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Splenectomy and Death in Renal Transplant Patients

Splenectomy and Death in Renal Transplant Patients Abstract To the Editor.—Peters et al1 reported that pretransplant splenectomy is associated with a threefold increase in posttransplant fatal infection. Their report was based on 191 patients having transplants between 1970 and 1981. Of these, 90 (47%) underwent pretransplant splenectomies. Thirty-two of 90 asplenic patients died of sepsis, compared with ten of 101 patients who had not undergone splenectomies. I suggest an alternative interpretation of their findings. The authors report that from 1970 to 1974 only four of 75 patients did not undergo a pretransplant bilateral nephrectomy, splenectomy, and appendectomy. Thus, 71 of their 90 asplenic transplant recipients received their grafts between 1970 and 1974. Ninety-seven of the 101 patients not undergoing a splenectomy had transplants between 1975 and 1981. During the decade between 1970 and 1980, transplant centers across the United States reported significant changes in their immunosuppressive protocols, leading to lowered total immunosuppression, a decreased infection rate, References 1. Peters TG, Williams JW, Harmon HC, et al: Splenectomy and death in renal transplant patients . Arch Surg 1983;118:795-799.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Splenectomy and Death in Renal Transplant Patients

Archives of Surgery , Volume 119 (4) – Apr 1, 1984

Splenectomy and Death in Renal Transplant Patients

Abstract

Abstract To the Editor.—Peters et al1 reported that pretransplant splenectomy is associated with a threefold increase in posttransplant fatal infection. Their report was based on 191 patients having transplants between 1970 and 1981. Of these, 90 (47%) underwent pretransplant splenectomies. Thirty-two of 90 asplenic patients died of sepsis, compared with ten of 101 patients who had not undergone splenectomies. I suggest an alternative interpretation of their findings. The authors report...
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Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1984.01390160107023
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.—Peters et al1 reported that pretransplant splenectomy is associated with a threefold increase in posttransplant fatal infection. Their report was based on 191 patients having transplants between 1970 and 1981. Of these, 90 (47%) underwent pretransplant splenectomies. Thirty-two of 90 asplenic patients died of sepsis, compared with ten of 101 patients who had not undergone splenectomies. I suggest an alternative interpretation of their findings. The authors report that from 1970 to 1974 only four of 75 patients did not undergo a pretransplant bilateral nephrectomy, splenectomy, and appendectomy. Thus, 71 of their 90 asplenic transplant recipients received their grafts between 1970 and 1974. Ninety-seven of the 101 patients not undergoing a splenectomy had transplants between 1975 and 1981. During the decade between 1970 and 1980, transplant centers across the United States reported significant changes in their immunosuppressive protocols, leading to lowered total immunosuppression, a decreased infection rate, References 1. Peters TG, Williams JW, Harmon HC, et al: Splenectomy and death in renal transplant patients . Arch Surg 1983;118:795-799.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Apr 1, 1984

References