Abstract • Solitary small very dark and papular pigmented nevi, less than 4 mm, are seen commonly in the second decade of life and have a distinctive histologic pattern. Microscopically these lesions show abundant intraepidermal melanin, included within the keratin layer, and proliferating single melanocytes or nevus cell nests. Prominent nucleoli in the melanocytic cells, occasional mitoses, and the invariable presence of moderate numbers of dermal melanophages and lymphocytes indicated the activity of the pathologic process. The benignity of the lesions in nine patients is supported by a benign course over a one-to three-year evaluation period after limited excisional biopsy procedures. The clinical and pathologic evidence of activity in these nevi suggests yet another possible precursor of malignant melanoma. The B-K mole syndrome and the dysplastic nevi syndrome differ from these cases both clinically and histologically. (Arch Dermatol 1983;119:35-38) References 1. Clark WH Jr, Reimer RR, Greene M, et al: Origin of familial malignant melanoma from heritable melanocytic lesions . Arch Dermatol 1978;144:732-738.Crossref 2. Elder DE, Goldman LI, Goldman SC, et al: Dysplastic nevus syndrome: A phenotypic association of sporadic cutaneous melanoma . Cancer 1980;46:1787-1794.Crossref 3. Price NM, Rywlin AM, Ackerman BA: Histologic criteria for the diagnosis of superficial spreading malignant melanoma formulated on the basis of proven metastatic lesions . Cancer 1976;38:2434-2441.Crossref 4. Couperus M, Rucker RC: Histopathological diagnosis of malignant melanoma . Arch Dermatol 1954;70:199-216.Crossref 5. Caro MR: Diagnostic pitfalls of dermal pathology . Arch Dermatol 1953;67:18-29.Crossref 6. Milton GW: The diagnosis of melanoma, in McCarthy WH (ed): Melanoma and Skin Cancer. Sydney, Australia, VCN Blight, Government Printer, 1972. 7. Lund HZ, Stobbe GD: The natural history of the pigmented nevus: Factors of age and anatomic location . Am J Pathol 1949;25:1117-1147. 8. Stegmaier OC Jr, Montgomery H: Histopathologic studies of pigmented nevi in children . J Invest Dermatol 1953;20:51-64. 9. Spitz S: Melanomas of children . Am J Pathol 1948;24:591-610. 10. Becker SW: Critical evaluation of the so-called "junctional nevus." J Invest Dermatol 1954;22:217-223.Crossref 11. Allen AC, Spitz S: Malignant melanoma: A clinicopathological analysis of the criteria for diagnosis and prognosis . Cancer 1953;6:1-45.Crossref 12. Okun MR: Melanoma resembling spindle and epithelioid cell nevus: Report of three cases . Arch Dermatol 1979;115:1416-1420.Crossref 13. Rahbari H, Mehregan AH: Sporadic atypical mole syndrome . Arch Dermatol 1981;117:329-331.Crossref 14. Kornberg R, Ackerman BA: Pseudomelanoma: Recurrent melanocytic nevus following partial surgical removal . Arch Dermatol 1975;111:1588-1590.Crossref 15. Eady RAJ, Gilkes JJH, Jones EW: Eruptive naevi: Report of two cases with enzyme histochemical light and electron microscopical finding . Br J Dermatol 1977;97:267-278.Crossref
Archives of Dermatology – American Medical Association
Published: Jan 1, 1983
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