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Six-Minute Walk Test as a Prognostic Tool in Stable Coronary Heart Disease

Six-Minute Walk Test as a Prognostic Tool in Stable Coronary Heart Disease ORIGINAL INVESTIGATION Six-Minute Walk Test as a Prognostic Tool in Stable Coronary Heart Disease Data From the Heart and Soul Study Alexis L. Beatty, MD; Nelson B. Schiller, MD; Mary A. Whooley, MD Background: The prognostic value of the 6-minute walk ease severity measures (ejection fraction, inducible is- test (6MWT) in patients with stable coronary heart dis- chemia, diastolic dysfunction, amino-terminal portion of ease is unknown. We sought to determine whether the the prohormone of brain-type natriuretic peptide, and 6MWT predicted cardiovascular events in ambulatory pa- C-reactive protein), each SD decrease in 6MWT was as- tients with coronary heart disease. sociated with a 30% higher rate of cardiovascular events (hazard ratio, 1.30; 95% CI, 1.10-1.53). When added to Methods: We measured 6MWT distance and treadmill traditional risk factors, the 6MWT resulted in category- exercise capacity in 556 outpatients with stable coro- free net reclassification improvement of 39% (95% CI, nary heart disease from September 11, 2000, through De- 19%-60%). The discriminative ability of the 6MWT was cember 20, 2002. Participants were followed up for a me- similar to that of treadmill exercise capacity for predict- dian of 8.0 years for cardiovascular events (heart failure, ing cardiovascular events (C statistics http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Internal Medicine American Medical Association

Six-Minute Walk Test as a Prognostic Tool in Stable Coronary Heart Disease

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Publisher
American Medical Association
Copyright
Copyright 2012 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6106
eISSN
2168-6114
DOI
10.1001/archinternmed.2012.2198
pmid
22710902
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL INVESTIGATION Six-Minute Walk Test as a Prognostic Tool in Stable Coronary Heart Disease Data From the Heart and Soul Study Alexis L. Beatty, MD; Nelson B. Schiller, MD; Mary A. Whooley, MD Background: The prognostic value of the 6-minute walk ease severity measures (ejection fraction, inducible is- test (6MWT) in patients with stable coronary heart dis- chemia, diastolic dysfunction, amino-terminal portion of ease is unknown. We sought to determine whether the the prohormone of brain-type natriuretic peptide, and 6MWT predicted cardiovascular events in ambulatory pa- C-reactive protein), each SD decrease in 6MWT was as- tients with coronary heart disease. sociated with a 30% higher rate of cardiovascular events (hazard ratio, 1.30; 95% CI, 1.10-1.53). When added to Methods: We measured 6MWT distance and treadmill traditional risk factors, the 6MWT resulted in category- exercise capacity in 556 outpatients with stable coro- free net reclassification improvement of 39% (95% CI, nary heart disease from September 11, 2000, through De- 19%-60%). The discriminative ability of the 6MWT was cember 20, 2002. Participants were followed up for a me- similar to that of treadmill exercise capacity for predict- dian of 8.0 years for cardiovascular events (heart failure, ing cardiovascular events (C statistics

Journal

JAMA Internal MedicineAmerican Medical Association

Published: Jul 23, 2012

References