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Sleep Hypoxemia in Patients With Cystic Fibrosis

Sleep Hypoxemia in Patients With Cystic Fibrosis Abstract Twovolved in the demonstration of sleep hypoxemia in patients with cystic fibrosis. First, the degrees of arterial oxygen desaturation presently shown by Francis et al (see p 734) may be great enough to accelerate the progress of cor pulmonale. Second, disturbance of the normal sleep pattern is a problem recognized by patients with advanced pulmonary disease. It certainly worsens their quality of life and may well hasten the course of the disease itself. Relationships between sleep state and breathing are now studied with great interest by researchers in respiratory physiology, neurophysiology, and anesthesiology. New techniques allow meaningful descriptions of sleep state, activity of respiratory muscles, mechanics of breathing, and changes in arterial blood gas levels. However, the pertinent questions arose from clinical observations. Adults with severe chronic obstructive pulmonary disease have long been known to suffer reversal of the normal sleep pattern; they have increasing wakefulness at night and somnolence References 1. Sykes MK, McNichol MW, Campbell EJM: Respiratory Failure , ed 2. London, Blackwell Scientific Publications, 1976. 2. Sutton J, Houston C, Mansell A, et al: Effect of acetazolamide on hypoxemia during sleep at high altitude . N Engl J Med 301:1329-1331, 1979.Crossref 3. Block AJ, Boysen PG, Wynne JW, et al: Oxygen desaturation in normal subjects . N Engl J Med 300:513-517, 1979.Crossref 4. Remmers JE, deGroot WJ, Sauerland EK, et al: Pathogenesis of upper airway occlusion during sleep . J Appl Physiol 44:931-938, 1978. 5. Phillipson EA: Respiratory adaptation in sleep . Ann Rev Physiol 40:133-156, 1978.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Sleep Hypoxemia in Patients With Cystic Fibrosis

Sleep Hypoxemia in Patients With Cystic Fibrosis

Abstract

Abstract Twovolved in the demonstration of sleep hypoxemia in patients with cystic fibrosis. First, the degrees of arterial oxygen desaturation presently shown by Francis et al (see p 734) may be great enough to accelerate the progress of cor pulmonale. Second, disturbance of the normal sleep pattern is a problem recognized by patients with advanced pulmonary disease. It certainly worsens their quality of life and may well hasten the course of the disease itself. Relationships between sleep...
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Publisher
American Medical Association
Copyright
Copyright © 1980 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1980.02130200003001
Publisher site
See Article on Publisher Site

Abstract

Abstract Twovolved in the demonstration of sleep hypoxemia in patients with cystic fibrosis. First, the degrees of arterial oxygen desaturation presently shown by Francis et al (see p 734) may be great enough to accelerate the progress of cor pulmonale. Second, disturbance of the normal sleep pattern is a problem recognized by patients with advanced pulmonary disease. It certainly worsens their quality of life and may well hasten the course of the disease itself. Relationships between sleep state and breathing are now studied with great interest by researchers in respiratory physiology, neurophysiology, and anesthesiology. New techniques allow meaningful descriptions of sleep state, activity of respiratory muscles, mechanics of breathing, and changes in arterial blood gas levels. However, the pertinent questions arose from clinical observations. Adults with severe chronic obstructive pulmonary disease have long been known to suffer reversal of the normal sleep pattern; they have increasing wakefulness at night and somnolence References 1. Sykes MK, McNichol MW, Campbell EJM: Respiratory Failure , ed 2. London, Blackwell Scientific Publications, 1976. 2. Sutton J, Houston C, Mansell A, et al: Effect of acetazolamide on hypoxemia during sleep at high altitude . N Engl J Med 301:1329-1331, 1979.Crossref 3. Block AJ, Boysen PG, Wynne JW, et al: Oxygen desaturation in normal subjects . N Engl J Med 300:513-517, 1979.Crossref 4. Remmers JE, deGroot WJ, Sauerland EK, et al: Pathogenesis of upper airway occlusion during sleep . J Appl Physiol 44:931-938, 1978. 5. Phillipson EA: Respiratory adaptation in sleep . Ann Rev Physiol 40:133-156, 1978.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Aug 1, 1980

References