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Short-term Effects of Unilateral 1% Apraclonidine Therapy

Short-term Effects of Unilateral 1% Apraclonidine Therapy Abstract • A prospective, double-masked, randomized study evaluated the effects of unilateral therapy with topical 1% apraclonidine hydrochloride (aplonidine hydrochloride or ALO 2145) in 20 normal volunteers. No medications were applied to either eye during the control day. Following baseline measurements on the day of treatment, one drop of topical 1% apraclonidine hydrochloride was placed on one eye and a placebo (vehicle) was placed on the fellow eye. Intraocular pressure (IOP) measurements, pupil size, blood pressure, and pulse rate were assessed on both days at the baseline and 1, 3, 5, and 7 hours later. The 1% apraclonidine hydrochloride lowered the mean IOP ( ± SD) a maximum of 6.5 ± 4.3 mm Hg (37.3% ± 20.4%) from the baseline on the day of treatment. A statistically significant 2.7 ± 3.4-mm Hg (14.9% ± 19.0%) mean IOP decrease from the baseline was noted in the contralateral placebo-treated eye. No significant changes in the coefficient of outflow, blood pressure, or heart rate were noted. Eyelid retraction, conjunctival blanching, and mydriasis were frequently noted in eyes treated with 1% apraclonidine hydrochloride. References 1. Harrison R, Kaufmann CS: Clonidine: Effects of a topically administered solution on intraocular pressure and blood pressure in openangle glaucoma . Arch Ophthalmol 1977;95:1368-1373.Crossref 2. Petursson G, Cole R, Hanna C: Treatment of glaucoma using minidrops of clonidine . Arch Ophthalmol 1984;102:1180-1181.Crossref 3. Hodapp E, Kolker AE, Kass MA, et al: The effect of topical clonidine on intraocular pressure . Arch Ophthalmol 1981;99:1208-1211.Crossref 4. Lee DA, Topper JE, Brubaker RF: Effect of clonidine on aqueous humor flow in normal human eyes . Exp Eye Res 1984;38:239-246.Crossref 5. Innemee HC, van Zweiten PA: The distribution in the eye and the effect on intraocular pressure of clonidine . Graefes Arch Ophthalmol 1979;209:189-198.Crossref 6. Liu JHK, Neufeld AH: Study of central regulation of intraocular pressure using ventriculocisternal perfusion . Invest Ophthalmol Vis Sci 1985;26:136-143. 7. Innemee HC, Hermans AJM, van Zweiten PA: The influence of clonidine on intraocular pressure after topical application to the eyes of anesthetized cats . Graefes Arch Ophthalmol 1979;212:19-27.Crossref 8. Krieglstein GK, Langham ME, Leydhecker W: The peripheral and central neural actions of clonidine in normal and glaucomatous eyes . Invest Ophthalmol Vis Sci 1978;17:149-158. 9. Innemee HC, van Zweiten PA: The central ocular hypotensive effect of clonidine . Graefes Arch Ophthalmol 1979;210:93-102.Crossref 10. Abrams DA, Robin AL, Pollack IP, et al: The safety and efficacy of topical 1% ALO 2145 (p-aminoclonidine hydrochloride) in normal volunteers . Arch Ophthalmol 1987;105:1205-1207.Crossref 11. Robin AL, Pollack IP, House B, et al: Effects of ALO 2145 on intraocular pressure following argon laser trabeculoplasty . Arch Ophthalmol 1987;105:646-650.Crossref 12. Robin AL, Pollack IP, deFaller JM: Effects of topical ALO 2145 (p-aminoclonidine hydrochloride) on the acute intraocular pressure rise after argon laser iridotomy . Arch Ophthalmol 1987;105:1208-1211.Crossref 13. Shin DH: Bilateral effects of monocular timolol treatment . Am J Ophthalmol 1986;102:275-276.Crossref 14. Smith J, Wandel T: Rationale for the one-eye therapeutic trial . Ann Ophthalmol 1986;18:8. 15. Hernandez Y, Hernandez H, Cervantes R, et al: Cardiovascular effects of topical glaucoma therapies in normal subjects . Cutan Ocular Toxicol 1983;2:99-106.Crossref 16. Allen RC, Langham ME: The intraocular pressure response of conscious rabbits to clonidine . Invest Ophthalmol Vis Sci 1976;15:815-823. 17. Gay AJ, Wolkstein MA: Topical guanethidine therapy for endocrine lid retraction . Arch Ophthalmol 1966;76:364-367.Crossref 18. Ralli R: Clonidine effect on the intraocular pressure and eye circulation . Acta Ophthalmol 1975;125:37. 19. Bill A, Heilmann K: Ocular effects of clonidine in cats and monkeys (Macaca irus) . Exp Eye Res 1975;21:481-488.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Short-term Effects of Unilateral 1% Apraclonidine Therapy

Archives of Ophthalmology , Volume 106 (7) – Jul 1, 1988

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Publisher
American Medical Association
Copyright
Copyright © 1988 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1988.01060140058024
Publisher site
See Article on Publisher Site

Abstract

Abstract • A prospective, double-masked, randomized study evaluated the effects of unilateral therapy with topical 1% apraclonidine hydrochloride (aplonidine hydrochloride or ALO 2145) in 20 normal volunteers. No medications were applied to either eye during the control day. Following baseline measurements on the day of treatment, one drop of topical 1% apraclonidine hydrochloride was placed on one eye and a placebo (vehicle) was placed on the fellow eye. Intraocular pressure (IOP) measurements, pupil size, blood pressure, and pulse rate were assessed on both days at the baseline and 1, 3, 5, and 7 hours later. The 1% apraclonidine hydrochloride lowered the mean IOP ( ± SD) a maximum of 6.5 ± 4.3 mm Hg (37.3% ± 20.4%) from the baseline on the day of treatment. A statistically significant 2.7 ± 3.4-mm Hg (14.9% ± 19.0%) mean IOP decrease from the baseline was noted in the contralateral placebo-treated eye. No significant changes in the coefficient of outflow, blood pressure, or heart rate were noted. Eyelid retraction, conjunctival blanching, and mydriasis were frequently noted in eyes treated with 1% apraclonidine hydrochloride. References 1. Harrison R, Kaufmann CS: Clonidine: Effects of a topically administered solution on intraocular pressure and blood pressure in openangle glaucoma . Arch Ophthalmol 1977;95:1368-1373.Crossref 2. Petursson G, Cole R, Hanna C: Treatment of glaucoma using minidrops of clonidine . Arch Ophthalmol 1984;102:1180-1181.Crossref 3. Hodapp E, Kolker AE, Kass MA, et al: The effect of topical clonidine on intraocular pressure . Arch Ophthalmol 1981;99:1208-1211.Crossref 4. Lee DA, Topper JE, Brubaker RF: Effect of clonidine on aqueous humor flow in normal human eyes . Exp Eye Res 1984;38:239-246.Crossref 5. Innemee HC, van Zweiten PA: The distribution in the eye and the effect on intraocular pressure of clonidine . Graefes Arch Ophthalmol 1979;209:189-198.Crossref 6. Liu JHK, Neufeld AH: Study of central regulation of intraocular pressure using ventriculocisternal perfusion . Invest Ophthalmol Vis Sci 1985;26:136-143. 7. Innemee HC, Hermans AJM, van Zweiten PA: The influence of clonidine on intraocular pressure after topical application to the eyes of anesthetized cats . Graefes Arch Ophthalmol 1979;212:19-27.Crossref 8. Krieglstein GK, Langham ME, Leydhecker W: The peripheral and central neural actions of clonidine in normal and glaucomatous eyes . Invest Ophthalmol Vis Sci 1978;17:149-158. 9. Innemee HC, van Zweiten PA: The central ocular hypotensive effect of clonidine . Graefes Arch Ophthalmol 1979;210:93-102.Crossref 10. Abrams DA, Robin AL, Pollack IP, et al: The safety and efficacy of topical 1% ALO 2145 (p-aminoclonidine hydrochloride) in normal volunteers . Arch Ophthalmol 1987;105:1205-1207.Crossref 11. Robin AL, Pollack IP, House B, et al: Effects of ALO 2145 on intraocular pressure following argon laser trabeculoplasty . Arch Ophthalmol 1987;105:646-650.Crossref 12. Robin AL, Pollack IP, deFaller JM: Effects of topical ALO 2145 (p-aminoclonidine hydrochloride) on the acute intraocular pressure rise after argon laser iridotomy . Arch Ophthalmol 1987;105:1208-1211.Crossref 13. Shin DH: Bilateral effects of monocular timolol treatment . Am J Ophthalmol 1986;102:275-276.Crossref 14. Smith J, Wandel T: Rationale for the one-eye therapeutic trial . Ann Ophthalmol 1986;18:8. 15. Hernandez Y, Hernandez H, Cervantes R, et al: Cardiovascular effects of topical glaucoma therapies in normal subjects . Cutan Ocular Toxicol 1983;2:99-106.Crossref 16. Allen RC, Langham ME: The intraocular pressure response of conscious rabbits to clonidine . Invest Ophthalmol Vis Sci 1976;15:815-823. 17. Gay AJ, Wolkstein MA: Topical guanethidine therapy for endocrine lid retraction . Arch Ophthalmol 1966;76:364-367.Crossref 18. Ralli R: Clonidine effect on the intraocular pressure and eye circulation . Acta Ophthalmol 1975;125:37. 19. Bill A, Heilmann K: Ocular effects of clonidine in cats and monkeys (Macaca irus) . Exp Eye Res 1975;21:481-488.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Jul 1, 1988

References