COMMENTARY S MELATONIN a new inroad leagues, failed to demonstrate a sponse Shamir and coauthors actu- into the treatment and un- treatment effect for vitamin E on TD. ally found with melatonin. In our derstanding of the patho- Since melatonin is a more potent clinical and research experience, a re- physiologic characteris- antioxidant agent than vitamin E, it duction of 2.45 points on a scale that I tics of tardive dyskinesia is certainly worth studying in its ranges from 0 to 28 is usually not a (TD), or is it just another boulder own right. However, results from a very robust response from a treat- in the Sisyphean history of treat- previous placebo-controlled trial ment perspective, unless the patient ments for iatrogenic conditions? In with the highly potent antioxidant has only one anatomic area affected. this issue of the ARCHIVES, Shamir L-deprenyl were also negative. Furthermore, 9 of 22 patients in the et al report the effectiveness of a What can we learn from the dis- study by Shamir and colleagues ex- 6-week trial of melatonin, 10 mg/d, appointing history of vitamin E, and hibited a reduction of 30% or more relative to placebo in 22 patients. how does
JAMA Psychiatry – American Medical Association
Published: Nov 1, 2001
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