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J. Cornfield (1971)
The University Group Diabetes Program. A further statistical analysis of the mortality findings.JAMA, 217 12
H. Keen (1971)
Factors influencing the progress of atherosclerosis in the diabetic.Acta diabetologica latina, 8 Suppl 1
T. Prout, G. Knatterud, C. Meinert, C. Klimt (1972)
The UGDP Controversy: Clinical Trials Versus Clinical ImpressionsDiabetes, 21
J. Wales, A. Grant, F. Wolff (1971)
The effect of tolbutamide on blood pressure.The Journal of pharmacology and experimental therapeutics, 178 1
W. Kannel, M. Hjortland, W. Castelli (1974)
Role of diabetes in congestive heart failure: the Framingham study.The American journal of cardiology, 34 1
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A Summary of Criticisms of the Findings and Conclusions of the University Group Diabetes Program (UGDP)Diabetes, 21
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Mariano Garcia, P. McNamara, T. Gordon, W. Kannell (1974)
Morbidity and Mortality in Diabetics In the Framingham Population: Sixteen Year Follow-up StudyDiabetes, 23
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N. Soler, B. Pentecost, M. Bennett, M. Fitzgerald, P. Lamb, J. Malins (1974)
Coronary care for myocardial infarction in diabetics.Lancet, 1 7856
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Tolbutamide-induced inotropic responses in the perfused working heart: effects of albumin.Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine, 142 3
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A Critique of Methods in Reported Studies of Long-term Vascular Complications in Patients with Diabetes MellitusDiabetes, 22
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Editorials: Statistical problems in clinical trials: the UGDP study revisited.The American journal of medicine, 55 6
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Fatal vascular complications in diabetic patients treated by diet, sulfonylureas and insulin. A retrospective study.Israel journal of medical sciences, 10 7
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Effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. IV. A preliminary report on phenoformin results.JAMA, 217 6
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New drugs and changing mortality from non-infectious disease in England and Wales.British medical bulletin, 26 3
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The University Group Diabetes Program. A statistician looks at the mortality results.JAMA, 217 12
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Long-term tolbutamide treatment after myocardial infarction. A clinical and biochemical study of 178 patients without overt diabetes.Acta medica Scandinavica. Supplementum, 507
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CALLING it the "UGDP controversy" is an understatement. Unquestionably, the study itself triggered lively debate, but it was the prepublication extracting of supportive statements from the American Diabetes Association,1 the American Medical Association,2 the Food and Drug Administration (FDA),3 and the press (New York Times, May 21, 1970; Wall Street Journal, May 21, 1970; Washington Post, May 22, 1970) that broadened the issue far beyond the implications of the University Group Diabetes Program (UGDP) itself. History now repeats itself, in that furor has again been created by reckless extrapolation of a small and temporary cardiovascular mortality trend observed in the UGDP to the entire diabetic population of the United States,4 and by unilateral publicizing (AMA news release, Jan 27, 1975) of the controversy. The observations and comments that follow relate not only to the espoused biostatistical validity5 of the original UGDP report,6 but also
JAMA – American Medical Association
Published: May 26, 1975
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