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Severe High-Density Lipoprotein Deficiency Associated With Autoantibodies Against Lecithin:Cholesterol Acyltransferase in Non-Hodgkin Lymphoma

Severe High-Density Lipoprotein Deficiency Associated With Autoantibodies Against... CLINICAL OBSERVATION Severe High-Density Lipoprotein Deficiency Associated With Autoantibodies Against Lecithin:Cholesterol Acyltransferase in Non-Hodgkin Lymphoma Sara Simonelli, PhD; Elisabetta Gianazza, PhD; Giuliana Mombelli, MD; Alighiero Bondioli, MD; Giovanni Ferraro, MD; Silvana Penco, PhD; Cesare R. Sirtori, MD, PhD; Guido Franceschini, PhD; Laura Calabresi, PhD n antibody against the lecithin:cholesterol acyltransferase (LCAT) enzyme, which ne- gates cholesterol esterification in plasma, causing severe high-density lipoprotein de- ficiency (HD), was identified in a woman with a large-cell non-Hodgkin lymphoma. A Successful treatment of the lymphoma resulted in clearance of the antibody and com- plete correction of the defective cholesterol esterification and HD. To our knowledge, an acquired LCAT deficiency leading to severe HD has not been reported previously in association with a ma- lignant disease, and this patient represents the first such documented case. Arch Intern Med. 2012;172(2):179-181 High-density lipoprotein (HDL) defi- ary 2005). (To convert HDL-C to milli- ciency (HD) is a metabolic disorder char- moles per liter, multiply by 0.0259.) Find- acterized by low plasma levels of HDL cho- ings from the physical examination were lesterol (HDL-C). Genetic studies of unremarkable. Results from kidney, liver, Mendelian traits have firmly established the and thyroid function tests were normal. A role of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Internal Medicine American Medical Association

Severe High-Density Lipoprotein Deficiency Associated With Autoantibodies Against Lecithin:Cholesterol Acyltransferase in Non-Hodgkin Lymphoma

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Publisher
American Medical Association
Copyright
Copyright 2012 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6106
eISSN
2168-6114
DOI
10.1001/archinternmed.2011.661
pmid
22271127
Publisher site
See Article on Publisher Site

Abstract

CLINICAL OBSERVATION Severe High-Density Lipoprotein Deficiency Associated With Autoantibodies Against Lecithin:Cholesterol Acyltransferase in Non-Hodgkin Lymphoma Sara Simonelli, PhD; Elisabetta Gianazza, PhD; Giuliana Mombelli, MD; Alighiero Bondioli, MD; Giovanni Ferraro, MD; Silvana Penco, PhD; Cesare R. Sirtori, MD, PhD; Guido Franceschini, PhD; Laura Calabresi, PhD n antibody against the lecithin:cholesterol acyltransferase (LCAT) enzyme, which ne- gates cholesterol esterification in plasma, causing severe high-density lipoprotein de- ficiency (HD), was identified in a woman with a large-cell non-Hodgkin lymphoma. A Successful treatment of the lymphoma resulted in clearance of the antibody and com- plete correction of the defective cholesterol esterification and HD. To our knowledge, an acquired LCAT deficiency leading to severe HD has not been reported previously in association with a ma- lignant disease, and this patient represents the first such documented case. Arch Intern Med. 2012;172(2):179-181 High-density lipoprotein (HDL) defi- ary 2005). (To convert HDL-C to milli- ciency (HD) is a metabolic disorder char- moles per liter, multiply by 0.0259.) Find- acterized by low plasma levels of HDL cho- ings from the physical examination were lesterol (HDL-C). Genetic studies of unremarkable. Results from kidney, liver, Mendelian traits have firmly established the and thyroid function tests were normal. A role of

Journal

JAMA Internal MedicineAmerican Medical Association

Published: Jan 23, 2012

References