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Short Stature and Onychodysplasia: Report of a Case Resembling Senior Syndrome

Short Stature and Onychodysplasia: Report of a Case Resembling Senior Syndrome Abstract A 161/2-year-old white girl with clinical features resembling Senior syndrome (short stature with antenatal onset, onychodysplasia, and digital anomalies) is described. During puberty she manifested a nine-year advancement in osseous maturation over a five-year period without a concomitant increase in growth rate. There has been no evidence of excess androgen or estrogen production, and she has received no exogenous hormones. Whether this phenomenon is a common or sporadic feature of this syndrome is unknown, but caution must be used in counseling these subjects as to eventual height expectation. References 1. Senior B: Impaired growth and onychodysplasia: Short children with tiny toenails . Am J Dis Child 122:7-9, 1971.Crossref 2. Greulich WW, Pyle SI: Radiographic atlas of skeletal development of the hand and wrist , ed 2. Stanford, Calif, Stanford University Press, 1964, pp 154-157. 3. Tanner JM: Growth at adolescence , ed 2. Oxford, England, Blackwell Scientific Publications, 1962, p 55. 4. Smith DW: Recognizable patterns of human malformation . Major Problems Clin Pediatr 7:287, 1970. 5. Wilkins L: The diagnosis and treatment of endocrine disorders in childhood and adolescence , ed 3. Springfield, Ill, Charles C Thomas Publishers, 1965, pp 36-37. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Short Stature and Onychodysplasia: Report of a Case Resembling Senior Syndrome

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Publisher
American Medical Association
Copyright
Copyright © 1973 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1973.04160010078019
Publisher site
See Article on Publisher Site

Abstract

Abstract A 161/2-year-old white girl with clinical features resembling Senior syndrome (short stature with antenatal onset, onychodysplasia, and digital anomalies) is described. During puberty she manifested a nine-year advancement in osseous maturation over a five-year period without a concomitant increase in growth rate. There has been no evidence of excess androgen or estrogen production, and she has received no exogenous hormones. Whether this phenomenon is a common or sporadic feature of this syndrome is unknown, but caution must be used in counseling these subjects as to eventual height expectation. References 1. Senior B: Impaired growth and onychodysplasia: Short children with tiny toenails . Am J Dis Child 122:7-9, 1971.Crossref 2. Greulich WW, Pyle SI: Radiographic atlas of skeletal development of the hand and wrist , ed 2. Stanford, Calif, Stanford University Press, 1964, pp 154-157. 3. Tanner JM: Growth at adolescence , ed 2. Oxford, England, Blackwell Scientific Publications, 1962, p 55. 4. Smith DW: Recognizable patterns of human malformation . Major Problems Clin Pediatr 7:287, 1970. 5. Wilkins L: The diagnosis and treatment of endocrine disorders in childhood and adolescence , ed 3. Springfield, Ill, Charles C Thomas Publishers, 1965, pp 36-37.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Jan 1, 1973

References