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Skin Allograft Survival in the Thymectomized, Azathioprine-Treated Adult Mongrel Dog

Skin Allograft Survival in the Thymectomized, Azathioprine-Treated Adult Mongrel Dog Abstract THE RELATION of the thymus to immunologic competence has received much attention recently. It has been shown to play an integral part in the development of the immunological system of the mouse, rat, hamster, and chicken.1,2,3 The role of the thymus in the adult animal has not been clearly defined and although thymectomy in some adults leads to a decrease in circulating lymphocytes, this is not followed by any significant impairment of immune function.1 Several investigators have postulated that the activity of an immunosuppressive drug might be potentiated by thymectomy. Starzl4 treated thymectomized, splenectomized, kidney allograft patients with azathioprine, but reported no obvious increase in survival of the grafts. This was confirmed by animal studies. Recently, however, he has urged reevaluating the value of thymectomy in preventing late rejection of kidney allografts.5 Calne6 reported no prolongation of kidney allografts in the adult thymectomized, azathioprine-treated dog. References 1. Miller, J.F.A.: The Thymus and the Development of Immunologic Responsiveness , Nature 144:1544, 1964. 2. Sherman, J.D.; Adner, M.M.; and Dameshek, W.: Effect of Thymectomy on the Golden Hamster: I. Wasting Disease , Blood 22:252, 1963. 3. 3. Graetzer, M.A., et al: Effect of Thymectomy and Bursectomy on Precipitin and Natural Hemagglutinin Production in the Chicken , J Immunology 90:878, 1963. 4. Starzl, T.E., et al: Splenectomy and Thymectomy in Human Renal Homotransplantation , Proc Soc Exp Biol Med 113:929, 1963.Crossref 5. Starzl, T.E., et al: Renal Homotransplantation: Late Function and Complication , Ann Intern Med 61:470, 1964.Crossref 6. Calne, R.Y.: Thymectomy in Dogs With Renal Homografts Treated With Drugs , Nature 199:388, 1963.Crossref 7. Information for Investigators Using Azathioprine (Imuran), Burroughs Wellcome Company, (USA) Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Skin Allograft Survival in the Thymectomized, Azathioprine-Treated Adult Mongrel Dog

Archives of Surgery , Volume 92 (3) – Mar 1, 1966

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Publisher
American Medical Association
Copyright
Copyright © 1966 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1966.01320210066012
Publisher site
See Article on Publisher Site

Abstract

Abstract THE RELATION of the thymus to immunologic competence has received much attention recently. It has been shown to play an integral part in the development of the immunological system of the mouse, rat, hamster, and chicken.1,2,3 The role of the thymus in the adult animal has not been clearly defined and although thymectomy in some adults leads to a decrease in circulating lymphocytes, this is not followed by any significant impairment of immune function.1 Several investigators have postulated that the activity of an immunosuppressive drug might be potentiated by thymectomy. Starzl4 treated thymectomized, splenectomized, kidney allograft patients with azathioprine, but reported no obvious increase in survival of the grafts. This was confirmed by animal studies. Recently, however, he has urged reevaluating the value of thymectomy in preventing late rejection of kidney allografts.5 Calne6 reported no prolongation of kidney allografts in the adult thymectomized, azathioprine-treated dog. References 1. Miller, J.F.A.: The Thymus and the Development of Immunologic Responsiveness , Nature 144:1544, 1964. 2. Sherman, J.D.; Adner, M.M.; and Dameshek, W.: Effect of Thymectomy on the Golden Hamster: I. Wasting Disease , Blood 22:252, 1963. 3. 3. Graetzer, M.A., et al: Effect of Thymectomy and Bursectomy on Precipitin and Natural Hemagglutinin Production in the Chicken , J Immunology 90:878, 1963. 4. Starzl, T.E., et al: Splenectomy and Thymectomy in Human Renal Homotransplantation , Proc Soc Exp Biol Med 113:929, 1963.Crossref 5. Starzl, T.E., et al: Renal Homotransplantation: Late Function and Complication , Ann Intern Med 61:470, 1964.Crossref 6. Calne, R.Y.: Thymectomy in Dogs With Renal Homografts Treated With Drugs , Nature 199:388, 1963.Crossref 7. Information for Investigators Using Azathioprine (Imuran), Burroughs Wellcome Company, (USA) Inc.

Journal

Archives of SurgeryAmerican Medical Association

Published: Mar 1, 1966

References