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MORE THAN 100 patients have been surgically treated for Parkinson's disease in the last two years. However, it is still uncertain whether the procedure, which involves the transplantation of tissue from the adrenal medulla to the caudate nucleus of the brain, has lasting benefits. None of the neurosurgeons performing the operation in the United States have been able to duplicate the dramatic improvement reported by Ignacio Madrazo, MD (New Engl J Med 1987; 316:831-834), and presented at scientific sessions. Madrazo's videotapes, aired at last summer's Schmitt Symposium on Transplantion Into the Mammalian Brain in Rochester, NY, showed patients who were once confined to wheelchairs walking with relative ease. In contrast, the experience in the United States has been one in which patients have demonstrated far less dramatic improvements. The disparity was brought to light at the annual meeting of the American Academy of Neurology in Cincinnati this spring, when groups
JAMA – American Medical Association
Published: Jul 22, 1988
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