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`Slow Down and Proceed With Caution' Is New Rule for Brain-Graft Surgeons

`Slow Down and Proceed With Caution' Is New Rule for Brain-Graft Surgeons MORE THAN 100 patients have been surgically treated for Parkinson's disease in the last two years. However, it is still uncertain whether the procedure, which involves the transplantation of tissue from the adrenal medulla to the caudate nucleus of the brain, has lasting benefits. None of the neurosurgeons performing the operation in the United States have been able to duplicate the dramatic improvement reported by Ignacio Madrazo, MD (New Engl J Med 1987; 316:831-834), and presented at scientific sessions. Madrazo's videotapes, aired at last summer's Schmitt Symposium on Transplantion Into the Mammalian Brain in Rochester, NY, showed patients who were once confined to wheelchairs walking with relative ease. In contrast, the experience in the United States has been one in which patients have demonstrated far less dramatic improvements. The disparity was brought to light at the annual meeting of the American Academy of Neurology in Cincinnati this spring, when groups http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

`Slow Down and Proceed With Caution' Is New Rule for Brain-Graft Surgeons

JAMA , Volume 260 (4) – Jul 22, 1988

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Publisher
American Medical Association
Copyright
Copyright © 1988 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1988.03410040015002
Publisher site
See Article on Publisher Site

Abstract

MORE THAN 100 patients have been surgically treated for Parkinson's disease in the last two years. However, it is still uncertain whether the procedure, which involves the transplantation of tissue from the adrenal medulla to the caudate nucleus of the brain, has lasting benefits. None of the neurosurgeons performing the operation in the United States have been able to duplicate the dramatic improvement reported by Ignacio Madrazo, MD (New Engl J Med 1987; 316:831-834), and presented at scientific sessions. Madrazo's videotapes, aired at last summer's Schmitt Symposium on Transplantion Into the Mammalian Brain in Rochester, NY, showed patients who were once confined to wheelchairs walking with relative ease. In contrast, the experience in the United States has been one in which patients have demonstrated far less dramatic improvements. The disparity was brought to light at the annual meeting of the American Academy of Neurology in Cincinnati this spring, when groups

Journal

JAMAAmerican Medical Association

Published: Jul 22, 1988

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