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Spontaneous Atrophic Patches in Extremely Premature Infants: Anetoderma of Prematurity

Spontaneous Atrophic Patches in Extremely Premature Infants: Anetoderma of Prematurity Abstract Background: Anetoderma, characterized clinically by macular depressions or outpouchings of skin, is associated with loss of dermal elastic tissue as noted on histopathologic findings. We report on 9 extremely premature infants who developed patches of anetoderma during their course in the neonatal intensive care unit. Observations: All 9 patients were born between the ages of 24 and 29 weeks of gestation and had numerous complications associated with prematurity. Eight of the 9 infants were noted to have developed anetoderma on the trunk and proximal extremities while in the neonatal intensive care unit. The locations of the lesions on the skin were not explained by previous trauma, although many areas corresponded with placement of monitoring leads or with adhesive for a monitoring device. Reduction or absence of elastic tissue supported the diagnosis of anetoderma in 4 of 5 biopsy specimens. Conclusion: We report a previously unrecognized type of anetoderma associated with extreme prematurity. The exact cause is uncertain, although reactions to cutaneous monitoring leads or adhesives is suspected.(Arch Dermatol. 1996;132:671-674) References 1. Venencie PY, Winkelmann RK, Moore BA. Anetoderma . Arch Dermatol. 1984; 120:1032-1039.Crossref 2. Misch KJ, Rhodes EL, Allen J, Kersey P. Anetoderma of Jadassohn . J R Soc Med. 1988;81:734-736. 3. Schweninger E, Buzzi F. Multiple benign tumor-like new growths on the skin . In: Unna PG, Morris M, Besner E, et al, eds. International Atlas of Rare Skin Diseases . Hamburg, Germany: Leopold Voss; 1889-1899;5(chap 15, pt (1) ):4-5. 4. Jadassohn J. Ueber eine eigenartige Form von 'Atrophia Maculosa Cutis.' Arch Dermatol Syphilol. 1892;( (suppl 1) ):342-358. 5. Pellizari C. Eritema orticato atrofizzante: atrofia parziale idiopatica della pelle . G Ital Mal Ven 1884;19:230-243. 6. Venencie PY, Winkelman RK. Histopathologic findings in anetoderma . Arch Dermatol. 1984;120:1040-1044.Crossref 7. Muster AJ, Bharati S, Herman JJ, et al. Fatal cardiovascular disease and cutis laxa following acute febrile neutrophilic dermatosis . J Pediatr. 1983;102:243-248.Crossref 8. Golden SM. Skin craters: a complication of transcutaneous oxygen monitoring . Pediatrics. 1981;67:514-516. 9. Cartridge PHT, Fox PE, Rutter N. The scars of newborn intensive care . Early Hum Dev. 1990;21:1-10.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Spontaneous Atrophic Patches in Extremely Premature Infants: Anetoderma of Prematurity

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Publisher
American Medical Association
Copyright
Copyright © 1996 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1996.03890300095013
Publisher site
See Article on Publisher Site

Abstract

Abstract Background: Anetoderma, characterized clinically by macular depressions or outpouchings of skin, is associated with loss of dermal elastic tissue as noted on histopathologic findings. We report on 9 extremely premature infants who developed patches of anetoderma during their course in the neonatal intensive care unit. Observations: All 9 patients were born between the ages of 24 and 29 weeks of gestation and had numerous complications associated with prematurity. Eight of the 9 infants were noted to have developed anetoderma on the trunk and proximal extremities while in the neonatal intensive care unit. The locations of the lesions on the skin were not explained by previous trauma, although many areas corresponded with placement of monitoring leads or with adhesive for a monitoring device. Reduction or absence of elastic tissue supported the diagnosis of anetoderma in 4 of 5 biopsy specimens. Conclusion: We report a previously unrecognized type of anetoderma associated with extreme prematurity. The exact cause is uncertain, although reactions to cutaneous monitoring leads or adhesives is suspected.(Arch Dermatol. 1996;132:671-674) References 1. Venencie PY, Winkelmann RK, Moore BA. Anetoderma . Arch Dermatol. 1984; 120:1032-1039.Crossref 2. Misch KJ, Rhodes EL, Allen J, Kersey P. Anetoderma of Jadassohn . J R Soc Med. 1988;81:734-736. 3. Schweninger E, Buzzi F. Multiple benign tumor-like new growths on the skin . In: Unna PG, Morris M, Besner E, et al, eds. International Atlas of Rare Skin Diseases . Hamburg, Germany: Leopold Voss; 1889-1899;5(chap 15, pt (1) ):4-5. 4. Jadassohn J. Ueber eine eigenartige Form von 'Atrophia Maculosa Cutis.' Arch Dermatol Syphilol. 1892;( (suppl 1) ):342-358. 5. Pellizari C. Eritema orticato atrofizzante: atrofia parziale idiopatica della pelle . G Ital Mal Ven 1884;19:230-243. 6. Venencie PY, Winkelman RK. Histopathologic findings in anetoderma . Arch Dermatol. 1984;120:1040-1044.Crossref 7. Muster AJ, Bharati S, Herman JJ, et al. Fatal cardiovascular disease and cutis laxa following acute febrile neutrophilic dermatosis . J Pediatr. 1983;102:243-248.Crossref 8. Golden SM. Skin craters: a complication of transcutaneous oxygen monitoring . Pediatrics. 1981;67:514-516. 9. Cartridge PHT, Fox PE, Rutter N. The scars of newborn intensive care . Early Hum Dev. 1990;21:1-10.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Jun 1, 1996

References