The purpose of this study was to test the hypothesis that personal characteristics of drive, achievement, and leadership are positively associated with the level of uric acid in the serum. Among seven behavior scales which were developed, drive, achievement, and leadership correlated most highly with serum urate levels. The correlation coefficient between the total of all behavior scales and serum urate in 51 University of Michigan professors was r = 0.66, a very high order of relationship for such studies between behavior variables and physiological ones. The results of this study lend substantial support to the hypotheses that a tendency to gout is a tendency to the executive suite, and that serum uric acid is related to behavioral characteristics that lead to outstanding performance. There is now a need for pharmacological experiments to see if the concept of serum urate as an endogenous cortical stimulant can also be supported.
JAMA – American Medical Association
Published: Feb 7, 1966