Abstract • A 17-year-old girl with right-sided epiphora and a lacrimal sac mass was found radiologically to have marked enlargement of her lacrimal sac and nasolacrimal duct and mucosal thickening of her right nasal turbinates and maxillary, ethmoid, and sphenoid sinuses. Biopsy specimens from all these sites showed chronic inflammatory infiltrates with a predominant population of large phagocytic histiocytes, some of which had engulfed lymphocytes and plasmacytes. The results of a systemic workup were normal. This is the first reported case, to our knowledge, of sinus histiocytosis involving the lacrimal sac and nasolacrimal duct as an extranodal focus. References 1. Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy: a newly recognized benign clinicopathological entity . Arch Pathol Lab Med . 1969;87:63-70. 2. Foucar E, Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy: ear, nose and throat manifestations . Arch Otolaryngol Head Neck Surg . 1978;104:687-693.Crossref 3. Foucar E, Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy: an analysis of 14 deaths occurring in a patient registry . Cancer . 1984;54:1834-1840.Crossref 4. Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy: a pseudolymphomatous benign disorder . Cancer . 1972;30:1174-1188.Crossref 5. Friendly DS, Font RL, Rao NA. Orbital involvement in 'sinus' histiocytosis: a report of four cases . Arch Ophthalmol . 1977;95:2006-2011.Crossref 6. Thawerani H, Sanchez RL, Rosai J, Dorfman RF. The cutaneous manifestations of sinus histiocytosis with massive lymphadenopathy . Arch Dermatol . 1978;114:191-197.Crossref 7. Gonzales CL, Jaffe ES. The histiocytoses: clinical presentation and differential diagnosis . Oncology . 1990;4:47-62. 8. Sanchez R, Sibley RK, Rosai J, Dorfman RF. The electron microscopic features of sinus histiocytosis with massive lymphadenopathy . Ultrastruct Pathol . 1981;2:101-119.Crossref 9. Ngendahayo P, Roels H, Quatacker J, Boddaert J, Ntabomuvra V, Mbonyingabo P. Sinus histiocytosis with massive lymphadenopathy in Rwanda: report of eight cases with immunohistochemical and ultrastructural studies . Histopathology . 1983;7:49-63.Crossref 10. Marion JR, Geisinger KR. Sinus histiocytosis with massive lymphadenopathy: bilateral orbital involvement spanning 17 years . Ann Ophthalmol . 1989;21:55-58. 11. Foucar E, Rosai J, Dorfman RF. The ophthalmologic manifestations of sinus histiocytosis with massive lymphadenopathy . Am J Ophthalmol . 1979;87:354-367. 12. Pickering LK, Phelan E. Sinus histiocytosis . J Pediatr . 1975;86:745-748.Crossref 13. Stopak SS, Dreizen NG, Zimmerman LE, O'Neill JF. Sinus histiocytosis presenting as an epibulbar mass: a clinicopathologic case report . Arch Ophthalmol . 1988;106:1426-1428.Crossref 14. Codling BW, Soni KC, Barry DR, Martin-Walker W. Histiocytosis presenting as a swelling of the orbit and eyelid . Br J Ophthalmol . 1972;56:517-530.Crossref
Archives of Ophthalmology – American Medical Association
Published: Nov 1, 1991
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