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Skin Eruptions in Children Due to Probenecid

Skin Eruptions in Children Due to Probenecid Abstract This report presents a rather unusual observation of skin eruptions in children treated with the renal tubule physiologic blocking agent probenecid (p-[dipropylsulfamyl]benzoic acid). This drug has the ability, when administered with penicillin, to produce a twofold to tenfold increase in the blood penicillin level. For this reason, it seemed to us that the drug might be an ideal agent for the treatment of β-hemolytic streptococcal infections and other infections amenable to penicillin therapy. We attempted to assay its value in these infections in children. This report will be limited, however, to a discussion of the skin eruptions observed. Our observations suggest that these apparently nonserious reactions are related to the duration of treatment and to individual idiosyncrasy rather than to the dosage on an age or weight basis. Method Our studies were made during the school year 1955-1956. We used two different combinations of penicillin and probenecid; a tablet References 1. Boger, W. P., and Strickland, S. C.: Probenecid (Benemid): Its Uses and Side-Effects in 2,502 Patients , A. M. A. Arch. Int. Med. 95:83 ( (Jan.) ) 1955.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Journal of Diseases of Children American Medical Association

Skin Eruptions in Children Due to Probenecid

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Publisher
American Medical Association
Copyright
Copyright © 1957 American Medical Association. All Rights Reserved.
ISSN
0096-6916
DOI
10.1001/archpedi.1957.04030020014003
Publisher site
See Article on Publisher Site

Abstract

Abstract This report presents a rather unusual observation of skin eruptions in children treated with the renal tubule physiologic blocking agent probenecid (p-[dipropylsulfamyl]benzoic acid). This drug has the ability, when administered with penicillin, to produce a twofold to tenfold increase in the blood penicillin level. For this reason, it seemed to us that the drug might be an ideal agent for the treatment of β-hemolytic streptococcal infections and other infections amenable to penicillin therapy. We attempted to assay its value in these infections in children. This report will be limited, however, to a discussion of the skin eruptions observed. Our observations suggest that these apparently nonserious reactions are related to the duration of treatment and to individual idiosyncrasy rather than to the dosage on an age or weight basis. Method Our studies were made during the school year 1955-1956. We used two different combinations of penicillin and probenecid; a tablet References 1. Boger, W. P., and Strickland, S. C.: Probenecid (Benemid): Its Uses and Side-Effects in 2,502 Patients , A. M. A. Arch. Int. Med. 95:83 ( (Jan.) ) 1955.Crossref

Journal

A.M.A. Journal of Diseases of ChildrenAmerican Medical Association

Published: Jul 1, 1957

References