic observations on the pre-corneal tear film, II: keratoconjunctivitis sicca in the dog . J Small Anim Pract . 1987;28:671-679.Crossref 21. Roberts SR, Erickson OF. Dog tear secretion and tear proteins . J Small Anim Pract . 1962;3:1-5.Crossref 22. Kaswan RL, Fischer CA, Ward DA, Martin C, Ramsey J. Clinical trials of ophthalmic cyclosporine in chronic keratitis . Trans Am Coll Vet Ophthalmol . 1987;18:276-295. 23. Hoffman RW, Alspaugh MA, Waggie KS, Durham JB, Walker SE. Sjögren's syndrome in MRL/1 and MRL/n mice . Arthritis Rheum . 1984;27:157-165.Crossref 24. Gilbard JP, Hanninen LA, Rothman RC, Kenyon KR. Lacrimal gland, cornea, and tear film in the NZB/NZW F, hybrid mouse . Curr Eye Res . 1987;6:1237-1248.Crossref 25. Williamson J, Gibson AAM, Wilson T, Forrester JV. Histology of the lacrimal gland in keratoconjunctivitis sicca . Br J Ophthalmol . 1973;57:852-858.Crossref 26. Bachrach A, Scagliotti R. Topical cyclosporine for KCS . Adv SAM . 1988;1:1-2. 27. Gudmundsson OG, Benediktsson H, Olafsdottir K. T-lymphocyte subsets in the human lacrimal gland . Acta Ophthalmol (Copenh) . 1988;66:19-23.Crossref 28. Hodgkin PD, Hapel AJ, Johnson RM, Young IG, Lafferty KJ. Blocking of delivery of the antigen mediated signal to the nucleus of T-cells by cyclosporine . Transplantation . 1987;43:685-691.Crossref 29. Kaswan RL, Kaplan HJ. Comparison of the efficacy of unilateral, bilateral, and oral cyclosporine in experimental immunogenic uveitis in rabbits . Trans Proc . 1988;20( (suppl 4) ):149-157. 30. Koletsky AJ, Harding MW, Handshumacker RE. Cyclophilin: distribution and variant properties in normal and neoplastic tissues . J Immunol . 1986;137:1054-1059. 31. Russell DH, Kibler R, Martrisian L, Larson DF, Poulos B. Prolactin receptors on human T and B lymphocytes: antagonism of prolactin binding by cyclosporine . J Immunol . 1985;134:3027-3031. 32. Frey WH, Nelson JD, Frick ML, Elde RP. Prolactin immunoreactivity human tears and lacrimal gland: possible implications for tear production . In: Holly FJ, ed. The Preocular Tear Film in Health, Disease and Contact Lens Wear . Lubbock, Tex: Dry Eye Institute; 1986:798-807. 33. Sullivan DA. Hormonal modulation of tear volume in the rat . Exp Eye Res . 1986;42:131-139.Crossref 34. Furue M, Gospori AA, Katz SI. The effect of cyclosporin A inhibits proliferation of normal and transformed keratinocytes . J Invest Dermatol . 1988;90:796-800.Crossref 35. Nickoloff BJ, Fisher GJ, Mitra RS, Voorhees JJ. Direct cytopathic effects of cyclosporine A on rapidly proliferating cultured keratinocytes and dermal fibroblasts . Trans Proc . 1988;20:85-90. 36. Nickoloff B, Fisher GJ, Mitra RS. Additive and synergistic antiproliferative effects of cyclosporin A and gamma interferon on cultured human keratinocytes . Am J Pathol . 1988;131:12-18. 37. Kossendrup D, Wiederholt M, Hoffman F. Influence of cyclosporin A, dexamethasone and benzalkonium chloride on corneal epithelial wound healing in the rabbit and guinea pig eye . Cornea . 1986;4:177-181. 38. Nussenblatt RB, Dinning WJ, Fujikawa LS, Chan C-C, Palestine AG. Local cyclosporine therapy for experimental autoimmune uveitis in rats . Arch Ophthalmol . 1985;103:1559-1562.Crossref 39. Woods AC. Clinical and experimental observation on the use of ACTH and cortisone in ocular inflammatory disease . Am J Ophthalmol . 1950;33:1325-1349. 40. Foets B, Missotten L, Vanderveeren P, Goossens W. Prolonged survival of allogenic corneal grafts in rabbits treated with topically applied cyclosporin A: systemic absorption and local immunosuppressive effect . Br J Ophthalmol . 1985;69:600-603.Crossref 41. Goichot-Bonnat L, DeBeauregard C, Saragoussi JJ, Pouliquen Y. Usage de la cyclosporine A collyre dans la prevention du reject de greffe de cornee chezl'homme . J Fr Ophthalmol . 1987;10:207-211. 42. Goichot-Bonnat L, Chemla P, Pouliquen Y. Cyclosporine A collyre dans la prevention du reject de greffe de cornee a haut risque, II: resultats cliniques post-operatoires . J Fr Ophthalmol . 1987;10:213-217. 43. Hoffman F, Wiederholt M. Topical cyclosporin A in the treatment of corneal graft reaction . Cornea . 1986;5:129.Crossref 44. Hoffman F, Wiederholt M. Local treatment of necrotizing scleritis with cyclosporin A . Cornea . 1985;4:3-7.Crossref 45. BenEzra D, Pe'er J, Brodsky M, Cohen E. Cyclosporine eyedrops for the treatment of severe vernal keratoconjunctivitis . Am J Ophthalmol . 1986;101:278-282. 46. Aldridge RD, Sewell HF, King G, Thomson AW. Topical cyclosporin A in nickel contact hypersensitivity: results of a preliminary clinical and immunohistochemical investigation . Clin Exp Immunol . 1986;66:582-584. 47. Halliday GM, Knight BA, Muller HK. Reduction in murine Langerhans cell ATPase staining following topical but not systemic treatment with steroid and nonsteroid immunosuppressants . Br J Dermatol . 1986;114:83.Crossref 48. Lai CS, Wesseler TA, Alex JW, Babcock GF. Long term survival of skin allografts in rats treated with topical cyclosporine . Trans Proc . 1987;44:83. 49. Tabbara KF, Frayha RA. Alternate day steroid therapy for patients with Sjögren's syndrome . Ann Ophthalmol . 1983;15:358-361. 50. Lemp MA. Recent developments in dry eye management . Ophthalmology . 1987;94:1299-1304.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Aug 1, 1989

References