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Spectinomycin Therapy for Gonorrhea in Prepubertal Children

Spectinomycin Therapy for Gonorrhea in Prepubertal Children Abstract • Twenty-six episodes of gonococcal urethritis or vulvovaginitis in 24 prepubertal patients were each treated with a single intramuscular (IM) dose of spectinomycin hydrochloride. Twenty-five episodes were treated successfully, and there were no side effects from this therapy. All tested isolates of Neisseria gonorrhoeae were susceptible in vitro to spectinomycin, and all serum levels one hour after therapy were in at least two-fold excess of the observed minimum inhibitory concentrations. Two patients had symptomatic and two had asymptomatic postgonococcal anogenital infections With Chlamydia trachomatis. A single dose of IM spectinomycin is a safe and efficacious regimen for uncomplicated gonococcal infection in prepubertal children who are penicillin-allergic or who have infections unresponsive or resistant to other antimicrobials, but it is not effective against incubating syphilis or chiamydial infection. (Am J Dis Child 134:359-363, 1980) References 1. Phillips I: β-Lactamase-producing, penicillin-resistant gonococcus . Lancet 2:656-657, 1976.Crossref 2. Center for Disease Control: Penicillinaseproducing Neisseria gonorrhoeae . Mordidity Mortality Weekly Rep 28:85-87, 1979. 3. Rendin RW, Bourgeois AL, Lin FL: Penicillinase-producing Neisseria gonorrhoeae in a prepubertal female . J Pediatr 94:431-432, 1979.Crossref 4. Center for Disease Control: Gonorrhea: CDC recommended treatment schedules, 1979 . Morbidity Mortality Weekly Rep 28:13-21, 1979. 5. Willcox RR: Trobicin (Actinospectacin): A new injectable antibiotic in the treatment of gonorrhea . Br J Vener Dis 38:150-153, 1962. 6. Duncan LW, Holder WR, Roberts DP, et al: Treatment of gonorrhea with spectinomycin hydrochloride: Comparison with standard penicillin schedules . Antimicrob Agents Chemother 1:210-214, 1972.Crossref 7. Pederson AHB, Weisner PJ, Holmes KK, et al: Spectinomycin and penicillin G in the treatment of gonorrhea . JAMA 220:205-208, 1972.Crossref 8. Mitchell RW, Robson HG: Single-dose treatment of gonococcal ureturitis in males: Evaluation of procaine penicillin, ampicillin, and spectinomycin . Can Med Assoc J 110:165-167, 1974. 9. Brown J, Tabert O, Hanna JD, et al: Treatment of gonorrheal ureturitis with spectinomycin hydrochloride . Can Med Assoc J 110:173-176, 1974. 10. Duanćić A, Fiumara NJ, Alpert S, et al: Comparison of spectinomycin hydrochloride and aqueous procaine penicillin G in the treatment of uncomplicated gonorrhea . Antimicrob Agents Chemother 6:512-515, 1974.Crossref 11. Judson FN, Allaman J, Dans PE: Treatment of gonorrhea: Comparison of penicillin G procaine, doxycycline, spectinomycin and ampicillin . JAMA 230:705-708, 1974.Crossref 12. Kousa M, Lassus A, Järueläinen R, et al: Spectinomycin hydrochloride in the treatment of uncomplicated gonorrhea in males and females . Br J Vener Dis 50:291-293, 1974. 13. Karney WK, Pedersen AHB, Nelson M, et al: Spectinomycin versus tetracycline for the treatment of gonorrhea . N Engl J Med 296:889-894, 1977.Crossref 14. Wentworth BB, Alexander ER: Isolation of Chlamydia trachomatis by use of 5-iodo-2-deoxyuridine-treated cells . Appl Microbiol 27:912-916, 1974. 15. Jorgensen JG, Lee JC, Alexander GA: Rapid penicillinase paper strip test for detection of beta-lactamase-producing Haemophilus influenzae and Neisseria gonorrhoeae . Antimicrob Agents Chemother 11:1087-1088, 1977.Crossref 16. Rettig PJ, Hieber JP, Nelson JD: Postgonococcal chlamydial infection in prepubertal children , abstracted. Soc Pediatr Res 13:466, 1979. 17. Arya OP, Rees E, Percival A, et al: Epidemiology and treatment of gonorrhea caused by penicillinase-producing strains in Liverpool . Br J Vener Dis 54:28-35, 1978. 18. Siegel MS, Thornsberry C, Weisner PJ: Penicillinase-producing Neisseria gonorrhoeae: Results of surveillance in the United States , in Siegenthaler W, Lüthy R (eds): Proceedings of the Tenth International Conference on Chemotherapy . Washington, DC, American Society for Microbiology, 1978, vol 1, pp 192-194. 19. Nelson JD, Mohs E, Dajani AS, et al: Gonorrhea in preschool- and school-aged children. Report of the Prepubertal Gonorrhea Cooperative Study Group . JAMA 236:1359-1364, 1976.Crossref 20. Branch G, Paxton R: A study of gonococcal infections among infants and children . Public Health Rep 80:347-352, 1965.Crossref 21. Porter IA, Wood WJ: Spectinomycin: Minimum inhibitory concentrations for Neisseria gonorrhoeae . Br J Vener Dis 50:239-240, 1974. 22. Jaffe HW, Biddle JW, Thornsberry C, et al: National Gonorrhea Therapy Monitoring Study: In vitro antibiotic susceptibility and its correlation with treatment results . N Engl J Med 294:5-9, 1976.Crossref 23. Thornsberry C, Biddle JW, Perine PL, et al: Susceptibility of Neisseria gonorrhoeae from the United States and the Far East (β-lactamase negative and positive) to antimicrobial agents , in Brooks GF, Botschlich EC, Holmes KK, et al (eds): Immunobiology of Neisseria gonorrhoeae . Washington, DC, American Society for Microbiology, 1978, pp 62-67. 24. Reyn A, Schmidt H, Trier M, et al: Spectinomycin hydrochloride (Trobicin) in the treatment of gonorrhea: Observation of resistant strains of Neisseria gonorrhoeae . Br J Vener Dis 49:54-59, 1973. 25. Thornsberry C, Jaffe H, Brown ST, et al: Spectinomycin-resistant Neisseria gonorrhoeae . JAMA 237:2405-2406, 1977.Crossref 26. Brownlow WJ, Watko LP, Aucoin EJ, et al: Treatment of gonorrhoea contracted in Western Pacific Region . Br J Vener Dis 50:113-116, 1974. 27. Oriel JD, Ridgway GL, Tchamouroff S, et al: Spectinomycin hydrochloride in the treatment of gonorrhoea: Its effect on associated Chlamydia trachomatis infections . Br J Vener Dis 53:226-229, 1977. 28. Washington JA, Yu PKW: In vitro antibacterial activity of spectinomycin . Antimicrob Agents Chemother 2:427-430, 1972.Crossref 29. Wagner IG, Novak E, Leslie LG, et al: Absorption, distribution and elimination of spectinomycin dihydrochloride in man . Int J Clin Pharmacol 1:261-285, 1968. 30. Barry JM, Koch R: Actinospectacin serum levels and clinical data , in Sylvester JC (ed): Antimicrobial Agents and Chemotherapy—1962 . Washington, DC, American Society for Microbiology, 1963, pp 538-542. 31. McCormack WM, Finland M: Spectinomycin . Ann Intern Med 84:712-716, 1976.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Spectinomycin Therapy for Gonorrhea in Prepubertal Children

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American Medical Association
Copyright
Copyright © 1980 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1980.04490010017006
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Abstract

Abstract • Twenty-six episodes of gonococcal urethritis or vulvovaginitis in 24 prepubertal patients were each treated with a single intramuscular (IM) dose of spectinomycin hydrochloride. Twenty-five episodes were treated successfully, and there were no side effects from this therapy. All tested isolates of Neisseria gonorrhoeae were susceptible in vitro to spectinomycin, and all serum levels one hour after therapy were in at least two-fold excess of the observed minimum inhibitory concentrations. Two patients had symptomatic and two had asymptomatic postgonococcal anogenital infections With Chlamydia trachomatis. A single dose of IM spectinomycin is a safe and efficacious regimen for uncomplicated gonococcal infection in prepubertal children who are penicillin-allergic or who have infections unresponsive or resistant to other antimicrobials, but it is not effective against incubating syphilis or chiamydial infection. (Am J Dis Child 134:359-363, 1980) References 1. Phillips I: β-Lactamase-producing, penicillin-resistant gonococcus . Lancet 2:656-657, 1976.Crossref 2. Center for Disease Control: Penicillinaseproducing Neisseria gonorrhoeae . Mordidity Mortality Weekly Rep 28:85-87, 1979. 3. Rendin RW, Bourgeois AL, Lin FL: Penicillinase-producing Neisseria gonorrhoeae in a prepubertal female . J Pediatr 94:431-432, 1979.Crossref 4. Center for Disease Control: Gonorrhea: CDC recommended treatment schedules, 1979 . Morbidity Mortality Weekly Rep 28:13-21, 1979. 5. Willcox RR: Trobicin (Actinospectacin): A new injectable antibiotic in the treatment of gonorrhea . Br J Vener Dis 38:150-153, 1962. 6. Duncan LW, Holder WR, Roberts DP, et al: Treatment of gonorrhea with spectinomycin hydrochloride: Comparison with standard penicillin schedules . Antimicrob Agents Chemother 1:210-214, 1972.Crossref 7. Pederson AHB, Weisner PJ, Holmes KK, et al: Spectinomycin and penicillin G in the treatment of gonorrhea . JAMA 220:205-208, 1972.Crossref 8. Mitchell RW, Robson HG: Single-dose treatment of gonococcal ureturitis in males: Evaluation of procaine penicillin, ampicillin, and spectinomycin . Can Med Assoc J 110:165-167, 1974. 9. Brown J, Tabert O, Hanna JD, et al: Treatment of gonorrheal ureturitis with spectinomycin hydrochloride . Can Med Assoc J 110:173-176, 1974. 10. Duanćić A, Fiumara NJ, Alpert S, et al: Comparison of spectinomycin hydrochloride and aqueous procaine penicillin G in the treatment of uncomplicated gonorrhea . Antimicrob Agents Chemother 6:512-515, 1974.Crossref 11. Judson FN, Allaman J, Dans PE: Treatment of gonorrhea: Comparison of penicillin G procaine, doxycycline, spectinomycin and ampicillin . JAMA 230:705-708, 1974.Crossref 12. Kousa M, Lassus A, Järueläinen R, et al: Spectinomycin hydrochloride in the treatment of uncomplicated gonorrhea in males and females . Br J Vener Dis 50:291-293, 1974. 13. Karney WK, Pedersen AHB, Nelson M, et al: Spectinomycin versus tetracycline for the treatment of gonorrhea . N Engl J Med 296:889-894, 1977.Crossref 14. Wentworth BB, Alexander ER: Isolation of Chlamydia trachomatis by use of 5-iodo-2-deoxyuridine-treated cells . Appl Microbiol 27:912-916, 1974. 15. Jorgensen JG, Lee JC, Alexander GA: Rapid penicillinase paper strip test for detection of beta-lactamase-producing Haemophilus influenzae and Neisseria gonorrhoeae . Antimicrob Agents Chemother 11:1087-1088, 1977.Crossref 16. Rettig PJ, Hieber JP, Nelson JD: Postgonococcal chlamydial infection in prepubertal children , abstracted. Soc Pediatr Res 13:466, 1979. 17. Arya OP, Rees E, Percival A, et al: Epidemiology and treatment of gonorrhea caused by penicillinase-producing strains in Liverpool . Br J Vener Dis 54:28-35, 1978. 18. Siegel MS, Thornsberry C, Weisner PJ: Penicillinase-producing Neisseria gonorrhoeae: Results of surveillance in the United States , in Siegenthaler W, Lüthy R (eds): Proceedings of the Tenth International Conference on Chemotherapy . Washington, DC, American Society for Microbiology, 1978, vol 1, pp 192-194. 19. Nelson JD, Mohs E, Dajani AS, et al: Gonorrhea in preschool- and school-aged children. Report of the Prepubertal Gonorrhea Cooperative Study Group . JAMA 236:1359-1364, 1976.Crossref 20. Branch G, Paxton R: A study of gonococcal infections among infants and children . Public Health Rep 80:347-352, 1965.Crossref 21. Porter IA, Wood WJ: Spectinomycin: Minimum inhibitory concentrations for Neisseria gonorrhoeae . Br J Vener Dis 50:239-240, 1974. 22. Jaffe HW, Biddle JW, Thornsberry C, et al: National Gonorrhea Therapy Monitoring Study: In vitro antibiotic susceptibility and its correlation with treatment results . N Engl J Med 294:5-9, 1976.Crossref 23. Thornsberry C, Biddle JW, Perine PL, et al: Susceptibility of Neisseria gonorrhoeae from the United States and the Far East (β-lactamase negative and positive) to antimicrobial agents , in Brooks GF, Botschlich EC, Holmes KK, et al (eds): Immunobiology of Neisseria gonorrhoeae . Washington, DC, American Society for Microbiology, 1978, pp 62-67. 24. Reyn A, Schmidt H, Trier M, et al: Spectinomycin hydrochloride (Trobicin) in the treatment of gonorrhea: Observation of resistant strains of Neisseria gonorrhoeae . Br J Vener Dis 49:54-59, 1973. 25. Thornsberry C, Jaffe H, Brown ST, et al: Spectinomycin-resistant Neisseria gonorrhoeae . JAMA 237:2405-2406, 1977.Crossref 26. Brownlow WJ, Watko LP, Aucoin EJ, et al: Treatment of gonorrhoea contracted in Western Pacific Region . Br J Vener Dis 50:113-116, 1974. 27. Oriel JD, Ridgway GL, Tchamouroff S, et al: Spectinomycin hydrochloride in the treatment of gonorrhoea: Its effect on associated Chlamydia trachomatis infections . Br J Vener Dis 53:226-229, 1977. 28. Washington JA, Yu PKW: In vitro antibacterial activity of spectinomycin . Antimicrob Agents Chemother 2:427-430, 1972.Crossref 29. Wagner IG, Novak E, Leslie LG, et al: Absorption, distribution and elimination of spectinomycin dihydrochloride in man . Int J Clin Pharmacol 1:261-285, 1968. 30. Barry JM, Koch R: Actinospectacin serum levels and clinical data , in Sylvester JC (ed): Antimicrobial Agents and Chemotherapy—1962 . Washington, DC, American Society for Microbiology, 1963, pp 538-542. 31. McCormack WM, Finland M: Spectinomycin . Ann Intern Med 84:712-716, 1976.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Apr 1, 1980

References