Abstract Since our1 first studies of the polymorphic light-sensitive eruptions were reported, an effort has been made to study further the clinical and microscopic means of differentiation of solar dermatitis and discoid lupus erythematosus. Sufficient time has elapsed to evaluate certain therapeutic ideas suggested in the earlier study, i. e., the value of hormonal therapy and the use of the antimalarial drugs such as chloroquine and quinacrine (Atabrine). Clinical Differentiation Clinical differentiation of plaque-like (the commonest type) polymorphic light eruption and discoid lupus erythematosus is not difficult in most cases and may be summarized as follows: The papular and prurigo-like type of polymorphic light eruption does not offer any confusion with lupus erythematosus; this is a rarer form of the disease. Some of the patients have had prurigo aestivalis since childhood. The line of division from the plaque-like variety, however, is most difficult in many cases References 1. Lamb, J. H.; Shelmire, J. B., and others: Solar Dermatitis , Arch. Dermat. & Syph. 62:1-27 ( (July) ) 1950. 2. Cahn, M. H.; Levy, E. J.; Shaffer, B., and Beerman, H.: Lupus Erythematosus and Polymorphous Light Eruptions , J. Invest. Dermat. 21:375-396 ( (Dec.) ) 1953. 3. Selisky, A. B.: Neue Behandlungsmethode von Lichtdermatosen , Dermat. Wchnschr. , 101:1299-1302 ( (Oct. 19) ) 1935. 4. Lancaster, A. H.: Estrogenic Hormone Therapy in Sunlight Eruptions of the Female , South. M. J. 32:495, 1939. 5. Lain, E. S.; Lamb, J. H.; Keaty, C., and Hellbaum, A. A.: The Use of the Steroid and Gonadotropic Hormones in Hydroa Vacciniforme , South. M. J. 41:1041-1045 ( (Nov.) ) 1948. 6. Stokes, J. H.; Beerman, H., and Ingraham, N. R.: Photodynamic Effects in Dermatology , Am. J. M. Sc. 203:608 ( (April) ) 1942. 7. Reynolds, S. R. M., and Foster, F. I.: Peripheral Vascular Action of Estrogen in the Human Male , J. Clin. Invest. 18:649 ( (Nov.) ) 1939. 8. Rothman, S., and others: Physiology and Biochemistry of the Skin , Chicago, University of Chicago Press, 1954, pp. 298-382. 9. Miescher, G.: Das Problem des Lichtschutzes und der Lichtgewöhnung , Strahlentherapie 35:403-443, 1930. 10. Szirmai, J. A.: The Effect of Testosterone in the Connective Tissue of the Head, Appendices and the Skin of the Capon , Anat. Record , 105:337-359 ( (Oct.) ) 1949. 11. Hardesty, M.: The Structural Basis for the Response of the Comb of the Brown Leghorn Fowl to Sex Hormones , Am. J. Anat. 47:277, 1951. 12. Wooldridge, W. E.: Personal communications 13. Morgan, R. J.; Shackelford, P. O., and Lamb,A.. H.: Unusual Forms of Solar Dermatitis , A. M. A. Arch. Dermat. & Syph. 67:369-379 ( (April) ) 1953. 14. Knox, J. M.; Lamb, J. H.; Shelmire, J. B., and Morgan, R. J.: Light-Sensitive Eruptions Treated with Atabrine and Chloroquine , J. Invest. Dermat. 22:11-16 ( (Jan.) ) 1954. 15. Woodburne, A. R.; Philpott, O. S., and Philpott, J. A.: Quinacrine (Atabrine) in Treatment of Solar Dermatoses , A. M. A. Arch. Dermat. & Syph. 70:116-118 ( (July) ) 1954.
A.M.A. Archives of Dermatology – American Medical Association
Published: Feb 1, 1957