Abstract • Slipped capital femoral epiphysis (SCFE), a potentially disabling hip disorder, occurs primarily during the pubertal growth spurt. It has been reported in association with pituitary gigantism, growth hormone deficiency, hypothyroidism, hypogonadism, and panhypopituitarism. We estimated the frequency of SCFE among children with growth hormone deficiency (treated or untreated) and compared it with the reported frequency of SCFE among Connecticut residents under 25 years of age. Based on this comparison, the risk of developing SCFE is significantly greater in growth hormone–deficient children than in the general population. (AJDC 1985;139:396-399) References 1. Hendrikson B: The incidence of slipped capital femoral epiphysis . Acta Orthop Scand 1969;40:365-372.Crossref 2. Kelsey JL: The incidence and distribution of slipped capital femoral epiphysis in Connecticut and southwestern United States . J Bone Joint Surgery Am 1970;52:1203-1215. 3. Kelsey JL: The incidence and distribution of slipped capital femoral epiphysis in Connecticut . J Chronic Dis 1971;23:567-578.Crossref 4. Alexander CJ: Effect of growth rate on the strength of the growth plate . Skeletal Radiol 1976;1:67-76.Crossref 5. Harris RW: The endocrine basis for slipping of the upper femoral epiphysis . J Bone Joint Surg Br 1950;31:5-11. 6. Semple JC, Goldschmidt RG: Epiphyseal maturation and slipping femoral epiphysis in a hypopituitary dwarf . Orthopaedics 1969;2:31-42. 7. Reeves GD, Gibbs M, Paulshock BZ, et al: Gigantism with slipped capital femoral epiphysis . AJDC 1978;132:529-530. 8. Aceto T Jr, Frasier SD, Hayes AB, et al: Collaborative study of the effects of human growth hormone in growth hormone deficiency: III. First 18 months of therapy , in Raiti S (ed): Advances in Human Growth Hormone Research , publication (NIH) 74-612. Bethesda, Md, Dept of Health, Education, and Welfare, 1973, p 708. 9. Rennie W, Mitchell N: Slipped femoral capital epiphysis occurring during growth hormone therapy . J Bone Joint Surg Br 1974;56:703-705. 10. Fidler MW, Brook CGD: Slipped upper femoral epiphysis following treatment with human growth hormone . J Bone Joint Surg Am 1974;56:1719-1722. 11. Hirsch PJ, Hirsch SA: Slipped capital femoral epiphysis: Occurrence after treatment with chorionic gonadotropin . JAMA 1976;235:751.Crossref 12. Zubrow AB, Lane JA, Parks JS: Slipped capital femoral epiphysis occurring during treatment for hypothyroidism . J Bone Joint Surg Am 1978;60:256-258. 13. Crawford AH, MacEwen GD, Fonte D: Slipped capital femoral epiphysis co-existent with hypothyroidism . Clin Orthop Rel Res 1977;122:135-140. 14. Al-Aswad BI, Weinger JM, Schneider AB: Slipped capital femoral epiphysis in a 35-year-old man . Clin Orthop Rel Res 1978;134:131-134. 15. Hirano T, Stamelos S, Harris V, et al: Association of primary hypothyroidism and slipped capital femoral epiphysis . J Pediatr 1978; 93:262-264.Crossref 16. Jayakumar S: Slipped capital femoral epiphysis with hypothyroidism treated by nonoperative method . Clin Orthop Rel Res 1980;151: 179-182. 17. Hennessy MJ, Jones KL: Slipped capital femoral epiphysis in hypothyroid adult male . Clin Orthop Rel Res 1982;165:204-208. 18. Ogden JA, Southwick WO: Endocrine dysfunction and slipped capital femoral epiphysis . Yale J Biol Med 1977;50:1-16. 19. Burns EC, Tanner JM, Preece MA, et al: Growth hormone treatment in children with craniopharyngioma: Final growth status . Clin Endocrinol 1981;14:587-595.Crossref 20. Heatley FW, Greenwood RH, Boase DL: Slipping of the upper femoral epiphysis in patients with intracranial tumours causing hypopituitarism and chiasmal compression . J Bone Joint Surg Br 1976;58:169-175. 21. Chung S: Diseases of the developing hip joint . Pediatr Clin North Am 1977;24:857-870. 22. Molloy MK, MacMahon B: Incidence of Legg-Perthes disease (osteochondritis deformans) . N Engl J Med 1966;275:988-990.Crossref
American Journal of Diseases of Children – American Medical Association
Published: Apr 1, 1985
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