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Similar Ro/SS-A Autoantibody Epitope and Titer Responses in Annular Erythema of Sjögren's Syndrome and Subacute Cutaneous Lupus Erythematosus

Similar Ro/SS-A Autoantibody Epitope and Titer Responses in Annular Erythema of Sjögren's... Abstract Background and Design: Studies were conducted to determine whether certain types of Ro autoantibodies are unique to subacute cutaneous lupus erythematosus and annular erythema of Sjögren's syndrome. Ten American subacute cutaneous lupus erythematosus sera, 11 Japanese annular erythema of Sjögren's syndrome sera, and 39 control sera were tested by enzyme-linked immunosorbent assay with recombinant 52- and 60-kd Ro fusion proteins, native 60-kd Ro protein, and native La/ SS-B protein. Results: Japanese annular erythema of Sjögren's syndrome sera and American subacute cutaneous lupus erythematosus sera share several types of anti-52-kd and anti-60-kd Ro autoantibodies. However, these antibodies were found significantly more often and in significantly higher titers in sera from patients with Sjögren's syndrome who did not manifest these skin diseases. Patients with high Ro autoantibody titers were likely to have overt exocrine gland dysfunction. Conclusions: The failure to identify disease-specific Ro autoantibodies in subacute cutaneous lupus erythematosus and annular erythema of Sjögren's syndrome sera suggests that additional factors influence the development of these skin diseases. However, similarities in the Ro autoantibody responses and in the clinical features of subacute cutaneous lupus erythematosus and annular erythema of Sjögren's syndrome suggest that these two skin diseases might arise from a similar pathogenic process.(Arch Dermatol. 1996;132:528-531) References 1. McCauliffe DP. Neonatal lupus erythematosus: a transplacentally acquired autoimmune disorder . Semin Dermatol. 1995;14:47-53.Crossref 2. Lee LA, Weston WL. New findings in neonatal lupus syndrome . AJDC. 1984; 138:233-236. 3. Lee LA, Gaither KK, Coulter SN, Norris DA, Harley JB. Pattern of cutaneous immunoglobulin G deposits in subacute cutaneous lupus erythematosus is reproduced by infusing purified anti-Ro(SSA) autoantibodies into human skin-grafted mice . J Clin Invest. 1989;83:1556-1562.Crossref 4. LeFeber WP, Norris DA, Ryan SR, et al. Ultraviolet light induces binding of antibodies to selected nuclear antigens on cultured human keratinocytes . J Clin Invest. 1984;74:1545-1551.Crossref 5. Furukawa F, Kashihara-Sawami M, Lyons MB, Norris DA. Binding of antibodies to ENA SS-A/Ro and SS-B/La is induced on the surface of human keratinocytes by UVL: implications for the pathogenesis of photosensitive cutaneous lupus . J Invest Dermatol. 1990;94:77-85.Crossref 6. Valeski JE, Kumar V, Forman AB, Beutner EH, Chorzelski TP. A characteristic cutaneous direct immunofluorescent pattern associated with Ro(SS-A) antibodies in subacute cutaneous lupus erythematosus . J Am Acad Dermatol. 1992;27:194-198.Crossref 7. Provost TT, Talal N, Harley JB, Reichlin M, Alexander E. The relationship between anti-Ro (SS-A) antibody-positive Sjögren's syndrome and anti-Ro (SS-A) antibody-positive lupus erythematosus . Arch Dermatol. 1988;124:63-71.Crossref 8. Nishikawa T, Provost TT. Differences in clinical, serologic, and immunogenetic features of white versus Oriental anti-SS-A/Ro-positive patients . J Am Acad Dermatol. 1991;25:563-564.Crossref 9. Katayama I, Teramoto N, Arai H, Nishioka K, Nishiyama S. Annular erythema: a comparative study of Sjögren syndrome with subacute cutaneous lupus erythematosus . Int J Dermatol. 1991;30:635-639.Crossref 10. Nishikawa T, Hoshino Y. Annular erythema in Sjögren's syndrome . In: Homma M, Sugai S, Tojo T, Miyasaka N, Akizuki M, eds. Proceedings of the Fourth International Symposiumon Sjögren's Syndrome . New York, NY: Kugler Publications; 1993:151-153. 11. Lee LA. Neonatal lupus erythematosus . J Invest Dermatol. 1993;100( (suppl) ):9S-13S.Crossref 12. Kaneko F, Tanji O, Hasegawa T, Ohto H, Yamazaki K. Neonatal lupus erythematosus in Japan . J Am Acad Dermatol. 1992;26:397-403.Crossref 13. Homma M, Tojo T, Akizuki M, Yamagata H. Criteria for Sjögren,s syndrome in Japan . Scand J Rheumatol Suppl. 1986;61:26-27. 14. McCauliffe DP, Yin H, Wang L, Lucas L. Autoimmune sera react with multiple epitopes on recombinant 52 and 60 kDa Ro(SSA) proteins . J Rheumatol. 1994; 21:1073-1080. 15. Hamilton RG, Adkinson NF Jr. Quantitative aspects of solid phase immunoassays . In: Kemeny M, Challacombe SJ, eds. Theoretical and Technical Aspects of ELISA and Other Solid Phase Assays . New York, NY: John Wiley & Sons Inc; 1988:57-84. 16. David-Bajar KM, Bennion SD, DeSpain JD, Golitz LE, Lee LA. Clinical, histologic, and immunofluorescent distinctions between subactute cutaneous lupus erythematosus and discoid lupus erythematosus . J Invest Dermatol. 1992;99:251-257.Crossref 17. Lee LA, Frank MB, McCubbin VR, Reichlin M. Autoantibodies of neonatal lupus erythematosus . J Invest Dermatol. 1994;102:963-966.Crossref 18. Jacobsson L, Hansen BU, Manthorpe R, Hardgrave K, Neas B, Harley JB. Association of dry eyes and dry mouth with anti-Ro/SS-A and anti-La/SS-B autoantibodies in normal adults . Arthritis Rheum. 1992;35:1492-1500.Crossref 19. Tsuzaka K, Ogasawara T, Tojo T, Fujii H, Tsukatani Y, Homma M. Relationship between autoantibodies and clinical parameters in Sjögren's syndrome . Scand J Rheumatol. 1995;22:1-9.Crossref 20. Fossaluzza V, De Vita S. Clinical differences between ANA/anti-ENA positive or negative primary Sjögren's syndrome . Clin Rheumatol. 1992;11:385-387.Crossref 21. Hoshino Y, Hashimoto T, Mimori T, Akizuki M, Nishikawa T. Recurrent annular erythema associated with anti-SS-B/La antibodies: analysis of the disease-specific epitope . Br J Dermatol. 1992;127:608-613.Crossref 22. Watson RM, Scheel JN, Petri M, et al. Neonatal lupus erythematosus. Report of serological and immunogenetic studies in ywins discordant for congenital heart block . Br J Dermatol. 1994;130:342-348.Crossref 23. Callen JP, Fowler JF, Kulick KB, Stelzer G, Smith SZ. Neonatal lupus erythematosus occurring in one fraternal twin . Arthritis Rheum. 1985;28:271-275.Crossref 24. Niimi Y, Loannides D, Buyon J, Bystryn JC. Heterogeneity in the expression of Ro and La antigens in human skin . Arthritis Rheum. 1995;38:1271-1276.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Similar Ro/SS-A Autoantibody Epitope and Titer Responses in Annular Erythema of Sjögren's Syndrome and Subacute Cutaneous Lupus Erythematosus

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Publisher
American Medical Association
Copyright
Copyright © 1996 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1996.03890290062008
Publisher site
See Article on Publisher Site

Abstract

Abstract Background and Design: Studies were conducted to determine whether certain types of Ro autoantibodies are unique to subacute cutaneous lupus erythematosus and annular erythema of Sjögren's syndrome. Ten American subacute cutaneous lupus erythematosus sera, 11 Japanese annular erythema of Sjögren's syndrome sera, and 39 control sera were tested by enzyme-linked immunosorbent assay with recombinant 52- and 60-kd Ro fusion proteins, native 60-kd Ro protein, and native La/ SS-B protein. Results: Japanese annular erythema of Sjögren's syndrome sera and American subacute cutaneous lupus erythematosus sera share several types of anti-52-kd and anti-60-kd Ro autoantibodies. However, these antibodies were found significantly more often and in significantly higher titers in sera from patients with Sjögren's syndrome who did not manifest these skin diseases. Patients with high Ro autoantibody titers were likely to have overt exocrine gland dysfunction. Conclusions: The failure to identify disease-specific Ro autoantibodies in subacute cutaneous lupus erythematosus and annular erythema of Sjögren's syndrome sera suggests that additional factors influence the development of these skin diseases. However, similarities in the Ro autoantibody responses and in the clinical features of subacute cutaneous lupus erythematosus and annular erythema of Sjögren's syndrome suggest that these two skin diseases might arise from a similar pathogenic process.(Arch Dermatol. 1996;132:528-531) References 1. McCauliffe DP. Neonatal lupus erythematosus: a transplacentally acquired autoimmune disorder . Semin Dermatol. 1995;14:47-53.Crossref 2. Lee LA, Weston WL. New findings in neonatal lupus syndrome . AJDC. 1984; 138:233-236. 3. Lee LA, Gaither KK, Coulter SN, Norris DA, Harley JB. Pattern of cutaneous immunoglobulin G deposits in subacute cutaneous lupus erythematosus is reproduced by infusing purified anti-Ro(SSA) autoantibodies into human skin-grafted mice . J Clin Invest. 1989;83:1556-1562.Crossref 4. LeFeber WP, Norris DA, Ryan SR, et al. Ultraviolet light induces binding of antibodies to selected nuclear antigens on cultured human keratinocytes . J Clin Invest. 1984;74:1545-1551.Crossref 5. Furukawa F, Kashihara-Sawami M, Lyons MB, Norris DA. Binding of antibodies to ENA SS-A/Ro and SS-B/La is induced on the surface of human keratinocytes by UVL: implications for the pathogenesis of photosensitive cutaneous lupus . J Invest Dermatol. 1990;94:77-85.Crossref 6. Valeski JE, Kumar V, Forman AB, Beutner EH, Chorzelski TP. A characteristic cutaneous direct immunofluorescent pattern associated with Ro(SS-A) antibodies in subacute cutaneous lupus erythematosus . J Am Acad Dermatol. 1992;27:194-198.Crossref 7. Provost TT, Talal N, Harley JB, Reichlin M, Alexander E. The relationship between anti-Ro (SS-A) antibody-positive Sjögren's syndrome and anti-Ro (SS-A) antibody-positive lupus erythematosus . Arch Dermatol. 1988;124:63-71.Crossref 8. Nishikawa T, Provost TT. Differences in clinical, serologic, and immunogenetic features of white versus Oriental anti-SS-A/Ro-positive patients . J Am Acad Dermatol. 1991;25:563-564.Crossref 9. Katayama I, Teramoto N, Arai H, Nishioka K, Nishiyama S. Annular erythema: a comparative study of Sjögren syndrome with subacute cutaneous lupus erythematosus . Int J Dermatol. 1991;30:635-639.Crossref 10. Nishikawa T, Hoshino Y. Annular erythema in Sjögren's syndrome . In: Homma M, Sugai S, Tojo T, Miyasaka N, Akizuki M, eds. Proceedings of the Fourth International Symposiumon Sjögren's Syndrome . New York, NY: Kugler Publications; 1993:151-153. 11. Lee LA. Neonatal lupus erythematosus . J Invest Dermatol. 1993;100( (suppl) ):9S-13S.Crossref 12. Kaneko F, Tanji O, Hasegawa T, Ohto H, Yamazaki K. Neonatal lupus erythematosus in Japan . J Am Acad Dermatol. 1992;26:397-403.Crossref 13. Homma M, Tojo T, Akizuki M, Yamagata H. Criteria for Sjögren,s syndrome in Japan . Scand J Rheumatol Suppl. 1986;61:26-27. 14. McCauliffe DP, Yin H, Wang L, Lucas L. Autoimmune sera react with multiple epitopes on recombinant 52 and 60 kDa Ro(SSA) proteins . J Rheumatol. 1994; 21:1073-1080. 15. Hamilton RG, Adkinson NF Jr. Quantitative aspects of solid phase immunoassays . In: Kemeny M, Challacombe SJ, eds. Theoretical and Technical Aspects of ELISA and Other Solid Phase Assays . New York, NY: John Wiley & Sons Inc; 1988:57-84. 16. David-Bajar KM, Bennion SD, DeSpain JD, Golitz LE, Lee LA. Clinical, histologic, and immunofluorescent distinctions between subactute cutaneous lupus erythematosus and discoid lupus erythematosus . J Invest Dermatol. 1992;99:251-257.Crossref 17. Lee LA, Frank MB, McCubbin VR, Reichlin M. Autoantibodies of neonatal lupus erythematosus . J Invest Dermatol. 1994;102:963-966.Crossref 18. Jacobsson L, Hansen BU, Manthorpe R, Hardgrave K, Neas B, Harley JB. Association of dry eyes and dry mouth with anti-Ro/SS-A and anti-La/SS-B autoantibodies in normal adults . Arthritis Rheum. 1992;35:1492-1500.Crossref 19. Tsuzaka K, Ogasawara T, Tojo T, Fujii H, Tsukatani Y, Homma M. Relationship between autoantibodies and clinical parameters in Sjögren's syndrome . Scand J Rheumatol. 1995;22:1-9.Crossref 20. Fossaluzza V, De Vita S. Clinical differences between ANA/anti-ENA positive or negative primary Sjögren's syndrome . Clin Rheumatol. 1992;11:385-387.Crossref 21. Hoshino Y, Hashimoto T, Mimori T, Akizuki M, Nishikawa T. Recurrent annular erythema associated with anti-SS-B/La antibodies: analysis of the disease-specific epitope . Br J Dermatol. 1992;127:608-613.Crossref 22. Watson RM, Scheel JN, Petri M, et al. Neonatal lupus erythematosus. Report of serological and immunogenetic studies in ywins discordant for congenital heart block . Br J Dermatol. 1994;130:342-348.Crossref 23. Callen JP, Fowler JF, Kulick KB, Stelzer G, Smith SZ. Neonatal lupus erythematosus occurring in one fraternal twin . Arthritis Rheum. 1985;28:271-275.Crossref 24. Niimi Y, Loannides D, Buyon J, Bystryn JC. Heterogeneity in the expression of Ro and La antigens in human skin . Arthritis Rheum. 1995;38:1271-1276.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: May 1, 1996

References