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Sickle-Cell Hemoglobin and Its Relation to Fundus Abnormality

Sickle-Cell Hemoglobin and Its Relation to Fundus Abnormality Abstract In 1956 Hannon1 presented a classic paper entitled Vitreous Hemorrhages Associated With Sickle Cell Hemoglobin C Disease. He stated "the peculiar retinopathy and vitreous hemorrhage occurs almost always in the sickle cell hemoglobin C variety." In 1957 Kennedy and Cope2 reported a case of a patient with sickle-cell trait who had had a vitreous hemorrhage, and in 1958 Isbey et al3 added four others. In 1959 Lieb and associates4 presented a paper on sickle-cell retinopathy in which they stated "according to our findings, patients with SS hemoglobin in general give evidence of similar ocular pathology to those with sickle-cell hemoglobin C diseases. Patients with SA demonstrate minor fundus changes or none at all." In light of these reports, this subject assumes certain conflicting and controversial aspects. It is because of this that the present study was undertaken in an attempt to clarify the relationship of sickle References 1. Hannon, J.F.: Vitreous Hemorrhages Associated With Sickle Cell Hemoglobin C Disease , Amer J Ophthal 42:707, 1956. 2. Kennedy, J.J., and Cope, C.B.: Intraocular Lesions Associated With Sickle Cell Disease , Arch Ophthal 58:163, 1957.Crossref 3. Isbey, E.K.; Clifford, G.O.; and Tanaka, K.R.: Vitreous Hemorrhage Associated With Sickle Cell Trait and Sickle Cell Hemoglobin C Disease , Amer J Opthal 45:870, 1958. 4. Lieb, W.A.; Geeraets, W.J.; and Guerry, D.: Sickle Cell Retinopathy , Acta Ophthal , (suppl 58) , pp 1-45, 1959. 5. Herrick, J.B.: Peculiar Elongated and Sickle-Shaped Red Corpuscles in a Case of Severe Anemia , Arch Intern Med 6:517, 1910.Crossref 6. Taliaferro, W.H., and Huck, J.G.: The Inheritance of Sickle Cell Anemia in Man , Genetics 8:594, 1923. 7. Neel, J.V.: The Inheritance of Sickle Cell Anemia , Science 110:64, 1949.Crossref 8. Pauling, L. et al: Sickle Cell Anemia, a Molecular Disease , Science 110:543, 1949.Crossref 9. Baglioni, C.: Abnormal Human Hemoglobins VIII , Biochim Biophys Acta 59:437, 1962.Crossref 10. Ingram, V.M.: The Hemoglobins in Genetics and Evolution . New York: Columbia University Press, 1963. 11. Myersoson, R.M.; Harrison, E.; and Lohmuller, H. W.: Incidence and Significance of Abnormal Hemoglobins , Amer J Med 26:543, 1959.Crossref 12. Cook, W.C.: A Case of Sickle Cell Anemia With Associated Subarachnoid Hemorrhage , Amer J Med 11:541, 1930. 13. Harden, A.S., Jr.: Sickle Cell Anemia: Changes in the Vessels and in the Bones , Amer J Dis Child 54:1045, 1937.Crossref 14. Klinefelter, H.F.: The Heart in Sickle Cell Anemia , Amer J Med Sci 208:34, 1942.Crossref 15. Ray, E.S., and Cecil, R.C.: Infectious Mononucleosis in the Negro: Report on Three Cases With One Complicated by Sickle Cell Anemia , Southern Med J 34:543, 1944.Crossref 16. Edington, G.M., and Sarkies, J.W.R.: Two Cases of Sickle Cell Anemia Associated With Retinal Lesions , Trans Roy Soc Trop Med Hyg 46:59, 1952.Crossref 17. Henry, M.D., and Chapman, A.Z.: Vitreous Hemorrhage and Retinopathy Associated With Sickle Cell Disease , Amer J Ophthal 34:204, 1954. 18. Smith, E.W., and Conley, C.L.: Clinical Features of the Genetic Variants of Sickle Cell Disease , Bull Hopkins Hosp 94:289, 1954. 19. Paton, D.: The Conjunctival Sign of Sickle Cell Disease , Arch Ophthal 68:627, 1962.Crossref 20. Levine, R.A., and Kaplan, A.M.: The Ophthalmoscopic Findings in C + S Disease , Amer J Ophthal 59:37, 1965. 21. Goodman, G.; von Sallmann, L.; and Holland, M.C.: Ocular Manifestations of Sickle Cell Disease , Arch Ophthal 58:655, 1957.Crossref 22. Munro, S., and Walker, C.: Ocular Complications in Sickle Cell Hemoglobin C Disease , Brit J Ophthal 44:1, 1960.Crossref 23. Smith, E.W., and Conley, C.L.: Sicklemia and Infarction of the Spleen During Aerial Flight , Bull Hopkins Hosp 96:35, 1955. 24. Kabakow, B.; von Wiemokly, S.; and Lyons, H.: Bilateral Central Retinal Artery Occlusion , Arch Ophthal 54:670, 1955.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Sickle-Cell Hemoglobin and Its Relation to Fundus Abnormality

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Publisher
American Medical Association
Copyright
Copyright © 1966 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1966.00970050355008
Publisher site
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Abstract

Abstract In 1956 Hannon1 presented a classic paper entitled Vitreous Hemorrhages Associated With Sickle Cell Hemoglobin C Disease. He stated "the peculiar retinopathy and vitreous hemorrhage occurs almost always in the sickle cell hemoglobin C variety." In 1957 Kennedy and Cope2 reported a case of a patient with sickle-cell trait who had had a vitreous hemorrhage, and in 1958 Isbey et al3 added four others. In 1959 Lieb and associates4 presented a paper on sickle-cell retinopathy in which they stated "according to our findings, patients with SS hemoglobin in general give evidence of similar ocular pathology to those with sickle-cell hemoglobin C diseases. Patients with SA demonstrate minor fundus changes or none at all." In light of these reports, this subject assumes certain conflicting and controversial aspects. It is because of this that the present study was undertaken in an attempt to clarify the relationship of sickle References 1. Hannon, J.F.: Vitreous Hemorrhages Associated With Sickle Cell Hemoglobin C Disease , Amer J Ophthal 42:707, 1956. 2. Kennedy, J.J., and Cope, C.B.: Intraocular Lesions Associated With Sickle Cell Disease , Arch Ophthal 58:163, 1957.Crossref 3. Isbey, E.K.; Clifford, G.O.; and Tanaka, K.R.: Vitreous Hemorrhage Associated With Sickle Cell Trait and Sickle Cell Hemoglobin C Disease , Amer J Opthal 45:870, 1958. 4. Lieb, W.A.; Geeraets, W.J.; and Guerry, D.: Sickle Cell Retinopathy , Acta Ophthal , (suppl 58) , pp 1-45, 1959. 5. Herrick, J.B.: Peculiar Elongated and Sickle-Shaped Red Corpuscles in a Case of Severe Anemia , Arch Intern Med 6:517, 1910.Crossref 6. Taliaferro, W.H., and Huck, J.G.: The Inheritance of Sickle Cell Anemia in Man , Genetics 8:594, 1923. 7. Neel, J.V.: The Inheritance of Sickle Cell Anemia , Science 110:64, 1949.Crossref 8. Pauling, L. et al: Sickle Cell Anemia, a Molecular Disease , Science 110:543, 1949.Crossref 9. Baglioni, C.: Abnormal Human Hemoglobins VIII , Biochim Biophys Acta 59:437, 1962.Crossref 10. Ingram, V.M.: The Hemoglobins in Genetics and Evolution . New York: Columbia University Press, 1963. 11. Myersoson, R.M.; Harrison, E.; and Lohmuller, H. W.: Incidence and Significance of Abnormal Hemoglobins , Amer J Med 26:543, 1959.Crossref 12. Cook, W.C.: A Case of Sickle Cell Anemia With Associated Subarachnoid Hemorrhage , Amer J Med 11:541, 1930. 13. Harden, A.S., Jr.: Sickle Cell Anemia: Changes in the Vessels and in the Bones , Amer J Dis Child 54:1045, 1937.Crossref 14. Klinefelter, H.F.: The Heart in Sickle Cell Anemia , Amer J Med Sci 208:34, 1942.Crossref 15. Ray, E.S., and Cecil, R.C.: Infectious Mononucleosis in the Negro: Report on Three Cases With One Complicated by Sickle Cell Anemia , Southern Med J 34:543, 1944.Crossref 16. Edington, G.M., and Sarkies, J.W.R.: Two Cases of Sickle Cell Anemia Associated With Retinal Lesions , Trans Roy Soc Trop Med Hyg 46:59, 1952.Crossref 17. Henry, M.D., and Chapman, A.Z.: Vitreous Hemorrhage and Retinopathy Associated With Sickle Cell Disease , Amer J Ophthal 34:204, 1954. 18. Smith, E.W., and Conley, C.L.: Clinical Features of the Genetic Variants of Sickle Cell Disease , Bull Hopkins Hosp 94:289, 1954. 19. Paton, D.: The Conjunctival Sign of Sickle Cell Disease , Arch Ophthal 68:627, 1962.Crossref 20. Levine, R.A., and Kaplan, A.M.: The Ophthalmoscopic Findings in C + S Disease , Amer J Ophthal 59:37, 1965. 21. Goodman, G.; von Sallmann, L.; and Holland, M.C.: Ocular Manifestations of Sickle Cell Disease , Arch Ophthal 58:655, 1957.Crossref 22. Munro, S., and Walker, C.: Ocular Complications in Sickle Cell Hemoglobin C Disease , Brit J Ophthal 44:1, 1960.Crossref 23. Smith, E.W., and Conley, C.L.: Sicklemia and Infarction of the Spleen During Aerial Flight , Bull Hopkins Hosp 96:35, 1955. 24. Kabakow, B.; von Wiemokly, S.; and Lyons, H.: Bilateral Central Retinal Artery Occlusion , Arch Ophthal 54:670, 1955.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Mar 1, 1966

References

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