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Severe Meningococcal Disease Caused by Serogroups X and Z

Severe Meningococcal Disease Caused by Serogroups X and Z Abstract The minor serogroups of Neisseria meningitidis (X,Y, and Z-W135 and 29 E) were initially considered to be of low virulence and were thought to produce very mild clinical disease. However, since 1974, many reports have appeared in the literature that clearly document that severe meningococcal disease does occur with group Y and group W135.1-7 To our knowledge, there have been no previous reports of severe meningococcal disease in children caused by serogroups X or Z. We report two such cases. One case is that of severe meningococcemia and meningitis with disseminated intravascular coagulation (DIC) caused by group X N meningitidis and one is that of fatal fulminant meningococcemia and meningitis with DIC caused by group Z N meningitidis. Report of Cases.—Case 1.—A 9-month-old infant was well until one day prior to admission, when she experienced fever, vomiting, and a rash. The child was seen at a local References 1. Risko JA, Hodges GR: Neisseria meningitidis serogroup Y: Incidence and description of clinical illness . Am J Med Sci 267:345-352, 1974.Crossref 2. Yee NM, Katz M, Neu HC: Meningitis, pneumonitis and arthritis caused by Neisseria meningitidis group Y . JAMA 232:1354-1355, 1975.Crossref 3. Irwin RS, Woelk WK, Coudin WL: Primary meningococcal pneumonia . Ann Intern Med 82:493-498, 1975.Crossref 4. Koppes GM, Ellenbogen C, Gebhart RJ: Group Y meningococcal disease in United States Air Force recruits . Am J Med 62:661-666, 1977.Crossref 5. Breitenbucher RB, Khan MY: Fatal meningococcemia and meningitis due to meningococcus group Y . Minn Med 60:240-242, 1977. 6. Griffiss JM, Brandt BL: Disease due to serogroup W135 Neisseria meningitidis . Pediatrics 64:218-220, 1979. 7. Hersh JH, Gold R, Lepow ML: Meningococcal group Y pneumonia in an adolescent female . Pediatrics 64:222-224, 1979. 8. Artenstein MS, Winter PE, Gold R: Immunoprophylaxis of meningococcal infection . Milit Med 139:91-95, 1974. 9. Lepow ML, Goldschneider I, Gold R, et al: Persistence of antibody following immunization of children with groups A and C meningococcal polysaccharide vaccines . Pediatrics 60:673-680, 1977. 10. Wahdan MH, Rizk F, El-Akkad AM, et al: A controlled field trial of a serogroup A meningococcal polysaccharide vaccine . Bull WHO 48:667-673, 1973. 11. Peltola H, Mäkelä PH, Elo O, et al: Vaccination against meningococcal group A disease in Finland 1974-75 . Scand J Infect Dis 8:169-174, 1976. 12. Farquhar JD, Hankins WA, Desanctis AN, et al: Clinical and serological evaluation of a meningococcal polysaccharide vaccine groups A, C and Y(39995) . Proc Soc Exp Biol Med 157:79-82, 1978.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Severe Meningococcal Disease Caused by Serogroups X and Z

Severe Meningococcal Disease Caused by Serogroups X and Z

Abstract

Abstract The minor serogroups of Neisseria meningitidis (X,Y, and Z-W135 and 29 E) were initially considered to be of low virulence and were thought to produce very mild clinical disease. However, since 1974, many reports have appeared in the literature that clearly document that severe meningococcal disease does occur with group Y and group W135.1-7 To our knowledge, there have been no previous reports of severe meningococcal disease in children caused by serogroups X or Z. We report two...
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Publisher
American Medical Association
Copyright
Copyright © 1980 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1980.02130240053016
Publisher site
See Article on Publisher Site

Abstract

Abstract The minor serogroups of Neisseria meningitidis (X,Y, and Z-W135 and 29 E) were initially considered to be of low virulence and were thought to produce very mild clinical disease. However, since 1974, many reports have appeared in the literature that clearly document that severe meningococcal disease does occur with group Y and group W135.1-7 To our knowledge, there have been no previous reports of severe meningococcal disease in children caused by serogroups X or Z. We report two such cases. One case is that of severe meningococcemia and meningitis with disseminated intravascular coagulation (DIC) caused by group X N meningitidis and one is that of fatal fulminant meningococcemia and meningitis with DIC caused by group Z N meningitidis. Report of Cases.—Case 1.—A 9-month-old infant was well until one day prior to admission, when she experienced fever, vomiting, and a rash. The child was seen at a local References 1. Risko JA, Hodges GR: Neisseria meningitidis serogroup Y: Incidence and description of clinical illness . Am J Med Sci 267:345-352, 1974.Crossref 2. Yee NM, Katz M, Neu HC: Meningitis, pneumonitis and arthritis caused by Neisseria meningitidis group Y . JAMA 232:1354-1355, 1975.Crossref 3. Irwin RS, Woelk WK, Coudin WL: Primary meningococcal pneumonia . Ann Intern Med 82:493-498, 1975.Crossref 4. Koppes GM, Ellenbogen C, Gebhart RJ: Group Y meningococcal disease in United States Air Force recruits . Am J Med 62:661-666, 1977.Crossref 5. Breitenbucher RB, Khan MY: Fatal meningococcemia and meningitis due to meningococcus group Y . Minn Med 60:240-242, 1977. 6. Griffiss JM, Brandt BL: Disease due to serogroup W135 Neisseria meningitidis . Pediatrics 64:218-220, 1979. 7. Hersh JH, Gold R, Lepow ML: Meningococcal group Y pneumonia in an adolescent female . Pediatrics 64:222-224, 1979. 8. Artenstein MS, Winter PE, Gold R: Immunoprophylaxis of meningococcal infection . Milit Med 139:91-95, 1974. 9. Lepow ML, Goldschneider I, Gold R, et al: Persistence of antibody following immunization of children with groups A and C meningococcal polysaccharide vaccines . Pediatrics 60:673-680, 1977. 10. Wahdan MH, Rizk F, El-Akkad AM, et al: A controlled field trial of a serogroup A meningococcal polysaccharide vaccine . Bull WHO 48:667-673, 1973. 11. Peltola H, Mäkelä PH, Elo O, et al: Vaccination against meningococcal group A disease in Finland 1974-75 . Scand J Infect Dis 8:169-174, 1976. 12. Farquhar JD, Hankins WA, Desanctis AN, et al: Clinical and serological evaluation of a meningococcal polysaccharide vaccine groups A, C and Y(39995) . Proc Soc Exp Biol Med 157:79-82, 1978.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Dec 1, 1980

References