Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Small-Intestinal Histopathology and Mortality Risk in Celiac Disease

Small-Intestinal Histopathology and Mortality Risk in Celiac Disease ORIGINAL CONTRIBUTION Small-Intestinal Histopathology and Mortality Risk in Celiac Disease Jonas F. Ludvigsson, MD, PhD Context Studies of mortality in celiac disease have not taken small-intestinal pathol- ogy into account. Scott M. Montgomery, PhD Anders Ekbom, MD, PhD Objective To examine mortality in celiac disease according to small-intestinal his- topathology. Lena Brandt, BSc Design, Setting, and Patients Retrospective cohort study. We collected data from Fredrik Granath, PhD duodenal/jejunal biopsies taken between July 1969 and February 2008 on celiac dis- ease (Marsh stage 3: villous atrophy; n=29 096 individuals) and inflammation (Marsh ELIAC DISEASE IS AN IMMUNE- stage 1-2; n=13 306) from all 28 pathology departments in Sweden. A third cohort mediated disorder that is trig- consisted of individuals with latent celiac disease from 8 university hospitals (n=3719). gered by gluten exposure in Latent celiac disease was defined as positive celiac disease serology in individuals with Cgenetically sensitive individu- normal mucosa (Marsh stage 0). Through linkage with the Swedish Total Population als, occurring in about 1% of the West- Register, we estimated the risk of death through August 31, 2008, compared with ern population. age- and sex-matched controls from the general population. With few exceptions, research has Main Outcome Measure http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Small-Intestinal Histopathology and Mortality Risk in Celiac Disease

Loading next page...
 
/lp/american-medical-association/small-intestinal-histopathology-and-mortality-risk-in-celiac-disease-51tD2C3yiq
Publisher
American Medical Association
Copyright
Copyright 2009 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2009.1320
pmid
19755695
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION Small-Intestinal Histopathology and Mortality Risk in Celiac Disease Jonas F. Ludvigsson, MD, PhD Context Studies of mortality in celiac disease have not taken small-intestinal pathol- ogy into account. Scott M. Montgomery, PhD Anders Ekbom, MD, PhD Objective To examine mortality in celiac disease according to small-intestinal his- topathology. Lena Brandt, BSc Design, Setting, and Patients Retrospective cohort study. We collected data from Fredrik Granath, PhD duodenal/jejunal biopsies taken between July 1969 and February 2008 on celiac dis- ease (Marsh stage 3: villous atrophy; n=29 096 individuals) and inflammation (Marsh ELIAC DISEASE IS AN IMMUNE- stage 1-2; n=13 306) from all 28 pathology departments in Sweden. A third cohort mediated disorder that is trig- consisted of individuals with latent celiac disease from 8 university hospitals (n=3719). gered by gluten exposure in Latent celiac disease was defined as positive celiac disease serology in individuals with Cgenetically sensitive individu- normal mucosa (Marsh stage 0). Through linkage with the Swedish Total Population als, occurring in about 1% of the West- Register, we estimated the risk of death through August 31, 2008, compared with ern population. age- and sex-matched controls from the general population. With few exceptions, research has Main Outcome Measure

Journal

JAMAAmerican Medical Association

Published: Sep 16, 2009

References