Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

SPLENIC PANHEMATOPENIA IN CHILDREN

SPLENIC PANHEMATOPENIA IN CHILDREN IN 1944, Doan1 described a blood dyscrasia which in his opinion was caused by a malfunctioning spleen. He pointed out certain similarities among this so-called panhematopenia, congenital hemolytic anemia and primary thrombopenic purpura. He postulated that in primary splenic panhematopenia the spleen does not exercise selectivity for any particular element of the blood in its pathologic destructive tendency, but that it destroys all of them at an excessive rate. Recently, Doan and Wright2 discussed this subject in more detail. In contrast to Doan's opinion, Dameshek3 expressed his feeling that the overactive spleen inhibits the bone marrow, possibly by hormonal control. Both authors emphasized the reality of the syndrome and pointed out the benefits of splenectomy in selected cases. Because of the paucity of reports of this syndrome descriptions of 2 cases are presented. REPORT OF CASES Case 1.—B. S., a white girl 11 years of age, was http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

Loading next page...
 
/lp/american-medical-association/splenic-panhematopenia-in-children-gglvxlKrqN

References (1)

Publisher
American Medical Association
Copyright
Copyright © 1950 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1950.04040010879009
Publisher site
See Article on Publisher Site

Abstract

IN 1944, Doan1 described a blood dyscrasia which in his opinion was caused by a malfunctioning spleen. He pointed out certain similarities among this so-called panhematopenia, congenital hemolytic anemia and primary thrombopenic purpura. He postulated that in primary splenic panhematopenia the spleen does not exercise selectivity for any particular element of the blood in its pathologic destructive tendency, but that it destroys all of them at an excessive rate. Recently, Doan and Wright2 discussed this subject in more detail. In contrast to Doan's opinion, Dameshek3 expressed his feeling that the overactive spleen inhibits the bone marrow, possibly by hormonal control. Both authors emphasized the reality of the syndrome and pointed out the benefits of splenectomy in selected cases. Because of the paucity of reports of this syndrome descriptions of 2 cases are presented. REPORT OF CASES Case 1.—B. S., a white girl 11 years of age, was

Journal

American journal of diseases of childrenAmerican Medical Association

Published: May 1, 1950

There are no references for this article.