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Skin, Blood, Nerve Cells, and Heritability: New Lessons From Neurofibromatosis Type 1

Skin, Blood, Nerve Cells, and Heritability: New Lessons From Neurofibromatosis Type 1 Abstract FOR MANY years, students of the neurofibromatoses focused on the principle of neural crest origin of lesions of these disorders. It was as though characterizing them as neurocristopathies would reveal the keys to pathogenesis more quickly and more compellingly. On the other hand, these same students have learned not to be surprised by unexpected associations and correlations in neurofibromatosis type 1 (NF-1), whether at the clinical or molecular level. It turns out that the latter approach has been more fruitful. Associations that do not seem to fit at first have become more revealing as their basic biological and molecular mechanisms are now amenable to analysis. In this issue of the Archives, Zvulunov et al1 focus on one set of associations in NF-1 that has fascinated me since the late 1970s: NF-1 and its association with juvenile xanthogranuloma (JXG), juvenile chronic myelogenous leukemia (JCML), or both. See also page 904 References 1. Zvulunov A, Barak Y, Metzker A. Juvenile xanthogranuloma, neurofibromatosis, and juvenile chronic myelogenous leukemia: world statistical analysis . Arch Dermatol. 1995;131:904-908.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Skin, Blood, Nerve Cells, and Heritability: New Lessons From Neurofibromatosis Type 1

Archives of Dermatology , Volume 131 (8) – Aug 1, 1995

Skin, Blood, Nerve Cells, and Heritability: New Lessons From Neurofibromatosis Type 1

Abstract

Abstract FOR MANY years, students of the neurofibromatoses focused on the principle of neural crest origin of lesions of these disorders. It was as though characterizing them as neurocristopathies would reveal the keys to pathogenesis more quickly and more compellingly. On the other hand, these same students have learned not to be surprised by unexpected associations and correlations in neurofibromatosis type 1 (NF-1), whether at the clinical or molecular level. It turns out that the latter...
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Publisher
American Medical Association
Copyright
Copyright © 1995 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1995.01690200082015
Publisher site
See Article on Publisher Site

Abstract

Abstract FOR MANY years, students of the neurofibromatoses focused on the principle of neural crest origin of lesions of these disorders. It was as though characterizing them as neurocristopathies would reveal the keys to pathogenesis more quickly and more compellingly. On the other hand, these same students have learned not to be surprised by unexpected associations and correlations in neurofibromatosis type 1 (NF-1), whether at the clinical or molecular level. It turns out that the latter approach has been more fruitful. Associations that do not seem to fit at first have become more revealing as their basic biological and molecular mechanisms are now amenable to analysis. In this issue of the Archives, Zvulunov et al1 focus on one set of associations in NF-1 that has fascinated me since the late 1970s: NF-1 and its association with juvenile xanthogranuloma (JXG), juvenile chronic myelogenous leukemia (JCML), or both. See also page 904 References 1. Zvulunov A, Barak Y, Metzker A. Juvenile xanthogranuloma, neurofibromatosis, and juvenile chronic myelogenous leukemia: world statistical analysis . Arch Dermatol. 1995;131:904-908.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Aug 1, 1995

References