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In spite of the fact that the treatment of allergic conditions is fairly satisfactory, the fact remains that treatment is largely empiric. Advantage is taken of the fact that allergic persons frequently show skin reactions to their respective allergens to determine the specific allergenic substances, but there are many irregularities found in skin reactivity and the reasons for them are imperfectly understood. Treatment with the substance to which the patient is sensitive frequently produces good results, but there is still much room for argument as to the mechanism underlying the response to treatment. Some of the problems found in an attempt to explain these conditions are due to deficiencies in the knowledge of immunology in general, but some of them may be solved by careful, concerted study by the clinical investigator and the laboratory worker. In this field where animal experimentation may fail to reproduce human reactions, accurate observation of
JAMA – American Medical Association
Published: Jul 2, 1932
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