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Solar Urticaria: Investigation of Pathogenetic Mechanisms

Solar Urticaria: Investigation of Pathogenetic Mechanisms Abstract A 29-year-old white man experienced a rather sudden onset of solar urticaria. The action spectrum ranged from about 250 nm to about 330 nm, but no wheal could be elicited in certain portions of his skin. The phenomenon was blocked by local injection of epinephrine and by arterial occlusion. A serum factor was demonstrated by passive and reverse passive transfer. Evans blue studies demonstrated that albumin from the serum entered the wheals as they formed. Histamine probably has no part in the production of this wheal as evidenced by the inability of locally-injected antihistamines or histamine depletion to alter the response. In addition, neither histamine nor kinin was detected in repeated dermal perfusion. References 1. Merklen, P.: " Urticaire ," in Besnier, E.; Brocq, L., and Jacquet, L. (eds.): La Pratique Dermatologique , Paris: Masson & Cie, 1904, pp 728-771. 2. Harber, L.C., et al: Immunologic and Biophysical Studies in Solar Urticaria , J Invest Derm 41:439-443 ( (Dec) ) 1963.Crossref 3. Winkelmann, R.K.: Technic of Dermal Perfusion , J Invest Derm 46:220-223 ( (Feb) ) 1966. 4. Winkelmann, R.K.; Vesper, L.J.; and Horner, F.A.: Histamine Release From the Skin of Patients With Cutaneous Mast Cell Disease (Urticaria Pigmentosa) , Acta Dermatovener (Stockholm) 46:279-284, 1966. 5. Epstein, J.H., and Winkelmann, R.K.: Ultraviolet Light-Induced Kinin Formation in Human Skin , Arch Derm 95:532-536 ( (May) ) 1967.Crossref 6. Epstein, J.H.; Vandenberg, J.J.; and Wright, W.L.: Solar Urticaria , Arch Derm 88:135-141 ( (Aug) ) 1963.Crossref 7. Magnus, I.A., and Porter, A.D.: A Case of Urticaria Solaris Studied With a Monochromator , Brit J Derm 71:51-60 ( (Feb) ) 1959.Crossref 8. Epstein, S.: Allergische Lichtdermatosen , Dermatologica (Basel) 80:291-320 ( (Dec) ) 1939.Crossref 9. Baer, R.L., and Harber, L.C.: " Reactions to Light, Heat, and Trauma ," in Samter, M., and Alexander, H.L. (eds.): Immunological Diseases , Boston: Little, Brown & Company, 1965, pp 704-712. 10. Sulzberger, M.B., and Baer, R.L.: Studies in Hypersensitivity to Light: I. Preliminary Report , J Invest Derm 6:345-348 ( (Dec) ) 1945.Crossref 11. Winkelmann, R.K.; Wilhelmj, C.M.; and Horner, F.A.: Experimental Studies on Dermographism , Arch Derm 92:436-442 ( (Oct) ) 1965.Crossref 12. DeLaus, F.V., and Winkelmann, R.K.: Kinins in Cold Urticaria: A Clinical Study , Arch Derm , 98:67-74 ( (July) ) 1968.Crossref 13. Olson, R.L.; Sayre, R.M.; and Everett, M.A.: Effect of Anatomic Location and Time on Ultraviolet Erythema , Arch Derm 93:211-215 ( (Feb) ) 1966.Crossref 14. Blum, H.F., and West, R.J.: Studies of an Urticarial Response to Blue and Violet Light in Man , J Clin Invest 16:261-277 ( (March) ) 1937.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Solar Urticaria: Investigation of Pathogenetic Mechanisms

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References (16)

Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1969.01610220018003
Publisher site
See Article on Publisher Site

Abstract

Abstract A 29-year-old white man experienced a rather sudden onset of solar urticaria. The action spectrum ranged from about 250 nm to about 330 nm, but no wheal could be elicited in certain portions of his skin. The phenomenon was blocked by local injection of epinephrine and by arterial occlusion. A serum factor was demonstrated by passive and reverse passive transfer. Evans blue studies demonstrated that albumin from the serum entered the wheals as they formed. Histamine probably has no part in the production of this wheal as evidenced by the inability of locally-injected antihistamines or histamine depletion to alter the response. In addition, neither histamine nor kinin was detected in repeated dermal perfusion. References 1. Merklen, P.: " Urticaire ," in Besnier, E.; Brocq, L., and Jacquet, L. (eds.): La Pratique Dermatologique , Paris: Masson & Cie, 1904, pp 728-771. 2. Harber, L.C., et al: Immunologic and Biophysical Studies in Solar Urticaria , J Invest Derm 41:439-443 ( (Dec) ) 1963.Crossref 3. Winkelmann, R.K.: Technic of Dermal Perfusion , J Invest Derm 46:220-223 ( (Feb) ) 1966. 4. Winkelmann, R.K.; Vesper, L.J.; and Horner, F.A.: Histamine Release From the Skin of Patients With Cutaneous Mast Cell Disease (Urticaria Pigmentosa) , Acta Dermatovener (Stockholm) 46:279-284, 1966. 5. Epstein, J.H., and Winkelmann, R.K.: Ultraviolet Light-Induced Kinin Formation in Human Skin , Arch Derm 95:532-536 ( (May) ) 1967.Crossref 6. Epstein, J.H.; Vandenberg, J.J.; and Wright, W.L.: Solar Urticaria , Arch Derm 88:135-141 ( (Aug) ) 1963.Crossref 7. Magnus, I.A., and Porter, A.D.: A Case of Urticaria Solaris Studied With a Monochromator , Brit J Derm 71:51-60 ( (Feb) ) 1959.Crossref 8. Epstein, S.: Allergische Lichtdermatosen , Dermatologica (Basel) 80:291-320 ( (Dec) ) 1939.Crossref 9. Baer, R.L., and Harber, L.C.: " Reactions to Light, Heat, and Trauma ," in Samter, M., and Alexander, H.L. (eds.): Immunological Diseases , Boston: Little, Brown & Company, 1965, pp 704-712. 10. Sulzberger, M.B., and Baer, R.L.: Studies in Hypersensitivity to Light: I. Preliminary Report , J Invest Derm 6:345-348 ( (Dec) ) 1945.Crossref 11. Winkelmann, R.K.; Wilhelmj, C.M.; and Horner, F.A.: Experimental Studies on Dermographism , Arch Derm 92:436-442 ( (Oct) ) 1965.Crossref 12. DeLaus, F.V., and Winkelmann, R.K.: Kinins in Cold Urticaria: A Clinical Study , Arch Derm , 98:67-74 ( (July) ) 1968.Crossref 13. Olson, R.L.; Sayre, R.M.; and Everett, M.A.: Effect of Anatomic Location and Time on Ultraviolet Erythema , Arch Derm 93:211-215 ( (Feb) ) 1966.Crossref 14. Blum, H.F., and West, R.J.: Studies of an Urticarial Response to Blue and Violet Light in Man , J Clin Invest 16:261-277 ( (March) ) 1937.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Apr 1, 1969

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